1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
- CAS No.
- 1190865-44-1
- Chemical Name:
- 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
- Synonyms
- 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one;Sealed in dry,Room Temperature;3',5'-DICHLORO-2,2,2,4'-TETRAFLUOROACETOPHENONE;2,2,2-Trifluoro-3',5'-dichloro-4'-fluoroacetophenone;1-(3,5-Dichloro-4-fluoropheny)-2,2,2-trifluoroethanone;1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone;Ethanone, 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-;1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (Sarolaner intermediate）;1-(3,5-dichloroChemicalbook-4-fluorophenyl)-2,2,2-trifluoroethan-1-one(Sarolanerintermediate）;1(3,5Dichloro4fluorophenyl)2,2,2trifluoroethanone,1 (3,5 Dichloro 4 fluorophenyl) 2,2,2 trifluoroethanone
- CBNumber:
- CB62716626
- Molecular Formula:
- C8H2Cl2F4O
- Molecular Weight:
- 261.0004928
- MDL Number:
- MFCD23382507
- MOL File:
- 1190865-44-1.mol
- MSDS File:
- SDS
| Boiling point | 282.5±40.0 °C(Predicted) |
|---|---|
| Density | 1.577±0.06 g/cm3(Predicted) |
| vapor pressure | 20-2750Pa at 20-37.8℃ |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C8H2Cl2F4O/c9-4-1-3(2-5(10)6(4)11)7(15)8(12,13)14/h1-2H |
| InChIKey | NSWPERXXSPCRCT-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(Cl)=C(F)C(Cl)=C1)C(F)(F)F |
| LogP | 2.57 |
| Surface tension | 61.3mN/m at 1g/L and 20℃ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2914790090 |
| REACH Registrations | Active |
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC49287 | 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone ≥95% | 1190865-44-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC49287 | 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone ≥95% | 1190865-44-1 | 5g | $58 | 2026-06-04 | Buy |
| Apolloscientific | PC49287 | 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone ≥95% | 1190865-44-1 | 25g | $116 | 2026-06-04 | Buy |
| Matrix Scientific | 208048 | 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone | 1190865-44-1 | 1.00g | $624 | 2026-05-18 | Buy |
| Matrix Scientific | 208048 | 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone | 1190865-44-1 | 5.00g | $2257 | 2026-05-18 | Buy |
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Chemical Properties, Uses, Production
Uses
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone can be used as a pesticide intermediate, mainly in the synthesis of sarolaner.
Synthesis
340-07-8
17318-08-0
1190865-44-1
The general procedure for the synthesis of 3,5-dichloro-4-fluorotrifluoroacetylbenzene from 1-trifluoroacetylpiperidine and 3,5-dichloro-4-fluorobromobenzene is as follows: Intermediate 3: Synthesis of 1-(4-chloro-3,5-difluorophenyl)-2,2,2-trifluoroacetophenone 1. 5-bromo-2-fluoro-1,3-dichlorobenzene (7.0 g, 28.7 mmol) was dissolved in THF (50 mL) under argon protection and stirred at room temperature. 2. isopropylmagnesium chloride lithium chloride complex (24.3 mL, 1.3 M solution in THF, 1.1 equiv) was added slowly over 1 min and stirring was continued at room temperature for 30 min. 3. The reaction system was cooled to 0 °C and piperidine trifluoroacetamide (5.6 mL, 1.32 equiv.) was added over about 1 min. 4. The reaction mixture was stirred at room temperature for 2 hours. 5. Upon completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution (50 mL). 6. The reaction mixture was extracted with methyl tert-butyl ether (MTBE, 2 x 50 mL). 7. The organic phases were combined and concentrated under reduced pressure to remove the solvent. 8. The crude product was purified by chromatography on a 12 g Redi-Sep column with the eluent being a heptane solution of 0 to 50% ethyl acetate to give 3.5 g of 1-(4-chloro-3,5-difluorophenyl)-2,2,2-trifluoroethanone. Product Characterization: 1H-NMR (400 MHz, CDCl3) δ ppm 8.06 (dd, 2H, J1 = 6.2 Hz, J2 = 0.9 Hz).
References
[1] Patent: WO2016/115315, 2016, A1. Location in patent: Page/Page column 30; 31
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Preparation Products And Raw materials
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Zhishang Chemical Co. LTD | 15689709505 15508639737 | 2138533552@qq.com | China | 102 | 58 |
| Shandong Wanhe Chemical Technology Co., Ltd | 18854132367 | sales@wanhechemical.com | China | 205 | 58 |
| Changzhou Yuanhe Biopharmaceutical Co., Ltd | 15995091686 | 15995091686@163.com | China | 82 | 58 |
| Shandong Mingfeng Pharmaceutical and Technology Co. Ltd | 053155551677 15315114555 | 1345456643@qq.com | China | 298 | 58 |
| CHENGHUI PHARMACEUTICAL GROUP LTD | 053158897070 15550412551 | market@jnchsd.com | China | 241 | 58 |
| Shandong Yizhi Medical Technology Co., LTD | 13287715206 15508629772 | 2786175817@qq.com | China | 65 | 58 |
| Shanghai Record Pharmaceuticals Co., Ltd. | 021-62506791 17321028908 | record@recordpharm.com | China | 28 | 58 |
| Nanjing Intermate Technology Co., Ltd | 18501091076 | 57715449@qq.com | China | 102 | 58 |
| Shandong Scientific Research Pharmaceutical Co., Ltd | 13053388919 | 3908585847@qq.com | China | 83 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
1190865-44-1
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-04-22 | 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
1190865-44-1
|
$31.00-81.00 | 99.60% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-19 | 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone
1190865-44-1
|
1kg | 99% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
1190865-44-1
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
1190865-44-1
- $31.00-81.00
- 99.60%
- TargetMol Chemicals Inc.
-
- 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone
1190865-44-1
- $0.00
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
