ChemicalBook >> CAS DataBase List >>5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE structure

CAS No.: 54346-87-1

Chemical Name:: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

Synonyms: 5-methoxybenzo[d]thiazol-2-amine;5-Methoxy-2-benzothiazolamine;5-methoxybenzothiazol-2-amine;2-Amino-5-methoxybenzothiazole;2-Benzothiazolamine, 5-methoxy-;5-METHOXY-BENZOTHIAZOL-2-YLAMINE;5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE;2-Benzothiazolamine,5-methoxy-(9CI);5-Methoxy-1,3-benzothiazole-2-amine;2-Amino-5-methoxy-1,3-benzothiazole 97%

CBNumber:: CB4197250

Molecular Formula:: C8H8N2OS

Molecular Weight:: 180.23

MDL Number:: MFCD00464314

MOL File:: 54346-87-1.mol

MSDS File:: SDS

Last updated:2026-05-28 02:09:36

Request For Quotation

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Properties

Melting point	154 °C
Boiling point	347.5±34.0 °C(Predicted)
Density	1.359±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	4.53±0.10(Predicted)
Appearance	White to off-white Solid
FDA UNII	9H7992E7HJ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xi,Xn
Risk Statements	22
HazardClass	IRRITANT
HS Code	29342000

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	ECA34687	5-Methoxy-1,3-benzothiazol-2-amine	54346-87-1	10g	$354	2026-06-04	Buy
Apolloscientific	OR2965	2-Amino-5-methoxy-1,3-benzothiazole 98%	54346-87-1	100mg	$21	2026-06-04	Buy
Apolloscientific	OR2965	2-Amino-5-methoxy-1,3-benzothiazole 98%	54346-87-1	1g	$90	2026-06-04	Buy
Apolloscientific	OR2965	2-Amino-5-methoxy-1,3-benzothiazole 98%	54346-87-1	5g	$256	2026-06-04	Buy
Apolloscientific	OR2965	2-Amino-5-methoxy-1,3-benzothiazole 98%	54346-87-1	25g	$912	2026-06-04	Buy

Product number	Packaging	Price	Buy
ECA34687	10g	$354	Buy
OR2965	100mg	$21	Buy
OR2965	1g	$90	Buy
OR2965	5g	$256	Buy
OR2965	25g	$912	Buy

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Chemical Properties,Uses,Production

Synthesis

37014-08-7

54346-87-1

1. Preparation of 5-methoxy-benzothiazol-2-ylamine: To a suspension of (3-methoxyphenyl)thiourea (1.822 g, 10 mmol) in dichloromethane (20 mL) was slowly added dropwise a solution of bromine (1.76 g, 11 mmol) in 10 mL of trichloromethane at 0 °C for 30 min. The reaction mixture was stirred at room temperature for 3 hours and then heated to reflux for 1 hour. After completion of the reaction, the precipitate was collected by filtration and washed with dichloromethane. The solid was suspended in saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, dried with magnesium sulfate and concentrated to give a white solid product (1.716 g, 95% yield). 2. Preparation of 2-amino-benzothiazol-5-ol: 5-methoxy-benzothiazol-2-ylamine (1.716g) obtained in the previous step was suspended in 16mL of 48% aqueous hydrobromic acid, and the reaction was heated in an oil bath at 105°C for 10 hours. After the reaction was cooled to room temperature, the precipitate was collected by filtration and washed with acetone. The solid in the filtrate was suspended in saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phase was dried with magnesium sulfate and concentrated to give a white solid product (0.986 g, 63% yield). 3. Synthesis of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[6-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea hydrochloride [Compound B12]: 2-amino-benzothiazol-5-ol obtained from the previous step was used as a raw material, and the reaction was carried out according to the literature method. The product was characterized by nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6) and liquid chromatography-mass spectrometry (LC-MS): 1H NMR (DMSO-d6) δ 11.1 (br, 1H), 9.69 (br, 1H), 9.28 (br, 1H), 8.71 (s, 1H), 7.97 (d, 1H), 7.79 (d and s, 3H), 7.56 (d, 2H), 7.56 (d, 2H), 7.13 (d, 2H). 2H), 7.13 (dd, 1H), 6.53 (s, 1H), 4.56 (t, 2H), 3.98 (m, 2H), 3.82 (t, 2H), 3.65 (m, 2H), 3.55 (m, 2H), 3.25 (m, 2H), 1.31 (s, 9H); LC-MS: ESI 561 (M + H)+.

