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CAY10574

CAY10574 Structure
CAY10574 structure
CAS No.
140651-18-9
Chemical Name:
CAY10574
Synonyms
CAN-508;CAY10574;CAN508 ，E2373;Cdk9 Inhibitor II;CAN-508 (CAN508);CAN508, 10 mM in DMSO;CaMKII Inhibitor, CK59;CAY10574, Cdk9 kinase inhibitor;4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol;4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol
CBNumber:
CB62590428
Molecular Formula:
C9H10N6O
Molecular Weight:
218.22
MDL Number:
MFCD09262258
MOL File:
140651-18-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

CAY10574 Properties

Boiling point 638.3±55.0 °C(Predicted)
Density 1.67±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMF: 0.5 mg/ml; DMSO: 0.5 mg/ml
pka 8.52±0.30(Predicted)
form Yellow semi-solid
color Light yellow to yellow
InChI 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
InChIKey AYZRKFOEZQBUEA-UHFFFAOYSA-N
SMILES [nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N
FDA UNII ZG0O47K626
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 2
Storage Class 11 - Combustible Solids

CAY10574 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem 140651-18-9 5mg $318 2026-04-30 Buy
Cayman Chemical 10011247 CAY10574 ≥95% 140651-18-9 1mg $28 2026-04-30 Buy
Cayman Chemical 10011247 CAY10574 ≥95% 140651-18-9 5mg $118 2026-04-30 Buy
Cayman Chemical 10011247 CAY10574 ≥95% 140651-18-9 10mg $205 2026-04-30 Buy
Cayman Chemical 10011247 CAY10574 ≥95% 140651-18-9 50mg $888 2026-04-30 Buy
Product number Packaging Price Buy
238811 5mg $318 Buy
10011247 1mg $28 Buy
10011247 5mg $118 Buy
10011247 10mg $205 Buy
10011247 50mg $888 Buy

CAY10574 Chemical Properties, Uses, Production

Uses

Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes.

Definition

ChEBI: CAN-508 is a member of the class of pyrazoles that is 1H-pyrazole substituted by amino, (4-hydroxyphenyl)diazenyl, and amino groups at positions 3, 4 and 5, respectively. It is a CDK9 inhibitor (IC50 = 0.35 muM) with 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. It has a role as an angiogenesis inhibitor, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrazoles, a member of phenols, an aromatic amine and a monoazo compound.

General Description

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 μM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 μM) and GLUT4 membrane translocation (IC50 = 100 μM) in 3T3-L1 adipocytes.

Biological Activity

Cell permeable: yes', 'Primary Target
Cdk9', 'Product competes with ATP.', 'Reversible: no', 'Target IC50: 350 nM, using Cdk9/T1

in vivo

CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts[1].

Animal Model:4 weeks-old female nude mice (esophageal adenocarcinoma xenografts)[1]
Dosage:60 mg/kg
Administration:I.p.; daily for 10 days
Result:Caused reduction of tumor growth starting from post-treatment day three with 50.83% reduction.

IC 50

CDK9/cyclinT1: 0.35 μM (IC50); CDK2/cyclinE: 20 μM (IC50); cdk2/cyclin A: 69 μM (IC50); Cdk4/cyclin D1: 13.5 μM (IC50); CDK7/cyclin H: 26 μM (IC50); Cdk1/cyclin B: 44 μM (IC50)

CAY10574 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10574 Suppliers

Global Suppliers ( 71)
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9778 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
Sigma-Aldrich 80
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Latest Price from CAY10574 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CAN508 pictures 2026-08-08 CAN508
140651-18-9
 $53.00-119.00 98.65% 10g TargetMol Chemicals Inc.
  • CAN508 pictures
  • CAN508
    140651-18-9
  • $53.00-119.00
  • 98.65%
  • TargetMol Chemicals Inc.

CAY10574 Spectrum

CAY10574(140651-18-9)1HNMR

140651-18-9 (CAY10574) Related Search:

NU6102 BMS-265246 [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) Purvalanol a YKL-5-124
CDK12-CCNK HETERODIMER Protein, HUMAN (SF9)

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CAY10574 Cdk9 Inhibitor II 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol CAN-508 (CAN508) CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem inhibit,CAN 508,ATP-competitive,Cyclin dependent kinase,esophageal,cells,CDK,CAN508,Inhibitor,adenocarcinoma,HT-29,CAN-508 Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]- 4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol CAY10574, Cdk9 kinase inhibitor CAN508, 10 mM in DMSO CaMKII Inhibitor, CK59 CAN508 ，E2373 CAN-508 140651-18-9