ChemicalBook >> CAS DataBase List >>2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]-
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]-
![2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Structure](CAS/20150408/GIF/1226549-39-8.gif)
- CAS No.
- 1226549-39-8
- Chemical Name:
- 2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]-
- Synonyms
- EGFR-IN-9;EGFRIN9,EGFR IN 9;EGFR-IN-9, 10 mM in DMSO;N-{3-[4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]-pyrimidin-5-yl]phenyl}acrylamide;N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide;2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]-
- CBNumber:
- CB62667326
- Molecular Formula:
- C29H24N4O3
- Molecular Weight:
- 476.52586
- MDL Number:
- MFCD25977045
- MOL File:
- 1226549-39-8.mol
Last updated:2025-04-18 09:51:19
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Properties
| Boiling point | 719.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.312±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (209.85 mM; Need ultrasonic) |
| form | Solid |
| pka | 13.24±0.70(Predicted) |
| color | Off-white to light yellow |
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Chemical Properties,Uses,Production
Uses
EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity[1].
IC 50
EGFR (WT): 7 nM (IC50); EGFRL858R/T790M: 28 nM (IC50)
References
[1] Coumar MS, et al. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor leadidentification. J Med Chem. 2010 Jul 8;53(13):4980-8. DOI:10.1021/jm1000198
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Suppliers
Global( 12)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| NANJING TOMMLAB PHARMATECH Co.,LTD | -- | litianang@caremo.com.cn | China | 498 | 58 |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10505 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Aobolihui | 0917-18691729 18691729963 | 2553382659@qq.com | China | 4742 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Hubei Rhema Reference Materials Technology Co., Ltd. | 15787875101 | 645977340@qq.com | China | 9995 | 58 |
| Shenzhen Zuoke Biotechnology Co., Ltd. | 13532174601 | CHINA | 109 | 58 |
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- Spectrum
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]-
N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
EGFR-IN-9
N-{3-[4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]-pyrimidin-5-yl]phenyl}acrylamide
EGFRIN9,EGFR IN 9
EGFR-IN-9, 10 mM in DMSO
1226549-39-8
