3-(cyanomethyl)picolinonitrile
- CAS No.
- 5912-34-5
- Chemical Name:
- 3-(cyanomethyl)picolinonitrile
- Synonyms
- 3-(Cyanomethyl);3-(cyanomethyl)picolinonitrile;3-Pyridineacetonitrile, 2-cyano-
- CBNumber:
- CB62520366
- Molecular Formula:
- C8H5N3
- Molecular Weight:
- 143.15
- MDL Number:
- MFCD07186240
- MOL File:
- 5912-34-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P271 |
| HS Code | 2933399990 |
3-(cyanomethyl)picolinonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS114491 | 3-(Cyanomethyl)picolinonitrile 97% | 5912-34-5 | 250mg | $170 | 2026-06-04 | Buy |
| Activate Scientific | AS114491 | 3-(Cyanomethyl)picolinonitrile 97% | 5912-34-5 | 1g | $373 | 2026-06-04 | Buy |
| Activate Scientific | AS114491 | 3-(Cyanomethyl)picolinonitrile 97% | 5912-34-5 | 5g | $1469 | 2026-06-04 | Buy |
| Matrix Scientific | 306969 | 3-(Cyanomethyl)picolinonitrile | 5912-34-5 | 250.00mg | $86 | 2026-05-19 | Buy |
| Matrix Scientific | 306969 | 3-(Cyanomethyl)picolinonitrile | 5912-34-5 | 1.00g | $278 | 2026-05-19 | Buy |
3-(cyanomethyl)picolinonitrile Chemical Properties, Uses, Production
Synthesis
6635-88-7
7677-24-9
5912-34-5
Under nitrogen protection, (1-yloxy-pyridin-3-yl)-acetonitrile (10 g, 75 mmol) was suspended in anhydrous dichloromethane and trimethylcyanosilane (10.95 mL, 82 mmol) and dimethylcarbamoyl chloride (7.55 mL, 82 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 72 hours and then concentrated. To the concentrated residue was added ethyl acetate (100 mL), the organic phase was washed with 1 M sodium hydroxide solution (150 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The resulting solid was purified by column chromatography (50% ethyl acetate/hexane) to give 7.08 g (66% yield) of 3-(cyanomethyl)-2-cyanopyridine as a yellow solid with a melting point of 48-51 °C; mass spectrum (+) APCI m/z 144 [M + H]+. Reference: WO 9818796.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 9, p. 3331 - 3347
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 4, p. 675 - 682
[3] Patent: EP1147083, 2004, B1. Location in patent: Page 49
[4] Organic Process Research and Development, 2010, vol. 14, # 4, p. 883 - 889
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7472 - 7479
3-(cyanomethyl)picolinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-(cyanomethyl)picolinonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
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| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
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| Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. | 027-50664929, 13971561712 | hubxys2001@163.com | China | 1436 | 55 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7994 | 58 |
