R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
- CAS No.
- 67287-39-2
- Chemical Name:
- R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
- Synonyms
- SKF 81297C;SKF-81297 HBr;R(+)-SKF-81297 HYDROBROMIDE;9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol:hydrobromide;6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide;(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide;R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
- CBNumber:
- CB6294186
- Molecular Formula:
- C16H16ClNO2.BrH
- Molecular Weight:
- 370.67
- MDL Number:
- MFCD00671792
- MOL File:
- 67287-39-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >256°C (dec.) |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | H2O: 6 mg/mL |
| form | solid |
| color | white to off-white |
| FDA UNII | L86RFQ3NSD |
R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15067 | (±)-SKF 81297 (hydrobromide) ≥98% | 67287-39-2 | 5mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 15067 | (±)-SKF 81297 (hydrobromide) ≥98% | 67287-39-2 | 10mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 15067 | (±)-SKF 81297 (hydrobromide) ≥98% | 67287-39-2 | 25mg | $240 | 2026-04-30 | Buy |
| Usbiological | 256680 | SKF 81297 hydrobromide Asreported | 67287-39-2 | 10mg | $480 | 2026-06-03 | Buy |
| Usbiological | 256680 | SKF 81297 hydrobromide Asreported | 67287-39-2 | 50mg | $1338 | 2026-06-03 | Buy |
R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Chemical Properties, Uses, Production
Uses
SKF 81297C is a dopamine D1 agonist (1).
Hazard
A poison.
Biological Activity
skf 81297 hydrobromide is a selective agonist of the dopamine d1-like receptor, with a ki value of 1.9 nm. the dopamine d1-like receptors, consisting of d1 and d5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. the dopamine d1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.1. neumeyer jl, kula ns, bergman j, baldessarini rj. receptor affinities of dopamine d1 receptor-selective novel phenylbenzazepines. european journal of pharmacology, 2003, 474(2-3): 137-140.2. undieh as. pharmacology of signaling induced by dopamine d(1)-like receptor activation. pharmacology & therapeutics, 2010, 128(1): 37-60.3. vermeulen rj, drukarch b, sahadat mc, et al. the dopamine d1 agonist skf 81297 and the dopamine d2 agonist ly 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. movement disorders, 1994, 9(6): 664-672.
in vivo
SKF 81297 hydrobromide (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1].
| Animal Model: | Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] |
| Dosage: | 0.05-0.3 mg/kg |
| Administration: | Injected intramuscularly (i.m.), once |
| Result: | Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys. |
IC 50
D1 Receptor
storage
+4°C (desiccate)
R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | SKF 81297 hydrobromide
67287-39-2
|
$213.00-483.00 | 99.52% | 10g | TargetMol Chemicals Inc. |
-
- SKF 81297 hydrobromide
67287-39-2
- $213.00-483.00
- 99.52%
- TargetMol Chemicals Inc.
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