Sappanone A
- CAS No.
- 102067-84-5
- Chemical Name:
- Sappanone A
- Synonyms
- Sappanone A;3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one;(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one;3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
- CBNumber:
- CB63037515
- Molecular Formula:
- C16H12O5
- Molecular Weight:
- 284.26
- MDL Number:
- MFCD21333231
- MOL File:
- 102067-84-5.mol
| Boiling point | 605.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.521±0.06 g/cm3(Predicted) |
| solubility | DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.25 mg/ml |
| form | A solid |
| pka | 7.20±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C16H12O5/c17-11-2-3-12-15(7-11)21-8-10(16(12)20)5-9-1-4-13(18)14(19)6-9/h1-7,17-19H,8H2 |
| InChIKey | KVYZXXBTJHJISR-UHFFFAOYSA-N |
| SMILES | C1OC2=CC(O)=CC=C2C(=O)C1=CC1=CC=C(O)C(O)=C1 |
| FDA UNII | 659E9Z3J5X |
Sappanone A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23205 | Sappanone A ≥98% | 102067-84-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23205 | Sappanone A ≥98% | 102067-84-5 | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 23205 | Sappanone A ≥98% | 102067-84-5 | 10mg | $252 | 2024-03-01 | Buy |
| Cayman Chemical | 23205 | Sappanone A ≥98% | 102067-84-5 | 25mg | $550 | 2024-03-01 | Buy |
| Cayman Chemical | 23205 | SappanoneA ≥98% | 102067-84-5 | 50mg | $792 | 2021-12-16 | Buy |
Sappanone A Chemical Properties,Uses,Production
Description
Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.
Uses
Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.
Biological Activity
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.
References
[1] LI-GEN LIN. Naturally Occurring Homoisoflavonoids Function as Potent Protein Tyrosine Kinase Inhibitors by c-Src-Based High-Throughput Screening[J]. Journal of Medicinal Chemistry, 2008, 51 15: 4419-4429. DOI: 10.1021/jm701501x
[2] HYUNG JAE JEONG. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition.[J]. Biological & pharmaceutical bulletin, 2012, 35 5: 786-790. DOI: 10.1248/bpb.35.786
[3] BISWANATH DAS. Isolation, synthesis, and bioactivity of homoisoflavonoids from Caesalpinia pulcherrima.[J]. Chemical & pharmaceutical bulletin, 2009, 57 10: 1139-1141. DOI: 10.1248/cpb.57.1139
[4] SUHYUN LEE . Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB[J]. International immunopharmacology, 2015, 28 1: Pages 328-336. DOI: 10.1016/j.intimp.2015.06.015
[5] XUESHIBOJIE LIU Tiejun W Duo Yu. Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma.[J]. International Archives of Allergy and Immunology, 2016, 170 3: 180-186. DOI: 10.1159/000448331
Sappanone A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 12931 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
| Chengdu Senior Pharma Technology Co.Ltd. | +86-0838-2319818 +86-15982001943 | seniorpharma@163.com | China | 435 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
View Lastest Price from Sappanone A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-30 | Sappanone A
102067-84-5
|
US $55.00-197.00 / mg | 99.18% | 10g | TargetMol Chemicals Inc. |
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- Sappanone A
102067-84-5
- US $55.00-197.00 / mg
- 99.18%
- TargetMol Chemicals Inc.
