1H-Indazole, 5-bromo-7-iodo-
- CAS No.
- 953410-86-1
- Chemical Name:
- 1H-Indazole, 5-bromo-7-iodo-
- Synonyms
- 5-Bromo-7-iodo-1H-indazole;1H-Indazole, 5-bromo-7-iodo-;1-cyclopropyl-4,6-difluoro-5-iodo-1,3-benzodiazole
- CBNumber:
- CB62502733
- Molecular Formula:
- C7H4BrIN2
- Molecular Weight:
- 322.93
- MDL Number:
- MFCD13177018
- MOL File:
- 953410-86-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-7-iodo-1H-indazole | FB143800 | 250mg | $250 |
| 5-Bromo-7-iodo-1H-indazole | Y5682 | 1g | $320 |
| 5-Bromo-7-iodo-1H-indazole | FB143800 | 500mg | $350 |
| 5-Bromo-7-iodo-1H-indazole | FB143800 | 1g | $500 |
| 5-BROMO-7-IODO-1H-INDAZOLE 95.00% | HCH0367065 | 1G | $805.35 |
| Boiling point | 410.4±30.0 °C(Predicted) |
|---|---|
| Density | 2.421±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 10.78±0.40(Predicted) |
| Appearance | Light brown to khaki Solid |
| InChI | InChI=1S/C7H4BrIN2/c8-5-1-4-3-10-11-7(4)6(9)2-5/h1-3H,(H,10,11) |
| InChIKey | GEPPVMLPAUPZTA-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Br)C=C2I)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
1H-Indazole, 5-bromo-7-iodo- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB143800 | 5-Bromo-7-iodo-1H-indazole | 953410-86-1 | 250mg | $250 | 2021-12-16 | Buy |
| AK Scientific | Y5682 | 5-Bromo-7-iodo-1H-indazole | 953410-86-1 | 1g | $320 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB143800 | 5-Bromo-7-iodo-1H-indazole | 953410-86-1 | 500mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB143800 | 5-Bromo-7-iodo-1H-indazole | 953410-86-1 | 1g | $500 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0367065 | 5-BROMO-7-IODO-1H-INDAZOLE 95.00% | 953410-86-1 | 1G | $805.35 | 2021-12-16 | Buy |
1H-Indazole, 5-bromo-7-iodo- Chemical Properties,Uses,Production
Synthesis
922170-67-0
953410-86-1
Acetic anhydride (6.209 g, 60.87 mmol) was added slowly and dropwise to a solution of 4-bromo-2-iodo-6-methylaniline (6.31 g, 20.29 mmol) and potassium acetate (2.386 g, 24.35 mmol) in chloroform (100 mL) at 0 °C and under nitrogen protection. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction system was warmed to 60 °C, tert-butyl nitrite (10.3 g, 0.1 mol) was added and stirred at 60 °C overnight. Upon completion of the reaction, the mixture was diluted with water and extracted with dichloromethane (2 x 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was dissolved in a mixture of methanol and 6N hydrochloric acid (1:1, v/v) and stirred at room temperature for 5 hours. The reaction solution was adjusted to alkaline with 10N aqueous sodium hydroxide and extracted again with dichloromethane (2 x 100 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (100:10:1) as eluent to afford 5-bromo-7-iodo-1hydro-indazole (3.73 g, 57.1% yield) as a light yellow solid. lc/ivis (ESI) m/z: 323 (M+H)+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 334 - 337
[2] Patent: WO2018/160889, 2018, A1. Location in patent: Page/Page column 638; 639; 640
1H-Indazole, 5-bromo-7-iodo- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indazole, 5-bromo-7-iodo- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Devinchem Ltd | 027-65318838 13646286950 | sales@devinchem.com | China | 2975 | 58 |
| Hebei Weite Medical Technology Co., Ltd | 13180081292 13180081292 | contact@wetogethermed.com | China | 7819 | 58 |
View Lastest Price from 1H-Indazole, 5-bromo-7-iodo- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1H-Indazole, 5-bromo-7-iodo-
953410-86-1
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 1H-Indazole, 5-bromo-7-iodo-
953410-86-1
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
