Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Spermine

Spermine

Spermine Structure
Spermine structure
CAS No.
71-44-3
Chemical Name:
Spermine
Synonyms
SPERMINE TETRAHYDROCHLORIDE;Spermin;N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine);NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%
CBNumber:
CB6275334
Molecular Formula:
C10H26N4
Molecular Weight:
202.34
MDL Number:
MFCD00012914
MOL File:
71-44-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 14:29:32
Request For Quotation

Spermine Properties

Melting point 28-30 (lit.)
Boiling point 150 °C/5 mmHg (lit.)
Density 0.937
refractive index 1.4850 (estimate)
Flash point >230 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form powder
pka 10.88±0.19(Predicted)
color Colorless to off-white
biological source microbial
synthetic
Water Solubility Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive Air Sensitive & Hygroscopic
Merck 14,8743
BRN 1751791
Stability Hygroscopic
Cosmetics Ingredients Functions SKIN CONDITIONING
InChI 1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
SMILES [H]N(CCCN)CCCCN([H])CCCN
LogP -0.543 (est)
CAS DataBase Reference 71-44-3(CAS DataBase Reference)
FDA UNII 2FZ7Y3VOQX
NIST Chemistry Reference Spermine(71-44-3)
EPA Substance Registry System 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)
UNSPSC Code 85151701
NACRES NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318-H314
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xi,C
Risk Statements  36/38-34
Safety Statements  26-36-45-36/37/39-27
RIDADR  UN 3259 8/PG 2
WGK Germany  3
RTECS  EJ7230000
F  3-10
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29212900
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
NFPA 704
1
3 1

Spermine price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 85590 Spermine ≥99.0% (GC) 71-44-3 5g $365 2026-04-30 Buy
Sigma-Aldrich 55513 Spermine analytical standard 71-44-3 100mg $81.5 2026-04-30 Buy
TCI Chemical P3251 Spermine 71-44-3 1G $58 2026-04-30 Buy
TCI Chemical P3251 Spermine 71-44-3 5G $173 2026-04-30 Buy
Cayman Chemical 18041 Spermine ≥95% 71-44-3 1g $41 2026-04-30 Buy
Product number Packaging Price Buy
85590 5g $365 Buy
55513 100mg $81.5 Buy
P3251 1G $58 Buy
P3251 5G $173 Buy
18041 1g $41 Buy

Spermine Chemical Properties, Uses, Production

Description

Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.

Chemical Properties

White to slightly off-white powder crysta

Uses

immune modulator

Uses

Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).

Uses

Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes

Definition

ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.

General Description

Spermineis a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

+4°C (desiccate)

References

[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.

Spermine Preparation Products And Raw materials

Raw materials

Coconut oil

Preparation Products

3-aminopropanal N2,N3,N4-Tris-(tert-butyloxycarbonyl)-1,5,10,14-tetra-aza-quatrodecane Spermine tetrahydrochloride Spermidine

Spermine Suppliers

Global Suppliers ( 410)
Supplier Tel Email Country ProdList Advantage
Suzhou Uugene Biopharma Co., Ltd. 0512-69561956 18015581618 sales@uugene.com China 111 55
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Chongqing Botao Biotechnology Co., LTD 15223382610 danny@chemdad.com China 2034 58
Nanjing Tengyi Biotechnology Co., Ltd 17714337195 sales@tybiochem.com China 683 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Suzhou Uugene Biopharma Co., Ltd. 55
Aikon International Limited 58
Chongqing Botao Biotechnology Co., LTD 58
Nanjing Tengyi Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

Related articles

View Latest Price from Spermine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spermine pictures 2026-09-11 Spermine
71-44-3
 1kg 98.2% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Spermine pictures 2026-09-02 Spermine
71-44-3
 $3.00-8.00 1KG 99% Henan Fengda Chemical Co., Ltd
Spermine pictures 2026-08-25 Spermine
71-44-3
 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
  • Spermine pictures
  • Spermine
    71-44-3
  • 98.2%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Spermine pictures
  • Spermine
    71-44-3
  • $3.00-8.00
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • Spermine pictures
  • Spermine
    71-44-3
  • $0.00
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd

Spermine Spectrum

Spermine(71-44-3)1HNMRSpermine(71-44-3)IR1

71-44-3 (Spermine) Related Search:

N,N-Diisopropylethylamine Polyaminopropyl biguanide 1,4-Diaminobutane Histamine Ethanethiol
Diisopropylamine Diallylamine Spermidine Triallylamine Succinic acid
Allylamine L(+)-Arginine O,O-Dimethyl phosphoramidothioate Spermine tetrahydrochloride Spermine tetrahydrochloride, [terminal methylene-3H]
Spermine [14C]Spermine tetrahydrochloride

1of4

SPERMINE HYDROCHLORIDE n,n’-bis(3-aminopropyl)-4-butanediamine n,n’-bis(3-aminopropyl)-4-diaminobutane Spermin N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE NEURIDINE HYDROCHLORIDE NEURIDINE TETRAHYDROCHLORIDE MUSCULAMINE HYDROCHLORIDE MUSCULAMINE TETRAHYDROCHLORIDE Spermine SOYASAPONIN IV(SH) Spermine,N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine Spermine >98% N,N'-Bis(3-aminopropyl)-1,4-butanediamine GERONTINE TETRAHYDROCHLORIDE DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE 1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE 4,9-diazadodecamethylenediamine N,N-Bis(3-aminopropyl)-1,4-diaminobutane~Gerontine~Musculamine~Neuridine Spermine N,N-Bis(3-aminopropyl)-1,4-diaminobutane SPERMINE FREE BASE CELL CULTURE TESTED Spermine,97% Sperminedihydrate,97% BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE NSC 268508 SPERMINE FREE BASE extrapure 1,4-Bis(aminopropyl)butanediamine 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)- 4,9-Diaza-1,12-dodecanediamine 4,9-Diazadodecane-1,12-diamine N,NBis(2-aminopropyl)-1,4-butane-diamine, N,NBis(2-aminopropyl)tetramethylenediamine SPERMINE >= 99.0% (GC) bis(propane-1,3-diamine) N1,N1'-(Butane-1,4-diyl) 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)- DJtPAT Spermine CAS 71-44-3 with Best Price Fast Delivery Good Quality Spermine (NSC-268508 (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl}) amine Spermine, ≥99% (GC) N,N'-bis(3-aminopropyl)butane-1,4-diamine Gerontine|||Musculamine|||4,9-Diaza-1,12-dodecanediamine|||NSC 268508|||Neuridine Spermine in methanol Spermine (Standard) N,N'-bis(3-aminopropyl)-1,4-butyldiamine Gadobutrol Impurity 180 Monomer SPERMINE TETRAHYDROCHLORIDE N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine) 71-44-3 77-44-3 H2NCH23NHCH23NH2 NH2CH23NHCH24NHCH23NH2 H2NCNHNHCH24NH2 C10H26N4