3-Hydroxymethylpyrrolidine
- CAS No.
- 5082-74-6
- Chemical Name:
- 3-Hydroxymethylpyrrolidine
- Synonyms
- Albb-005836;AKOS BB-9752;DL-beta-Prolinol;DL-^b-Prolinol, 97+%;3-Pyrrolidinemethanol;3-pyrrolidinylmethanol;ASINEX-REAG BAS 10144565;PYRROLIDIN-3-YL-METHANOL;PYRROLIDINE-3-YL METHANOL;(RS)-3-Pyrrolidinemethanol
- CBNumber:
- CB6312622
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD07773080
- MOL File:
- 5082-74-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pyrrolidin-3-ylmethanol min. 95.0 % | P2000 | 200MG | $39 |
| Pyrrolidin-3-ylmethanol min. 95.0 % | P2000 | 1G | $134 |
| 3-Pyrrolidinemethanol 95% | OR309156 | 1g | $35 |
| 3-Pyrrolidinemethanol 95% | OR309156 | 5g | $160 |
| 3-Pyrrolidinemethanol 97% | AS31306-A | 1g | $35 |
| More product size | |||
| Boiling point | 165-171℃ |
|---|---|
| Density | 0.979 |
| Flash point | 86℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| pka | 14.93±0.10(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| Water Solubility | Slightly soluble in water |
| Sensitive | Hygroscopic |
| BRN | 1420904 |
| InChI | InChI=1S/C5H11NO/c7-4-5-1-2-6-3-5/h5-7H,1-4H2 |
| InChIKey | QOTUIIJRVXKSJU-UHFFFAOYSA-N |
| SMILES | N1CCC(CO)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
3-Hydroxymethylpyrrolidine price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2000 | Pyrrolidin-3-ylmethanol min. 95.0 % | 5082-74-6 | 200MG | $39 | 2026-04-30 | Buy |
| TCI Chemical | P2000 | Pyrrolidin-3-ylmethanol min. 95.0 % | 5082-74-6 | 1G | $134 | 2026-04-30 | Buy |
| Apolloscientific | OR309156 | 3-Pyrrolidinemethanol 95% | 5082-74-6 | 1g | $35 | 2026-06-04 | Buy |
| Apolloscientific | OR309156 | 3-Pyrrolidinemethanol 95% | 5082-74-6 | 5g | $160 | 2026-06-04 | Buy |
| Activate Scientific | AS31306-A | 3-Pyrrolidinemethanol 97% | 5082-74-6 | 1g | $35 | 2026-06-04 | Buy |
3-Hydroxymethylpyrrolidine Chemical Properties,Uses,Production
Uses
3-Pyrrolidinemethanoln is a useful reagent in preparation of orally active (heterocyclic aminomethyl)pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Synthesis
35309-35-4
85310-69-6
The general procedure for the synthesis of 3-pyrrolidinemethanol from methyl 5-oxopyrrolidine-3-carboxylate is as follows: 2 kg of methyl 5-oxo-3-pyrrolidinecarboxylate is dissolved in 20 liters of tetrahydrofuran, and 1.9 kg of sodium borohydride is added in batches at room temperature. Subsequently, 3.9 kg of boron trifluoride ether solution was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 10 minutes and then heated to reflux for about 4 hours. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate. The organic phases were combined and concentrated to give a light yellow oily liquid. This oily liquid was dissolved in ethanol, 500 g of sodium borohydride was added and heated to reflux for 2 hours. At the end of the reaction, the reaction was again quenched with water and extracted with ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate and saturated brine, and finally the organic phase was concentrated to give 1.2 kg of 3-pyrrolidinemethanol in 86% yield.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0032; 0034; 0039; 0042; 0044
3-Hydroxymethylpyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 296 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 3-Hydroxymethylpyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 3-Hydroxymethylpyrrolidine
5082-74-6
|
$100.00-2500.00 | 1KG | 98% | 5MT per month | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2021-07-02 | Pyrrolidin-3-ylmethanol
5082-74-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-10 | 3-Hydroxymethylpyrrolidine
5082-74-6
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-Hydroxymethylpyrrolidine
5082-74-6
- $100.00-2500.00
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- Pyrrolidin-3-ylmethanol
5082-74-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Hydroxymethylpyrrolidine
5082-74-6
- $7.00
- 99%
- Career Henan Chemical Co
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