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5-Methoxybenzothiazole

5-Methoxybenzothiazole Structure
5-Methoxybenzothiazole structure
CAS No.
2942-14-5
Chemical Name:
5-Methoxybenzothiazole
Synonyms
5-Methoxybenzothiazole;Benzothiazole,5-Methoxy-;5-Methoxybenzo[d]thiazole;5-Methoxy-1,3-benzothiazol;5-Methoxy-1,3-benzothiazole;Benzothiazole, 5-methoxy- (7CI,8CI,9CI)
CBNumber:
CB6271174
Molecular Formula:
C8H7NOS
Molecular Weight:
165.21
MDL Number:
MFCD06659660
MOL File:
2942-14-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:09
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5-Methoxybenzothiazole Properties

Melting point 38.5-39 °C(Solv: benzene (71-43-2))
Boiling point 274.4±13.0 °C(Predicted)
Density 1.268±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 1.44±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  29342000

5-Methoxybenzothiazole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth CAA94214 5-Methoxy-1,3-benzothiazole 2942-14-5 1g $354 2026-06-04 Buy
Biosynth CAA94214 5-Methoxy-1,3-benzothiazole 2942-14-5 10g $2006 2026-06-04 Buy
Matrix Scientific 311667 5-Methoxybenzo[d]thiazole 2942-14-5 250.00mg $52 2026-05-19 Buy
Matrix Scientific 311667 5-Methoxybenzo[d]thiazole 2942-14-5 1.00g $147 2026-05-19 Buy
Matrix Scientific 311667 5-Methoxybenzo[d]thiazole 2942-14-5 5.00g $493 2026-05-19 Buy
Product number Packaging Price Buy
CAA94214 1g $354 Buy
CAA94214 10g $2006 Buy
311667 250.00mg $52 Buy
311667 1.00g $147 Buy
311667 5.00g $493 Buy

5-Methoxybenzothiazole Chemical Properties, Uses, Production

Uses

5-Methoxybenzo[d]thiazole is used as a reactant in the preparation of 3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamides as a potent dipeptidyl peptidase IV inhibitors.

Synthesis

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

54346-87-1

5-METHOXYBENZOTHIAZOLE

2942-14-5

General procedure for the synthesis of 5-methoxybenzo[d]thiazole from 5-methoxy-2-benzothiazolamine: 5-methoxybenzo[d]thiazol-2-amine (397 mg, 2.2 mmol) was dissolved in tetrahydrofuran (THF, 16 mL). Tert-butyl nitrite (0.375 mL, 3.17 mmol) was slowly added to the solution at 60 °C and the reaction mixture was continuously stirred overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The crude product obtained was purified by silica gel column chromatography (SNAP 10 g column, eluent was hexane/ethyl acetate mixed solvent) to finally obtain 5-methoxybenzo[d]thiazole (281 mg, 77.3% yield) as a yellow solid.

References

[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0376
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 6, p. 1976 - 1980

5-Methoxybenzothiazole Preparation Products And Raw materials

Raw materials

Formic acid 5-Methoxy-1,3-benzothiazol-2-amine 2-Amino-4-methoxybenzenethiol tert-Butyl nitrite Tetrahydrofuran

Preparation Products

5-Methoxybenzothiazole Suppliers

Global Suppliers ( 44)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Shanghai Boyners Pharm-Tech Co., Ltd. 13817873692 mkt@boynerspharm.com China 1707 55
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Yancheng Schiemann Biological Technology Co.,Ltd 0515-88280676; 18921872653 sales@ximanbio.com China 1524 56
BioPharmaMatrix,Inc. 0510-86010668 13395169561; sales@biopharmamatrix.com China 5010 55
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Shanghai Huaxing Biological Technology Co., Ltd. 18621295758; 18621295758 1449085402@qq.com China 1973 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Bide Pharmatech Ltd. 60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Shanghai Boyners Pharm-Tech Co., Ltd. 55
JW & Y Pharmlab Co., Ltd. 58
Yancheng Schiemann Biological Technology Co.,Ltd 56
BioPharmaMatrix,Inc. 55
Shanghai SuperLan Chemcial Technique Centre 58
Amadis Chemical Company Limited 58
Shanghai Huaxing Biological Technology Co., Ltd. 55

5-Methoxybenzothiazole Spectrum

5-METHOXYBENZOTHIAZOLE(2942-14-5)1HNMR

2942-14-5 (5-Methoxybenzothiazole) Related Search:

5,6-Dimethoxy-2-methyl-benzothiazole 2-Mercapto-5-methoxybenzothiazole 5-Methoxy-2-methylbenzothiazole Benzothiazole, 5-ethoxy-2,6-dimethyl- (9CI) 2-Methyl-5-methoxy-6-methylthio benzothiazole
Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI) 5-Methoxy-1,3-benzothiazol-2-amine 5-Methoxy-2-methyl-3-(3-sulfopropyl)benzothiazolium inner salt 3-Ethyl-2-(3-(3-ethyl-5,6-methylenedioxy-2-benzothiazolinylidene)-1-propenyl-5,6-methylenedioxy) benzothiazolium ethyl sulfate 3-Carboxyethyl-2-(2-((3-carboxyethyl-5-methyl-6-methoxy-2-benzothiazolinylidene) methyl)-1-butenyl)-5-methyl-6-methoxy benzothiazolium bromide
3-Ethyl-2-(2-methoxy-5-(3-ethyl-5,6-methylenedioxy benzothiazolinylidene)-1,3-pentadienyl)-5,6-methylenedioxy benzothiazolium bromide 3-Carboxyethyl-2-(2-((3-carboxyethyl-5-methyl-6-methoxy-2-benzothiazolinylidene) methyl)-1-butenyl)-5-methyl-6-methoxy benzothiazolium iodide 5-Methoxy-3-(3-sulfopropyl)-2-(2-[(5-methoxy-3-(3-sulfopropyl)-2,3-dihydro-benzothiazol-2-ylidene)methyl]-1-butenyl)-benzothiazolium inner salt pyridinium salt 5-Methoxy-3-(3-sulfopropyl)-2-[(1-6-methyl-(3-sulfopropyl)-2(1H)-quinolylidene)methyl]benzothiazolium inner salt potassium salt trihydrate AURORA KA-327
3-(3-Sulfopropyl)-2-([5-methoxy-3-(3-sulfopropyl)-2,3-dihydro-benzothiazol-2-ylidne]methyl)-naphtho[1,2-d]-thiazolium inner salt triethylammonium salt 3-Ethyl-2-[5-(3-ethyl-5-methoxy-6-methyl mercapto-2-benzothiazolinylidene)-1,3-pentadienyl)-5-methoxy-6-methylmercapto-benzothiazolium paratoluenesulfonate 3-(2-Hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5-methoxy-2-benzothiazolylidene]methyl]-1-butenyl]-5-methoxybenzothiazolium tosylate

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Benzothiazole,5-Methoxy- 5-Methoxybenzo[d]thiazole Benzothiazole, 5-methoxy- (7CI,8CI,9CI) 5-Methoxy-1,3-benzothiazol 5-Methoxy-1,3-benzothiazole 5-Methoxybenzothiazole 2942-14-5 BENZOTHIAZOLE