4-Methyl Erlotinib Hydrochloride
- CAS No.
- 1346601-52-2
- Chemical Name:
- 4-Methyl Erlotinib Hydrochloride
- Synonyms
- OSI-597;Erlotinib-9;4-methyl Erlotinib;Erlotinib iMpurity G;Erlotinib impurities406;Erlotinib 4-Methyl Analog;4-Methyl Erlotinib Hydrochloride;Azilsartan medoxomil impurity248;Erlotinib Hydrochloride iMpurity 8;N-(3-Ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
- CBNumber:
- CB62544810
- Molecular Formula:
- C23H25N3O4
- Molecular Weight:
- 407.46
- MDL Number:
- MFCD32201999
- MOL File:
- 1346601-52-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-methyl Erlotinib ≥95% | 9001510 | 1mg | $90 |
| 4-methyl Erlotinib ≥95% | 9001510 | 5mg | $392 |
| 4-methyl Erlotinib ≥95% | 9001510 | 10mg | $696 |
| 4-Methyl Erlotinib Hydrochloride | TRC-M304630-5MG | 5mg | $166 |
| 4-Methyl Erlotinib Hydrochloride | TRC-M304630-50MG | 50mg | $1494 |
| Melting point | 224-228°C (dec.) |
|---|---|
| Boiling point | 567.5±50.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO, Methanol (Slightly) |
| pka | 5.33±0.30(Predicted) |
| form | Solid |
| color | Pale Pink to Pale Brown |
4-Methyl Erlotinib Hydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9001510 | 4-methyl Erlotinib ≥95% | 1346601-52-2 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 9001510 | 4-methyl Erlotinib ≥95% | 1346601-52-2 | 5mg | $392 | 2026-04-30 | Buy |
| Cayman Chemical | 9001510 | 4-methyl Erlotinib ≥95% | 1346601-52-2 | 10mg | $696 | 2026-04-30 | Buy |
| TRC | TRC-M304630-5MG | 4-Methyl Erlotinib Hydrochloride | 5mg | $166 | 2026-06-03 | Buy | |
| TRC | TRC-M304630-50MG | 4-Methyl Erlotinib Hydrochloride | 50mg | $1494 | 2026-06-03 | Buy |
4-Methyl Erlotinib Hydrochloride Chemical Properties,Uses,Production
Uses
Erlotinib (E625000) derivative as internal standard for HPLC.
Biological Activity
4-methyl erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (egfr) [1].the epidermal growth factor receptor (egfr) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].erlotinib inhibits egfr-associated kinase activity by binding to the egf-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].
References
[1] stamos, j. ,sliwkowski, m.x. and eigenbrot, c. structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. the journal of biological chemisty 277(48), 46265-46272 (2002).
[2] ciardiello f, tortora g. a novel approach in the treatment of cancer: targeting the epidermal growth factor receptor[j]. clinical cancer research, 2001, 7(10): 2958-2970.
[3] shepherd f a, rodrigues pereira j, ciuleanu t, et al. erlotinib in previously treated non–small-cell lung cancer[j]. new england journal of medicine, 2005, 353(2): 123-132.
4-Methyl Erlotinib Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methyl Erlotinib Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14320 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3147 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
| Shanghai Payne Pharmaceutical Technology Co.Ltd | 021-58123769 18678586262 | info@paynepharm.com | China | 1352 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Chengdu Miracle Pharmaceutical Co., Ltd. | 028-86136736 19130631884 | sales@mic-pharma.com | China | 346 | 56 |
| XinYao(Shenzhen) Biological Technology Co., Ltd. | 0755-89880280 | 3004662104@qq.com | China | 1826 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
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