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PURVALANOL A

PURVALANOL A structure

CAS No.: 212844-53-6

Chemical Name:: PURVALANOL A

Synonyms: NG-60;PurvaL;CH61386;CS-1631;PURVALANOL A;CDKinhibitor;(R)-Purvalanol A;NG 60;NG60;NG-60;PURVALANOLA, >98%;PurvalanolA/CH61386

CBNumber:: CB5283664

Molecular Formula:: C19H25ClN6O

Molecular Weight:: 388.89

MDL Number:: MFCD02179211

MOL File:: 212844-53-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-30 11:30:00

Product description	Number	Pack Size	Price
Purvalanol A	540500	1mg	$124
Purvalanol A ≥98% (HPLC), powder	P4484	1mg	$144
Purvalanol A ≥98%	14579	5mg	$36
Purvalanol A ≥98%	14579	10mg	$68
Purvalanol A ≥98%	14579	50mg	$303
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PURVALANOL A Properties

Boiling point	590.5±60.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	methylene chloride: 50 mg/mL, clear, colorless
form	powder
pka	14.51±0.10(Predicted)
color	off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI	1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChIKey	PMXCMJLOPOFPBT-HNNXBMFYSA-N
SMILES	Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C
FDA UNII	YP483E75C4
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P261-P280
WGK Germany	3
HS Code	2933599590
Storage Class	11 - Combustible Solids

PURVALANOL A price More Price(83)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540500	Purvalanol A	212844-53-6	1mg	$124	2026-04-30	Buy
Sigma-Aldrich	P4484	Purvalanol A ≥98% (HPLC), powder	212844-53-6	1mg	$144	2023-06-20	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	5mg	$36	2026-04-30	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	10mg	$68	2026-04-30	Buy
Cayman Chemical	14579	Purvalanol A ≥98%	212844-53-6	50mg	$303	2026-04-30	Buy

Product number	Packaging	Price	Buy
540500	1mg	$124	Buy
P4484	1mg	$144	Buy
14579	5mg	$36	Buy
14579	10mg	$68	Buy
14579	50mg	$303	Buy

PURVALANOL A Chemical Properties,Uses,Production

Description

Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1Reversibly arrests synchronized cells in G1 and G2 phase.2Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5Cell permeable.

Uses

Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.

Definition

ChEBI: Purvalanol A is a purvalanol.

Biological Activity

Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

storage

Store at +4°C

References

[1] SERA T. [Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].[J]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, 52 13 Suppl: 1812-1813.
[2] NATHALIE VILLERBU. Cellular effects of purvalanol A: A specific inhibitor of cyclin-dependent kinase activities[J]. International Journal of Cancer, 2001, 97 6: 761-769. DOI:10.1002/ijc.10125
[3] AJDA COKER-GÜRKAN. Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells.[J]. Oncology reports, 2015: 2761-2770. DOI:10.3892/or.2015.3918
[4] TOMOYA HIKITA Masato O Chitose Oneyama. Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.[J]. Genes to Cells, 2010, 15 10: 1051-1062. DOI:10.1111/j.1365-2443.2010.01439.x
[5] ANDREI GOGA. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC[J]. Nature Medicine, 2007, 13 7: 820-827. DOI:10.1038/nm1606

PURVALANOL A Preparation Products And Raw materials

Raw materials

Preparation Products

PURVALANOL A Suppliers

Global( 131)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9951	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from PURVALANOL A manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-29	Purvalanol A 212844-53-6	$33.00-77.00		99.68%	10g	TargetMol Chemicals Inc.
	2019-09-06	PURVALANOL A 212844-53-6	$1.00	1KG	98%	20kg	Career Henan Chemical Co

Purvalanol A
212844-53-6
$33.00-77.00
99.68%
TargetMol Chemicals Inc.

PURVALANOL A
212844-53-6
$1.00
98%
Career Henan Chemical Co

PURVALANOL A Spectrum

PURVALANOL A(212844-53-6)¹HNMR

212844-53-6(PURVALANOL A)Related Search:

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2-Aminopurine 6-ANILINOPURINE PURVALANOL A

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PURVALANOL A NG-60 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE (2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL 2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE 2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE CH61386 2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor. PurvalanolA,CDKinhibitor CDKinhibitor PurvalanolA/CH61386 Purvalanol A(NG 60) (R)-Purvalanol A (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)-3-methylbutan-1-ol NG-60, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine Purvalanol A - CAS 212844-53-6 - Calbiochem NG 60;NG60;NG-60 CS-1631 PURVALANOLA, >98% PurvaL 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- PURVALANOL A USP/EP/BP (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol Purvalanol A, 10 mM in DMSO (2R)-2-[[[6-[(3-chlorophenyl)-amino]-9-isopropyl-9H-purine-2-yl]amino]-3-methyl-1-butylol 212844-53-6 C19H25ClN6O BioChemical Cell Biology Cell Signaling and Neuroscience Cell Cycle Regulators Cell Cycle Apoptosis and Cell Cycle Inhibitors Signalling