ChemicalBook >> CAS DataBase List >>4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid structure

CAS No.: 78851-85-1

Chemical Name:: 4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid

Synonyms: 4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid;4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl);2-succinylamido-1,3,4-thiadiazole-5-sulfonamide;4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid;Butanoic acid, 4-[[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-

CBNumber:: CB6241771

Molecular Formula:: C6H8N4O5S2

Molecular Weight:: 280.28

MDL Number:: MFCD01104616

MOL File:: 78851-85-1.mol

Last updated:2026-09-12 18:54:07

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4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid Properties

Density	1.807±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	4.17±0.10(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	293457	4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid	78851-85-1	50.00mg	$134	2026-05-19	Buy
Matrix Scientific	293457	4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid	78851-85-1	100.00mg	$190	2026-05-19	Buy
Matrix Scientific	293457	4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid	78851-85-1	250.00mg	$290	2026-05-19	Buy
Ambeed	A110298	4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid 97%	78851-85-1	50mg	$111	2026-06-05	Buy
Ambeed	A110298	4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid 97%	78851-85-1	100mg	$154	2026-06-05	Buy

Product number	Packaging	Price	Buy
293457	50.00mg	$134	Buy
293457	100.00mg	$190	Buy
293457	250.00mg	$290	Buy
A110298	50mg	$111	Buy
A110298	100mg	$154	Buy

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid Chemical Properties, Uses, Production

Synthesis

108-30-5

14949-00-9

78851-85-1

General procedure for the synthesis of 4-[[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxobutanoic acid from succinic anhydride and 5-amino-1,3,4-thiadiazole-2-sulfonamide: To a solution of 5-amino-1,3,4-thiadiazole-2-sulfonamide (0.40 g, 2.22 mmol) in N,N-dimethylformamide was added Succinic anhydride (0.22 g, 2.22 mmol). The reaction mixture was heated at 100 °C with stirring for 12 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator to afford the crude product 4-[[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxobutanoic acid (0.60 g, 96% yield), which can be used in the next step of the reaction without further purification. The structure of the product was confirmed by the following characterization data: 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 2H), 2.78 (t, J = 6.6 Hz, 2H), 2.62 (t, J = 6.4 Hz, 2H); 13C NMR (100 MHz, DMSO-d6) δ 174.08, 172.38, 164.52 , 162.15, 30.77, 29.08; HRMS (ESI+): m/z Calculated value C6H9N4O5S2 [M + H]+: 281.0014, measured value: 281.0009.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 5, p. 915 - 921
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 5077 - 5088
[3] Patent: WO2017/161144, 2017, A1. Location in patent: Page/Page column 69
[4] Patent: US2005/143366, 2005, A1. Location in patent: Page/Page column 18
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4851 - 4856

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid synthesis

Synthesis of 4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid from Succinic anhydride and 5-Amino-1,3,4-thiadiazole-2-sulfonamide

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid Preparation Products And Raw materials

Raw materials

5-Amino-1,3,4-thiadiazole-2-sulfonamide Succinic anhydride

Preparation Products

4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid Suppliers

Global Suppliers ( 22)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58
Taizhou Nanfeng Pharmaceutical Research Institute	nanfengpharma@126.co 18616377689	nanfengpharma@126.com	China	20008	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44871	58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，	028-83243028 19136088901	sinostandards@163.com	China	4979	58
Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	39796	58
Bide Pharmatech Ltd.	400-6005915	sales@picasso-e.com	China	39645	58
Zhengzhou Converging Chemical Co. LTD	0371-53399770 18037166334	3857571523@qq.com	China	7212	58
Xuchang Fengfei New Materials Technology Co., Ltd	19713077352; 19713077352	1038096457@qq.com	China	2333	58

Supplier	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58
Aikon International Limited	58
Taizhou Nanfeng Pharmaceutical Research Institute	58
Energy Chemical	58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，	58
Shanghai Haohong Pharmaceutical Co., Ltd.	58
Bide Pharmatech Ltd.	58
Zhengzhou Converging Chemical Co. LTD	58
Xuchang Fengfei New Materials Technology Co., Ltd	58

78851-85-1 (4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid) Related Search:

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2-succinylamido-1,3,4-thiadiazole-5-sulfonamide 4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl) Butanoic acid, 4-[[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo- 4-Oxo-4-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)amino)butanoic acid 4-[[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]amino]-4-oxo-butanoic acid 78851-85-1 C6H8N4O5S2