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ChemicalBook >> CAS DataBase List >>5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Structure
5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine structure
CAS No.
1610964-64-1
Chemical Name:
5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine
Synonyms
Unesbulin;PTC596;Unesbulin (PTC596);Unesbulin (PTC596) ，S8820;Unesbulin free base PTC596;Unesbulin (Synonyms: PTC596);5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine;5-Fluoro-2-(6-fluoro-2-methyl-1H-benzoimidazol-1-yl)-N-(4-trifluoromethylphenyl)-pyrimidine-4,6-diamine;4,6-Pyrimidinediamine, 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N4-[4-(trifluoromethyl)phenyl]-;5-Fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine
CBNumber:
CB63147173
Molecular Formula:
C19H13F5N6
Molecular Weight:
420.34
MDL Number:
MFCD30489439
MOL File:
1610964-64-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
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5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Properties

Boiling point 583.9±60.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);71.4(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);71.4(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);11.9(Max Conc. mM)
form A crystalline solid
pka 2.65±0.10(Predicted)
color White to off-white
FDA UNII Z4HZ70S62Q

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 33529 PTC-596 ≥98% 1610964-64-1 1mg $87 2026-04-30 Buy
Cayman Chemical 33529 PTC-596 ≥98% 1610964-64-1 5mg $348 2026-04-30 Buy
Cayman Chemical 33529 PTC-596 ≥98% 1610964-64-1 10mg $566 2026-04-30 Buy
Cayman Chemical 33529 PTC-596 ≥98% 1610964-64-1 25mg $978 2026-04-30 Buy
Biosynth KPC96464 PTC596 1610964-64-1 25mg $801.75 2026-06-04 Buy
Product number Packaging Price Buy
33529 1mg $87 Buy
33529 5mg $348 Buy
33529 10mg $566 Buy
33529 25mg $978 Buy
KPC96464 25mg $801.75 Buy

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Chemical Properties, Uses, Production

Uses

Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity[1][2].

in vivo

Unesbulin (PTC596; 5 mg/kg; oral gavage; every 3 days for 13 days) significantly prolongs mouse survival[1].
Unesbulin (20 mg/kg; oral gavage; once a week for 15 days) causes tumor volume significantly smaller than that of control SCID mice with K562 cells[1].
Unesbulin (10 or 12.5 mg/kg; oral gavage; twice a week until death) causes the survival significantly longer than the vehicle-treated group in NOD-SCID mice with HL-60 cells[1].

Animal Model:NOD-SCID/IL2Rγ-KO (NSG) mice with MOLM-13 cells[1]
Dosage:5mg/kg
Administration:Oral gavage; every 3 days for 13 days
Result:Significantly prolonged mouse survival compared with the vehicle-treated mice in a dose-dependent manner.

References

[1] Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7(2):e527. DOI:10.1038/bcj.2017.8
[2] BMI1 inhibitor PTC596

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Suppliers

Global Suppliers ( 55)
Supplier Tel Email Country ProdList Advantage
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1359 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1965 58
Supplier Advantage
Dalian Meilun Biotech Co., Ltd. 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Moss Medicine Technology Co., Ltd. 58

View Latest Price from 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Unesbulin pictures 2026-06-02 Unesbulin
1610964-64-1
 $89.00-313.00 98.71% 10g TargetMol Chemicals Inc.
Unesbulin pictures 2026-06-02 Unesbulin
1610964-64-1
 $89.00-313.00 98.71% 10g TargetMol Chemicals Inc.
  • Unesbulin pictures
  • Unesbulin
    1610964-64-1
  • $89.00-313.00
  • 98.71%
  • TargetMol Chemicals Inc.
  • Unesbulin pictures
  • Unesbulin
    1610964-64-1
  • $89.00-313.00
  • 98.71%
  • TargetMol Chemicals Inc.

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine Spectrum

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine(1610964-64-1)1HNMR

1610964-64-1 (5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine) Related Search:

5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine PTC-209 (PTC209 S-72 Estramustine sodium phosphate PTC-028
NA

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5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine PTC596 5-Fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine 4,6-Pyrimidinediamine, 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N4-[4-(trifluoromethyl)phenyl]- 5-Fluoro-2-(6-fluoro-2-methyl-1H-benzoimidazol-1-yl)-N-(4-trifluoromethylphenyl)-pyrimidine-4,6-diamine Unesbulin (Synonyms: PTC596) integration,p53,Moloney,murine,leukemic,orally,virus,G2/M,BMI-1,Inhibitor,APC/CCDC20,Apoptosis,Unesbulin,inhibit,PTC 596,leukemia,PTC-596,AML Unesbulin (PTC596) Unesbulin (PTC596) ，S8820 Unesbulin free base PTC596 Unesbulin 5-Fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N4-[4-(trifluoromethyl)phenyl]-4,6-pyrimidinediamine (ACI) 1610964-64-1 C19H13F5N6