References

[1] Patent: US2007/232604, 2007, A1. Location in patent: Page/Page column 40
[2] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1136 - 1148
[3] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1956, vol. 22, p. 363,365
[4] Chem.Abstr., 1957, p. 4358
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9814 - 9824

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE synthesis

Synthesis of 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE from 1-(3-METHOXYPHENYL)-2-THIOUREA

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

2,4,6(1H,3H,5H)-Pyrimidinetrione,5-amino-1,3-dimethyl- m-Anisidine hydrochloride 1-(3-METHOXYPHENYL)-2-THIOUREA Potassium thiocyanate m-Anisidine

Chloroform Dichloromethane

1of2

Preparation Products

2(3H)-Benzothiazolone,5-methoxy-,hydrazone(9CI)

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Suppliers

Global( 124)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	4905	55
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Nanjing Duolong Bio-tech Co.,Ltd.	18905173768	52513593@qq.com	China	2337	50
Nanjing Chalf-Pharm Technology Co., Ltd.	025-57018978 18251899859	sales@chalf-pharm.com	China	5855	50

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jinan Trio PharmaTech Co., Ltd.	62
Shanghai Yolne Chemical Co., Ltd.	55
Shanghai Raise Chemical Technology Co.,Ltd	55
Clearsynth Labs Limited	58
Bide Pharmatech Ltd.	60
Nanjing Duolong Bio-tech Co.,Ltd.	50
Nanjing Chalf-Pharm Technology Co., Ltd.	50

View Lastest Price from 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-01-15	5-Methoxybenzo[d]thiazol-2-amine 54346-87-1		1KG	97.3%	100 tons	Honest Joy Holdings Limited
	2019-07-06	5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 54346-87-1	$1.00	1KG	98%	200KG	Career Henan Chemical Co

5-Methoxybenzo[d]thiazol-2-amine
54346-87-1
$0.00
97.3%
Honest Joy Holdings Limited

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE
54346-87-1
$1.00
98%
Career Henan Chemical Co

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Spectrum

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE(54346-87-1)¹HNMR

54346-87-1(5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE)Related Search:

4-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 6-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 5,6-DIPROPOXY-1,3-BENZOTHIAZOL-2-AMINE 5,6-DIMETHOXY-1,3-BENZOTHIAZOL-2-AMINE

1,3-Dioxolo[4,5-f]benzothiazol-6-amine(9CI) 5,6-DIETHOXY-1,3-BENZOTHIAZOL-2-AMINE 5-CHLORO-6-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 2-Hydrazino-6,7-dihydro[1,4]dioxino[2,3-f][1,3]benzothiazole 6-Hydrazino[1,3]dioxolo[4,5-f][1,3]benzothiazole

5-ETHOXY-1,3-BENZOTHIAZOL-2-YLAMINE 5,6-BIS(DIFLUOROMETHOXY)BENZOTHIAZOL-2-YLAMINE AURORA KA-64 SALOR-INT L129402-1EA SALOR-INT L219851-1EA

5-PHENOXY-N-[2-(TRIFLUOROMETHYL)PHENYL]-1,3-BENZOTHIAZOL-2-AMINE 3-(5-METHOXY-BENZOTHIAZOL-2-YL)-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID SALOR-INT L127949-1EA

1of4

5-METHOXY-BENZOTHIAZOL-2-YLAMINE 5-methoxybenzothiazol-2-amine 2-Benzothiazolamine,5-methoxy-(9CI) 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 5-Methoxy-2-benzothiazolamine 2-Amino-5-methoxybenzothiazole 5-Methoxy-1,3-benzothiazole-2-amine 2-Amino-5-methoxy-1,3-benzothiazole 97% 2-Benzothiazolamine, 5-methoxy- 5-methoxybenzo[d]thiazol-2-amine 54346-87-1 Thiazoles, Isothiazoles & Benzothiazoles Amines Thiazoles, Isothiazoles &Benzothiazoles BENZOTHIAZOLE