N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE
- CAS No.
- 121749-39-1
- Chemical Name:
- N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE
- Synonyms
- de333;denspm;BENSPM;be3-3-3;DiethylnorsperMine;Bisethyl norspermine;N1,N11-Diethylnorspe;3,7,11,15-Tetraazaheptadecane;N1,N11-Diethylnorspermine4HCl;n(1),n(11)-diethylnorspermine
- CBNumber:
- CB6265962
- Molecular Formula:
- C13H32N4
- Molecular Weight:
- 244.42
- MDL Number:
- MFCD00209844
- MOL File:
- 121749-39-1.mol
| Product description | Number | Pack Size | Price |
| N1,N11-Diethylnorsperminetetrahydrochloride | 0468 | 10 | $171 |
| N1,N11-Diethylnorsperminetetrahydrochloride | 0468 | 50 | $717 |
| N1,N11-Diethylnorspermine | 460258 | 10mg | $403 |
| N1,N11-Diethylnorspermine tetrahydrochloride | 255932 | 10mg | $403 |
| N1,N11-DIETHYLNORSPERMINE 95.00% | API0008719 | 5MG | $500.56 |
| Boiling point | 357.1±10.0 °C(Predicted) |
|---|---|
| Density | 0.877±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| pka | 10.95±0.19(Predicted) |
| FDA UNII | HLI827Z1ST |
N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 0468 | N1,N11-Diethylnorsperminetetrahydrochloride | 121749-39-1 | 10 | $171 | 2021-12-16 | Buy |
| Tocris | 0468 | N1,N11-Diethylnorsperminetetrahydrochloride | 121749-39-1 | 50 | $717 | 2021-12-16 | Buy |
| Usbiological | 460258 | N1,N11-Diethylnorspermine | 121749-39-1 | 10mg | $403 | 2021-12-16 | Buy |
| Usbiological | 255932 | N1,N11-Diethylnorspermine tetrahydrochloride | 121749-39-1 | 10mg | $403 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008719 | N1,N11-DIETHYLNORSPERMINE 95.00% | 121749-39-1 | 5MG | $500.56 | 2021-12-16 | Buy |
N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
N1,N11-Diethylnorspermine (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3][4][5][6].
Biological Activity
Highly potent inducer of spermidine/spermine N 1 -acetyltransferase, able to increase enzyme activity 200-1000 fold.
in vivo
N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].
N1,N11-Diethylnorspermine (120-360 mg/kg, s.c., 4 days) results in prolonged inhibition of tumor growth and long-term tumor regressions in nude athymic mice with MALME-3M melanoma xenografts[5].
N1,N11-Diethylnorspermine (12.5-50 mg/kg, i.v., 5 days) is well tolerated and induces no physical signs in CD rats[6].
IC 50
Caspase 3
References
[1] Schipper RG, et al. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. Prostate. 2000 Sep 1;44(4):313-21. DOI:10.1002/1097-0045(20000901)44:43.0.co;2-d
[2] Holst CM, et al. Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. Anticancer Drugs. 2008 Oct;19(9):871-83. DOI:10.1097/CAD.0b013e32830f902b
[3] Jiang R, et al. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. Int J Oncol. 2007 Aug;31(2):431-40. PMID:17611701
[4] Jiang R, et al. Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells. Cancer Biol Ther. 2007 Oct;6(10):1644-8. DOI:10.4161/cbt.6.10.4800
[5] Bernacki RJ, et al. Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. Clin Cancer Res. 1995 Aug;1(8):847-57. PMID:9816054
[6] Kanter PM, et al. Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs. Anticancer Drugs. 1994 Aug;5(4):448-56. DOI:10.1097/00001813-199408000-00010
N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49946 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44893 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25006 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6075 | 58 |
| Guangzhou Junze Biotechnology Co., Ltd. | 17688489295 | CHINA | 188 | 58 | |
| Guangzhou Weisheng Biotechnology Co., Ltd. | 17765667235 | CHINA | 129 | 58 |
View Lastest Price from N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | N1,N11-Diethylnorspermine
121749-39-1
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
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- N1,N11-Diethylnorspermine
121749-39-1
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.
