UNC3230
- CAS No.
- 1031602-63-7
- Chemical Name:
- UNC3230
- Synonyms
- UNC3230;UNC3230, 10 mM in DMSO;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
- CBNumber:
- CB63067589
- Molecular Formula:
- C17H20N4O2S
- Molecular Weight:
- 344.43
- MDL Number:
- MFCD15031190
- MOL File:
- 1031602-63-7.mol
| Product description | Number | Pack Size | Price |
| UNC3230 ≥98% (HPLC) | SML4055 | 1 unit | $94.05 |
| UNC3230 ≥95% | 16401 | 1mg | $48 |
| UNC3230 ≥95% | 16401 | 5mg | $117 |
| UNC3230 ≥95% | 16401 | 10mg | $210 |
| UNC3230 ≥95% | 16401 | 50mg | $807 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
UNC3230 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML4055 | UNC3230 ≥98% (HPLC) | 1031602-63-7 | 1 unit | $94.05 | 2025-07-31 | Buy |
| Cayman Chemical | 16401 | UNC3230 ≥95% | 1031602-63-7 | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 16401 | UNC3230 ≥95% | 1031602-63-7 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 16401 | UNC3230 ≥95% | 1031602-63-7 | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 16401 | UNC3230 ≥95% | 1031602-63-7 | 50mg | $807 | 2024-03-01 | Buy |
UNC3230 Chemical Properties,Uses,Production
Description
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.
Uses
UNC 3230 is a potent inhibitor of PIP5K1C.
in vivo
UNC3230 (2 nmol) significantly increases noxious heat-evoked paw withdrawal latency for two hours after intrathecal injection in wild-type mice, indicating an antinociceptive effect[1].
UNC3230 (2 nmol; intrathecal injection) is administered then one hour later co-injected 1 nmol LPA with UNC3230 (2 nmol, intrathecal injection). UNC3230 significantly blunts thermal hyperalgesia and mechanical allodynia compared to vehicle[1].
UNC3230 (2 nmol; intrathecal injection) significantly blunts thermal hyperalgesia and mechanical allodynia in the complete Freund’s adjuvant (CFA)-inflamed hindpaw (relative to vehicle control) but does not affect thermal or mechanical sensitivity in the control (non-inflamed) hindpaw over a multiday time course[1].
storage
Store at +4°C
References
[1] BRITTANY D WRIGHT. The lipid kinase PIP5K1C regulates pain signaling and sensitization.[J]. Neuron, 2014: 836-847. DOI: 10.1016/j.neuron.2014.04.006
UNC3230 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618791163155 | 18791163155@163.com | China | 3397 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4757 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
