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2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER structure

CAS No.: 344-72-9

Chemical Name:: 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Synonyms: ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE;NSC 4465;AKOS B029496;BUTTPARK 11\03-53;TIMTEC-BB SBB005528;Ethyl 2-amino-4-(trifluoromethyl);Ethyl-2-amino-4-trifluoromethylthiazolecarboxylate;2-AMINO-4-(TRIFLUOROMETHYL)-5-(CARBETHOXY)THIAZOLE;ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXY;ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAXOLE-5-CARBOXYLATE

CBNumber:: CB6313861

Molecular Formula:: C7H7F3N2O2S

Molecular Weight:: 240.2

MDL Number:: MFCD00153147

MOL File:: 344-72-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:59:14

Product description	Number	Pack Size	Price
Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97%	PC3161M	1g	$21
Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97%	PC3161M	1g	$21
Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	25676	1G	$30.35
Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	25676	5G	$120.58
Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	25676	25G	$482.62
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2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Properties

Melting point	170 °C
Boiling point	81.4°C (rough estimate)
Density	1.479
storage temp.	2-8°C, protect from light
pka	0.08±0.10(Predicted)
Appearance	White to light yellow Solid
CAS DataBase Reference	344-72-9(CAS DataBase Reference)
FDA UNII	9WH6LMH3RA
EPA Substance Registry System	5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester (344-72-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P261-P280-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39
TSCA	TSCA listed
HazardClass	IRRITANT
HS Code	2934100090
Toxicity	LDLo ivn-mus: 75 mg/kg CBCCT* 6,142,54

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC3161M	Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97%	344-72-9	1g	$21	2026-06-04	Buy
Apolloscientific	PC3161M	Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97%	344-72-9	1g	$21	2026-06-04	Buy
Chem-Impex	25676	Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	344-72-9	1G	$30.35	2026-05-19	Buy
Chem-Impex	25676	Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	344-72-9	5G	$120.58	2026-05-19	Buy
Chem-Impex	25676	Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate ≥98%(HPLC)	344-72-9	25G	$482.62	2026-05-19	Buy

Product number	Packaging	Price	Buy
PC3161M	1g	$21	Buy
PC3161M	1g	$21	Buy
25676	1G	$30.35	Buy
25676	5G	$120.58	Buy
25676	25G	$482.62	Buy

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 907, 1991 DOI: 10.1002/jhet.5570280412

Safety Profile

Poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

Ethyl 2-chloro-4,4,4-trifluoroacetoacetate

363-58-6

17356-08-0

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

344-72-9

Step 1: Synthesis of ethyl 2-amino-4-trifluoromethylthiazole-5-carboxylate (A-31) To an ethanol (200 mL) suspension of thiourea (3.3 g, 22.88 mmol) was added ethyl 2-chloro-4,4,4-trifluoroacetoacetate (5 g, 22.88 mmol), and the resulting reaction mixture was heated at 80 °C for 24 hours. Subsequently, the reaction mixture was cooled to room temperature and concentrated under vacuum. The crude product was purified by column chromatography to afford ethyl 2-amino-4-trifluoromethylthiazole-5-carboxylate (A-31) as a colorless oil (5.98 g, 85% yield). 1H NMR (500 MHz, CDCl3) δ 4.32 (q, 2H, J = 7.0 Hz), 3.56 (m, 4H), 1.70 (m, 6H), 1.36 (t, 3H, J = 7.0 Hz); LCMS (ESI) [M + 1]+ 309.3.

References

[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 6, p. 3395 - 3402
[2] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 2, p. 1625 - 1629
[3] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 169
[4] Tetrahedron Letters, 2005, vol. 46, # 13, p. 2251 - 2252
[5] Patent: US2004/138268, 2004, A1. Location in patent: Page/Page column 15

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER synthesis

Synthesis of 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER from Ethyl 2-chloro-4,4,4-trifluoroacetoacetate

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

5H-1,2,3-Dithiazol-5-one, 4-chloro- (Z)-3-Amino-4,4,4-trifluorocrotonic acid ethyl ester Ethyl 2-chloro-4,4,4-trifluoroacetoacetate ETHYL TRIFLUOROACETYLBROMOACETATE Carbamimidothioic acid

Ethyl 4,4,4-trifluoroacetoacetate

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Preparation Products

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16512	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58

View Lastest Price from 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-17	ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 344-72-9	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2020-02-01	2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 344-72-9	$3.00	1KG	98%	100KG	Career Henan Chemical Co

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
344-72-9
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
344-72-9
$3.00
98%
Career Henan Chemical Co

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Spectrum

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(344-72-9)¹HNMR

344-72-9(2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER)Related Search:

2-ALLYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-pyrrolidin-1-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 2-CYCLOPENTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-C&

2-CYCLOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-MORPHOLINO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 2-PHENYLAMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER AKOS B029504 AKOS B029497

AKOS B029553 2-ISOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER AKOS B029500 AKOS B029499 2-SEC-BUTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-piperidin-1-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ETHYL 2-DIMETHYLAMINO-4-TRIFLUOROMETHYL-5-THIAZOLECARBOXYLATE AKOS B029498

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Ethyl-2-amino-4-trifluoromethylthiazolecarboxylate 5-Thiazolecarboxylicacid, 2-aMino-4-(trifluoroMethyl)-, ethyl ester NSC 4465 Ethyl 2-amino-4-(trifluoromethyl) JR-6609, Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate, 97% 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylicacidethylester 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylicaciethylester BUTTPARK 11\03-53 ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXYLATE ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAXOLE-5-CARBOXYLATE AKOS B029496 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(TRIFLUOROMETHYL)-5-(CARBETHOXY)THIAZOLE TIMTEC-BB SBB005528 Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate 97% Ethyl2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate97% ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXY Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97% 6-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylic acid methyl ester -AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester (6CI, 8CI, 9CI, ACI) 2-amino-4-(trifluoromethyl)-5-Thiazolecarboxylic acid ethyl ester (6CI 8CI 9CI ACI) Ethyl 2-amino-4-(trifluoromethyl)-thiazol-5-carboxylate ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 344-72-9 C7H7F3N2O2S Amines blocks Carboxes FluoroCompounds Oxazoles