TP0903
- CAS No.
- 1341200-45-0
- Chemical Name:
- TP0903
- Synonyms
- TP-0903;Dubermatinib;TP0903;CS-1642;Apraclonidina;Apraclonidinum;TP 0903;TP0903;Dubermatinib(TP-0903);TP-0903(Dubermatinib);2-[[5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
- CBNumber:
- CB62745451
- Molecular Formula:
- C24H30ClN7O2S
- Molecular Weight:
- 516.06
- MDL Number:
- MFCD28502172
- MOL File:
- 1341200-45-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >198°C (dec.) |
|---|---|
| Boiling point | 664.7±65.0 °C(Predicted) |
| Density | 1.347±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 7.60±0.10(Predicted) |
| form | Solid |
| color | Off-White to Light Yellow |
| InChIKey | YUAALFPUEOYPNX-UHFFFAOYSA-N |
| SMILES | C1(S(N(C)C)(=O)=O)=CC=CC=C1NC1C(Cl)=CN=C(NC2=CC=C(CN3CCN(C)CC3)C=C2)N=1 |
| FDA UNII | 14D65TV20J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
TP0903 price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28757 | TP-0903 ≥98% | 1341200-45-0 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 28757 | TP-0903 ≥98% | 1341200-45-0 | 5mg | $168 | 2026-04-30 | Buy |
| Cayman Chemical | 28757 | TP-0903 ≥98% | 1341200-45-0 | 10mg | $297 | 2026-04-30 | Buy |
| Cayman Chemical | 28757 | TP-0903 ≥98% | 1341200-45-0 | 25mg | $653 | 2026-04-30 | Buy |
| Usbiological | 474201 | TP-0903 | 1341200-45-0 | 100mg | $1677 | 2026-06-03 | Buy |
TP0903 Chemical Properties, Uses, Production
Uses
TP-0903 is an AXL kinase inhibitor.
Biological Activity
axl and other tam family members are known to be involved in maintaining the mesenchymal phenotype in cancer cells. mesenchymal cells have increased invasion and migratory properties, enhanced cell survival in stressed environments, as well as increased resistance to targeted therapies. tp-0903 is a potent anti-cancer agent targeting the axl receptor tyrosine kinase.
in vitro
on the basis of the potency of tp-0903 in biochemical assays, its activity in cell-based studies was evaluated. tp-0903 showed extremely potent activity in cell viability assays against the pancreatic cancer cell line psn-1. more importantly, tp-0903 was evaluated for its ability to block gas6-mediated activation of axl in pancreatic cancer cells. psn-1 cells were serum-starved and then stimulated with gas6 in the presence of various concentrations of tp-0903 [1].
in vivo
tp-0903 restores sensitivity to erlotinib in cell-based and preclinical animal models of cancer by reversing the mesenchymal phenotype driving resistance [2].
IC 50
0.027 μm against axl
References
[1] mollard a, warner sl, call lt, wade ml, bearss jj, verma a, sharma s, vankayalapati h, bearss dj. design, synthesis and biological evaluation of a series of novel axl kinase inhibitors. acs med chem lett. 2011 dec 8;2(12):907-912.
[2] toleropharmaceuticals, inc–tp-0903. http://www.toleropharmaceuticals.com/tp-0903.html.
TP0903 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4688 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. | 023-89130144 18523560356 | zhyong1011@163.com | China | 297 | 58 |
View Latest Price from TP0903 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Dubermatinib
1341200-45-0
|
$30.00-83.00 | 99.58% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-31 | 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
1341200-45-0
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- Dubermatinib
1341200-45-0
- $30.00-83.00
- 99.58%
- TargetMol Chemicals Inc.
-
- 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
1341200-45-0
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
