SH-6
- CAS No.
- 701976-55-8
- Chemical Name:
- SH-6
- Synonyms
- SH-6;PIA 6;AKT INHIBITOR III;SH 6 (enzyme inhibitor);D-2,3-DIDEOXY-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE];D-2,3-Dideoxy-2-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];Phosphoric acid, mono[(2R)-2-methoxy-3-(octadecyloxy)propyl] mono[(1R,2R,3S,4R)-2,3,4-trihydroxycyclohexyl] ester
- CBNumber:
- CB6298265
- Molecular Formula:
- C28H57O9P
- Molecular Weight:
- 568.72
- MDL Number:
- MFCD06412428
- MOL File:
- 701976-55-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | MP59677 | 1mg | $449.76 |
| Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | MP59677 | 2mg | $749.6 |
| Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | MP59677 | 5mg | $1461.7 |
| Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | MP59677 | 10mg | $2623.6 |
| SH-6 | S1010-74A | 500ug | $462 |
SH-6 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | MP59677 | Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | 701976-55-8 | 1mg | $449.76 | 2026-06-04 | Buy |
| Biosynth | MP59677 | Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | 701976-55-8 | 2mg | $749.6 | 2026-06-04 | Buy |
| Biosynth | MP59677 | Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | 701976-55-8 | 5mg | $1461.7 | 2026-06-04 | Buy |
| Biosynth | MP59677 | Phosphatidyl 1-(D-2,3-dideoxy-myo-inositol) | 701976-55-8 | 10mg | $2623.6 | 2026-06-04 | Buy |
| Usbiological | S1010-74A | SH-6 | 701976-55-8 | 500ug | $462 | 2021-12-16 | Buy |
SH-6 Chemical Properties,Uses,Production
Uses
A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.
Biological Activity
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes
SH-6 Preparation Products And Raw materials
Raw materials
Preparation Products
SH-6 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10778 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29717 | 58 |
| Vicbio Biotechnology Co., Ltd. | 13621190864 13691409741 | info@vicbio.com | China | 13136 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6376 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | -- | sales@biosynth.com | China | 6032 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6575 | 58 |
| Carbosynth | -- | sales@carbosynth.com | United Kingdom | 6967 | 58 |
| Nanjing Meisi Biotechnology Co., Ltd. | -- | CHINA | 1024 | 58 |
