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Purvalanol a

Purvalanol a structure

CAS No.: 212844-53-6

Chemical Name:: Purvalanol a

Synonyms: NG-60;PurvaL;CH61386;CS-1631;CDKinhibitor;Purvalanol a;(R)-Purvalanol A;NG 60;NG60;NG-60;PURVALANOLA, >98%;Purvalanol A(NG 60)

CBNumber:: CB5283664

Molecular Formula:: C19H25ClN6O

Molecular Weight:: 388.89

MDL Number:: MFCD02179211

MOL File:: 212844-53-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:27

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Purvalanol a Properties

Boiling point	590.5±60.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	methylene chloride: 50 mg/mL, clear, colorless
form	powder
pka	14.51±0.10(Predicted)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI	1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChIKey	PMXCMJLOPOFPBT-HNNXBMFYSA-N
SMILES	Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C
FDA UNII	YP483E75C4
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P261-P280
WGK Germany	3
HS Code	2933599590
Storage Class	11 - Combustible Solids

Purvalanol a price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540500	Purvalanol A	212844-53-6	1mg	$124	2026-04-30	Buy
Sigma-Aldrich	P4484	Purvalanol A ≥98% (HPLC), powder	212844-53-6	1mg	$144	2023-06-20	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	5mg	$36	2026-04-30	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	10mg	$68	2026-04-30	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	50mg	$303	2026-04-30	Buy

Product number	Packaging	Price	Buy
540500	1mg	$124	Buy
P4484	1mg	$144	Buy
14579	5mg	$36	Buy
14579	10mg	$68	Buy
14579	50mg	$303	Buy

Purvalanol a Chemical Properties, Uses, Production

Description

Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1Reversibly arrests synchronized cells in G1 and G2 phase.2Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5Cell permeable.

Uses

Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.

Definition

ChEBI: Purvalanol A is a purvalanol.

Biological Activity

Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

storage

Store at +4°C

References

[1] SERA T. [Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].[J]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, 52 13 Suppl: 1812-1813.
[2] NATHALIE VILLERBU. Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities[J]. International Journal of Cancer, 2001, 97 6: 761-769. DOI:10.1002/ijc.10125
[3] AJDA COKER-GÜRKAN. Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells.[J]. Oncology reports, 2015: 2761-2770. DOI:10.3892/or.2015.3918
[4] TOMOYA HIKITA Masato O Chitose Oneyama. Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.[J]. Genes to Cells, 2010, 15 10: 1051-1062. DOI:10.1111/j.1365-2443.2010.01439.x
[5] ANDREI GOGA. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC[J]. Nature Medicine, 2007, 13 7: 820-827. DOI:10.1038/nm1606

Purvalanol a Preparation Products And Raw materials

Raw materials

Preparation Products

Purvalanol a Suppliers

Global Suppliers ( 134)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4860	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	989	55

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Ascent Scientific	60
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Bide Pharmatech Ltd.	60
AdooQ Bioscience CHINA	60
Shanghai JiYi Biotechnology Co. Ltd.	55
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55

View Latest Price from Purvalanol a manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Purvalanol A 212844-53-6	$33.00-77.00		99.68%	10g	TargetMol Chemicals Inc.
	2019-09-06	PURVALANOL A 212844-53-6	$1.00	1KG	98%	20kg	Career Henan Chemical Co

Purvalanol A
212844-53-6
$33.00-77.00
99.68%
TargetMol Chemicals Inc.

PURVALANOL A
212844-53-6
$1.00
98%
Career Henan Chemical Co

Purvalanol a Spectrum

PURVALANOL A(212844-53-6)¹HNMR

212844-53-6 (Purvalanol a) Related Search:

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Aminopurvalanol a (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A

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1of4

NG-60 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE (2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL 2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE 2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE CH61386 2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor. PurvalanolA,CDKinhibitor CDKinhibitor PurvalanolA/CH61386 Purvalanol A(NG 60) (R)-Purvalanol A (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)-3-methylbutan-1-ol NG-60, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine Purvalanol A - CAS 212844-53-6 - Calbiochem NG 60;NG60;NG-60 CS-1631 PURVALANOLA, >98% PurvaL 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- PURVALANOL A USP/EP/BP (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol Purvalanol A, 10 mM in DMSO (2R)-2-[[[6-[(3-chlorophenyl)-amino]-9-isopropyl-9H-purine-2-yl]amino]-3-methyl-1-butylol Purvalanol a 212844-53-6 C19H25ClN6O BioChemical Cell Biology Cell Signaling and Neuroscience Cell Cycle Regulators Cell Cycle Apoptosis and Cell Cycle Inhibitors Signalling