3-Ethynylaniline
- CAS No.
- 54060-30-9
- Chemical Name:
- 3-Ethynylaniline
- Synonyms
- 3-ETHYNYLANILINE;3-ETHYNYL-PHENYLAMINE;3-EthynylbenzaMine;M-AMINOPHENYL ACETYLENE;SOLI-006;3-Ethynyl;Erlotinib-8;Erlotinib INT;3-Ethynlaniline;m-Ethnylaniline
- CBNumber:
- CB4417819
- Molecular Formula:
- C8H7N
- Molecular Weight:
- 117.15
- MDL Number:
- MFCD00014779
- MOL File:
- 54060-30-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Ethynylaniline ≥98% | 498289 | 5g | $99.75 |
| 3-Ethynylaniline >98.0%(GC) | A1122 | 10g | $105 |
| 3-Ethynylaniline >98.0%(GC) | A1122 | 25g | $193 |
| 3-Ethynylaniline >98.0%(GC) | A1122 | 5g | $65 |
| 3-Ethynylaniline | E685070 | 10mg | $55 |
| More product size | |||
| Melting point | 27°C |
|---|---|
| Boiling point | 92-93 °C (2 mmHg) |
| Density | 1.04 |
| refractive index | 1.614-1.616 |
| Flash point | 138 °F |
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly) |
| pka | 3.67±0.10(Predicted) |
| form | Liquid |
| Specific Gravity | 1.12 |
| color | Clear yellow to brown |
| Water Solubility | Insoluble in water. |
| BRN | 2935417 |
| Stability | Light Sensitive |
| InChIKey | NNKQLUVBPJEUOR-UHFFFAOYSA-N |
| CAS DataBase Reference | 54060-30-9(CAS DataBase Reference) |
| FDA UNII | DU8GFZ5KGE |
| NIST Chemistry Reference | M-aminophenylacetylene(54060-30-9) |
| EPA Substance Registry System | Benzenamine, 3-ethynyl- (54060-30-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39-36/37 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29214990 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Ethynylaniline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 498289 | 3-Ethynylaniline ≥98% | 54060-30-9 | 5g | $99.75 | 2025-07-31 | Buy |
| TCI Chemical | A1122 | 3-Ethynylaniline >98.0%(GC) | 54060-30-9 | 10g | $105 | 2021-12-16 | Buy |
| TCI Chemical | A1122 | 3-Ethynylaniline >98.0%(GC) | 54060-30-9 | 25g | $193 | 2025-07-31 | Buy |
| TCI Chemical | A1122 | 3-Ethynylaniline >98.0%(GC) | 54060-30-9 | 5g | $65 | 2025-07-31 | Buy |
| TRC | E685070 | 3-Ethynylaniline | 54060-30-9 | 10mg | $55 | 2021-12-16 | Buy |
3-Ethynylaniline Chemical Properties,Uses,Production
Chemical Properties
Clear yellowish to brown liquid
Uses
Reagent in the preparation of a labelled metabolite of Erlotinib (E625000).
Uses
3-Aminophenylacetylene is used as a pharmaceutical intermediate.
Application
3-Ethynylaniline may be used in the synthesis of the following benzoxazine monomers: bis{4-[3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazin-6-yloxy)]phenyl}phenylphosphino-1-one, [3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazaperhydroin-6-yl)][3-(3-ethynylphenyl)(2H,4H-benzo[3,4-e]1,3-oxazin-6-yl)]phenylphosphino-1-one, and bis[3-(3-ethynylphenyl)(2H,4Hbenzo[3,4-e]1,3-oxazin-6-yl)oxy]phenylphosphino-1-one.
It may be used:
To synthesize succin(m-ethynyl)dianilide and sebaco(m-ethynyl)dianilide. As a reagent in the multi-step synthesis of erlotinib hydrochloride. To prepare 3-(3-ethynylphenyl)-6-methyl-2H, 4H-benzo[e]1,3-oxazine. To prepare 3-[3-(4-acetylamino-benzyl)-[1,2,4]oxadiazol-5- yl]-N-(3-ethynyl-phenyl)-propionamide.
General Description
3-Ethynylaniline is a terminal alkyne that can be prepared by the reduction of 3-ethylnylnitrobenzene.
reaction suitability
reaction type: click chemistry
Synthesis
Starting with m-nitrocinnamic acid: First, it undergoes an addition reaction with liquid bromine in glacial acetic acid to generate 3-(3-nitro)phenyl-2,3-dibromopropionic acid; subsequently, it undergoes dehydrobromination and decarboxylation reactions under the action of an organic base (such as DBU) to generate the key intermediate m-nitrophenylacetylene; finally, the nitro group is reduced to an amino group using iron powder in an acidic aqueous ethanol solution to obtain the target product 3-Ethynylaniline.
3-Ethynylaniline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| Wuhan Mayue Longteng Technology Development Co., Ltd. | +undefined15171477138 | helen.yan@lantu-tech.com | China | 293 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8554 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8757 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5244 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20130 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21603 | 55 |
View Lastest Price from 3-Ethynylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-01-07 | 3-Aminophenylacetylene
54060-30-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-01-07 | 3-Aminophenylacetylene
54060-30-9
|
US $14.00-264.00 / g | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-01-05 | 3-Aminophenylacetylene
54060-30-9
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Aminophenylacetylene
54060-30-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 3-Aminophenylacetylene
54060-30-9
- US $14.00-264.00 / g
- 0.98
- Shanghai UCHEM Inc.
-
- 3-Aminophenylacetylene
54060-30-9
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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