Sodium D-pantothenate
- CAS No.
- 867-81-2
- Chemical Name:
- Sodium D-pantothenate
- Synonyms
- SODIUM PANTOTHENATE;D-Pantothenic;D-Pantothenate Sodium;D-PANTOTHENIC ACID SODIUM SALT;heta)-;Sodium D;SodiuM D-Pan;vitamin B5 sodium;PANTOTHENATESODIUM;SODIUM PANTHOTENATE
- CBNumber:
- CB6256810
- Molecular Formula:
- C9H16NNaO5
- Molecular Weight:
- 241.22
- MDL Number:
- MFCD00002767
- MOL File:
- 867-81-2.mol
| Product description | Number | Pack Size | Price |
| Sodium D-Pantothenate >97.0%(N) | P0013 | 25g | $67 |
| Sodium D-Pantothenate >97.0%(N) | P0013 | 250g | $624 |
| D-Pantothenic Acid (sodium salt) ≥98% | 17288 | 25g | $71 |
| D-Pantothenic Acid (sodium salt) ≥98% | 17288 | 50g | $133 |
| D-Pantothenic Acid (sodium salt) ≥98% | 17288 | 100g | $254 |
| More product size | |||
| Melting point | 171-178 °C(lit.) |
|---|---|
| alpha | D25 +27.1° (c = 2) |
| refractive index | 27 ° (C=5, H2O) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| optical activity | 24.2°(C=0.01g/mI, H2O, 20°C, 589nm) |
| Stability | Hygroscopic |
| InChI | InChI=1/C9H17NO5.Na/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;+1/p-1/t7-;/s3 |
| InChIKey | GQTHJBOWLPZUOI-WMASNCOMNA-M |
| SMILES | [C@H](O)(C(=O)NCCC([O-])=O)C(C)(C)CO.[Na+] |&1:0,r| |
| LogP | -0.849 (est) |
| CAS DataBase Reference | 867-81-2(CAS DataBase Reference) |
| FDA 21 CFR | 582.5772 |
| Substances Added to Food (formerly EAFUS) | SODIUM PANTOTHENATE |
| SCOGS (Select Committee on GRAS Substances) | D- or DL- Sodium pantothenate |
| EWG's Food Scores | 1 |
| FDA UNII | OES0R93F0C |
| EPA Substance Registry System | .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, monosodium salt (867-81-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-48-41-37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22-24/25 | |||||||||
| HS Code | 29241990 | |||||||||
| Hazardous Substances Data | 867-81-2(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Sodium D-pantothenate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P0013 | Sodium D-Pantothenate >97.0%(N) | 867-81-2 | 25g | $67 | 2025-07-31 | Buy |
| TCI Chemical | P0013 | Sodium D-Pantothenate >97.0%(N) | 867-81-2 | 250g | $624 | 2025-07-31 | Buy |
| Cayman Chemical | 17288 | D-Pantothenic Acid (sodium salt) ≥98% | 867-81-2 | 25g | $71 | 2024-03-01 | Buy |
| Cayman Chemical | 17288 | D-Pantothenic Acid (sodium salt) ≥98% | 867-81-2 | 50g | $133 | 2024-03-01 | Buy |
| Cayman Chemical | 17288 | D-Pantothenic Acid (sodium salt) ≥98% | 867-81-2 | 100g | $254 | 2024-03-01 | Buy |
Sodium D-pantothenate Chemical Properties,Uses,Production
Description
Sodium D-pantothenate is the sodium salt of the biological active enantiomer of pantothenic acid (vitamin B5). As D-pantothenic acid is a precursor in the biosynthesis of coenzyme A, sodium D- pantothenate is used in the synthesis of coenzyme A. It is also used in foods as a dietary supplement.
References
[1] George A. Burdock, Encyclopedia of Food and Color Additives, volume 3, 1996
Chemical Properties
White crystal or powder
Uses
D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].
Synthesis
16690-93-0
599-04-2
867-81-2
The general procedure for the synthesis of sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate from sodium 3-aminopropionate and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone was as follows: 55.5 g of sodium 3-aminopropionate and 65 g of dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were dissolved in 350 ml of anhydrous ethanol and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was filtered while hot and the reaction vessel was washed with 50 ml of ethanol. The washed solution was combined with the filtrate and the combined filtrate was allowed to stand at 0 °C for 5 days. Subsequently, it was filtered and the resulting solid was washed with a small amount of ethanol. Finally, the solid was dried to constant weight under reduced pressure at room temperature to obtain 76.3 g of white crystalline powder, namely sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate (sodium D-pantothenate), whose crystal structure is as described in GB565976.
in vivo
Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2].
| Animal Model: | Female ICR mice weighing 29-35 g[2] |
| Dosage: | 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered) |
| Administration: | Injected intraperitoneally (i.p.) on day 8.5 of gestation |
| Result: | Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced. |
IC 50
Human Endogenous Metabolite
Purification Methods
Crystallise the salt from absolute EtOH. It is very hygroscopic (keep in sealed ampoules). The free acid is a viscous hygroscopic oil with [] 25D +37.5o (c 5, H2O), easily destroyed by acids and bases. [Beilstein 4 IV 2569.]
References
[1] Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. DOI:10.1007/s11356-017-0774-8
[2] M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. DOI:10.1002/tera.1420520306
Sodium D-pantothenate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from Sodium D-pantothenate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-16 | Sodium D-pantothenate
867-81-2
|
US $0.00-0.00 / Kg/Drum | 1KG | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-10-15 | D-Pantothenic acid sodium
867-81-2
|
US $35.00-43.00 / mg | 99.50% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-08-08 | Sodium D-pantothenate
867-81-2
|
US $100.00 / KG | 1KG | 99% | 20T | Sichuan Zhuoyu Yantang Technology Co., Ltd. |
-
- Sodium D-pantothenate
867-81-2
- US $0.00-0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- D-Pantothenic acid sodium
867-81-2
- US $35.00-43.00 / mg
- 99.50%
- TargetMol Chemicals Inc.
-
- Sodium D-pantothenate
867-81-2
- US $100.00 / KG
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
