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ChemicalBook >> CAS DataBase List >>N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester Structure
N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester structure
CAS No.
1234490-83-5
Chemical Name:
N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester
Synonyms
INX-189;INX 08189;BMS-986094;BMS 986094 hydrate;BMS986094,BMS 986094;INX-08189 BMS 986094;N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester;L-Alanine, N-(2'-C-methyl-6-O-methyl-P-1-naphthalenyl-5'-guanylyl)-, 2,2-dimethylpropyl ester;neopentyl ((((2r,3r,4r,5r)-5-(2-amino-6-methoxy-9h-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-l-alaninate;(2S)-Neopentyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yl)phosphoryl)amino)propanoate
CBNumber:
CB62604352
Molecular Formula:
C30H39N6O9P
Molecular Weight:
658.639221
MDL Number:
MFCD22124897
MOL File:
1234490-83-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester Properties

Boiling point 848.7±75.0 °C(Predicted)
Density 1.47
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 13.01±0.70(Predicted)
form Solid
color White to off-white
InChIKey YFXGICNMLCGLHJ-RSKRLRQZSA-N
SMILES [P](=O)(N[C@@H](C)C(=O)OCC(C)(C)C)(OC[C@H]3O[C@H]([C@@]([C@@H]3O)(O)C)[n]4c5[nH][c](nc(c5nc4)OC)=N)Oc1c2c(ccc1)cccc2
FDA UNII 62F4AD749Y
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2895 BMS-986094 ≥98% (HPLC) 1234490-83-5 5 mg $196 2026-04-30 Buy
Sigma-Aldrich SML2895 BMS-986094 ≥98% (HPLC) 1234490-83-5 25 mg $630 2026-04-30 Buy
Biosynth JZB49083 BMS 986094 hydrate 5mg $340.3 2026-06-04 Buy
Biosynth JZB49083 BMS 986094 hydrate 10mg $544.5 2026-06-04 Buy
Biosynth JZB49083 BMS 986094 hydrate 25mg $1021 2026-06-04 Buy
Product number Packaging Price Buy
SML2895 5 mg $196 Buy
SML2895 25 mg $630 Buy
JZB49083 5mg $340.3 Buy
JZB49083 10mg $544.5 Buy
JZB49083 25mg $1021 Buy

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester Chemical Properties, Uses, Production

Uses

BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2’-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection[1][2].

Biological Activity

BMS-986094 is an orally available prodrug of nucleotide analogue 2′-C-methylguanosine th at potently inhibits Hepatitis C virus (HCV) replication. It is a guanosine nucleotide inhibitor of HCV RNA-dependent RNA polymerase NS5b.

in vivo

BMS-986094 (3-300 mg/kg; p.o.) converts to 2′-C-Me-GTP after oral administration, and 2’-C-MeG in the plasma is proportional to the production of 2’-C-MeGTP in the liver[1].
BMS-986094 (25 mg/kg; p.o.) is efficiently extracts from the portal circulation by the liver following oral administration in cynomolgus monkeys[1].
BMS-986094 (15 or 30 mg/kg/d; p.o. for 3 weeks) administers cynomolgus monkeys, the nucleoside metabolite M2 was the major plasma analyte, and INX-09114 was the highest drug-related species in the heart and kidney[3].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:3, 5, 10, 25 mg/kg
Administration:A single p.o. administration
Result:At doses of ≥5 mg/kg, the concentrations of 2′-C-MeGTP in the liver exceeded the EC90 soon after dosing and remained at or above this level for 72 h.

storage

Store at -20°C

References

[1] Vernachio JH, et, al. INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrob Agents Chemother. 2011 May; 55(5): 1843-51. DOI:10.1128/AAC.01335-10
[2] McGuigan C, et, al. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Bioorg Med Chem Lett. 2010 Aug 15; 20(16): 4850-4. DOI:10.1016/j.bmcl.2010.06.094
[3] Li W, et, al. In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094. Int J Toxicol. 2017 Jan 1; 1091581816683642. DOI:10.1177/1091581816683642

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester Suppliers

Global Suppliers ( 33)
Supplier Tel Email Country ProdList Advantage
Dtchem Laboratories,（Gan Su）Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 774 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 981 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@qq.com China 589 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
NewCan Biotech Limited +86-571-86912261 19975279805 sales@newcanbio.com China 9984 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Supplier Advantage
Dtchem Laboratories,（Gan Su）Co.,Ltd. 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Amadis Chemical Company Limited 58
Kaixin Chemical (Hong Kong) Limited 55
Shanghai Hongye Biotechnology Co. Ltd 58
NewCan Biotech Limited 58
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58

View Latest Price from N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BMS-986094 pictures 2026-07-27 BMS-986094
1234490-83-5
 $2185.00 10g TargetMol Chemicals Inc.
  • BMS-986094 pictures
  • BMS-986094
    1234490-83-5
  • $2185.00
  • TargetMol Chemicals Inc.

1234490-83-5 (N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester) Related Search:

CID 90248010 N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-Methyl-6-O-Methyl-P-phenyl-5'-guanylyl]- L-alanine 1-Methylethyl ester N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester L-Alanine, N-[(2'R)-2'-deoxy-6-O-ethyl-2'-fluoro-4'-C-fluoro-2'-methyl-P-phenyl-5'-guanylyl]-, 1-methylethyl ester E2/envelope protein, hepatitis C virus (278a.a, HEK293, his)
ENVELOPE GLYCOPROTEIN E1 Protein, HCV (HEK293, HIS)

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N-(2'-C-Methyl-6-O-Methyl-P-1-naphthalenyl-5'-guanylyl)-L-alanine 2,2-diMethylpropyl ester INX 08189 L-Alanine, N-(2'-C-methyl-6-O-methyl-P-1-naphthalenyl-5'-guanylyl)-, 2,2-dimethylpropyl ester BMS-986094 INX-189 (2S)-Neopentyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yl)phosphoryl)amino)propanoate (2S)-neopentyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate INX-08189 BMS 986094 (2S)-neopentyl 2-(((((2R,3R,4R,5R)-3,4-dihydroxy-5-(2-imino-6-methoxy-2H-purin-9(3H)-yl)-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate BMS986094,BMS 986094 BMS 986094 hydrate neopentyl ((((2r,3r,4r,5r)-5-(2-amino-6-methoxy-9h-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-l-alaninate 1234490-83-5 C30H39N6O9P