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Azelastine

Azelastine structure

CAS No.: 58581-89-8

Chemical Name:: Azelastine

Synonyms: -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP

CBNumber:: CB6256007

Molecular Formula:: C22H24ClN3O

Molecular Weight:: 381.9

MDL Number:: MFCD00242781

MOL File:: 58581-89-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-10 08:17:50

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Azelastine Properties

Melting point	111 - 115°C
Boiling point	533.9±60.0 °C(Predicted)
Density	1.1505 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka	pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form	Solid
color	White to Off-White
BCS Class	1
Stability	Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI	InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
InChIKey	MBUVEWMHONZEQD-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(Cl)C=C2)=NN1C1CCCN(C)CC1
CAS DataBase Reference	58581-89-8(CAS DataBase Reference)
FDA UNII	ZQI909440X
ATC code	R01AC03,R06AX19,S01GX07

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H312-H302-H335-H332
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501
Hazardous Substances Data	58581-89-8(Hazardous Substances Data)
Toxicity	LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81

Azelastine price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-A767410-500MG	Azelastine	58581-89-8	500mg	$339	2026-06-03	Buy
TRC	TRC-A767410-100MG	Azelastine	58581-89-8	100mg	$144	2026-06-03	Buy
ChemScene	CS-2883	Azelastine 99.92%	58581-89-8	5mg	$32	2026-06-04	Buy
ChemScene	CS-2883	Azelastine 99.92%	58581-89-8	10mg	$52	2026-06-04	Buy
ChemScene	CS-2883	Azelastine 99.92%	58581-89-8	25mg	$104	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-A767410-500MG	500mg	$339	Buy
TRC-A767410-100MG	100mg	$144	Buy
CS-2883	5mg	$32	Buy
CS-2883	10mg	$52	Buy
CS-2883	25mg	$104	Buy

Azelastine Chemical Properties, Uses, Production

Description

Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

brand name

Astelin (Medpointe); Optivar (Medpointe).

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl^- .

Azelastine Preparation Products And Raw materials

Raw materials

3-Methoxypropionic acid 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane

Acetophenone

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Preparation Products

Azelastine Suppliers

Global Suppliers ( 173)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Fortuna Chemical Co., Ltd	027-59207852 13308628970	buy@fortunachem.com	China	2579	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
China Langchem Inc.	0086-21-58956006		China	7798	57
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4484	50
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
Shanghai CanSpecsci Instrument Co., Ltd.	400-6087598 15021221957	order@canspecsci.com	China	2001	56
HangZhou YuHao Chemical Technology Co., Ltd.	0571-82693216	info@yuhaochemical.com	China	1999	58
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55

Supplier	Advantage
Wuhan Fortuna Chemical Co., Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
LGM Pharma	70
China Langchem Inc.	57
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
MedChemexpress LLC	58
Nanjing Sunlida Biological Technology Co., Ltd.	55
Shanghai CanSpecsci Instrument Co., Ltd.	56
HangZhou YuHao Chemical Technology Co., Ltd.	58
Shanghai YuLue Chemical Co., Ltd.	55

View Latest Price from Azelastine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	Azelastine 58581-89-8		10g	98%min	120kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-10	Azelastine 58581-89-8	$50.00		99.99%	10g	TargetMol Chemicals Inc.
2026-07-27	Azelastine 58581-89-8	$50.00		99.99%	10g	TargetMol Chemicals Inc.

Azelastine
58581-89-8
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Azelastine
58581-89-8
$50.00
99.99%
TargetMol Chemicals Inc.

Azelastine
58581-89-8
$50.00
99.99%
TargetMol Chemicals Inc.

Azelastine Spectrum

Azelastine(58581-89-8)¹HNMR

58581-89-8 (Azelastine) Related Search:

Methyl acetate Methyl acrylate 2-Methylnaphthalene Bensulfuron methyl Methylparaben

Chlorodimethylphenylsilane DBU Kresoxim-methyl 1-AdaMantanethylaMine Triphenylphosphine

Thiophanate-methyl Dimethylnaphthalene, mixture of isomers Methyl thiophene-2-carboxylate Methyl Phenylacetone

Sibutramine hydrochloride Parathion-methyl Tramadol hydrochloride

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1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one Azelastinum [INN-Latin] KBio3_002992 SPBio_000657 Spectrum2_000649 Spectrum3_001984 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone -4-yl)- AZELASTINE 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one CAS 790307-93-0 Azeptin：Rhino1ast 2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Azelastine & Azelastine Hydrochloride Azelastine base 4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2 Azelastine USP/EP/BP Phenylpyruvic Acid Impurity 7 Azelastine, 10 mM in DMSO Azelastine (Standard) 58581-89-8 53408-27-6 C22H26ClN3O TELAZOL API