Doxylamine
- CAS No.
- 469-21-6
- Chemical Name:
- Doxylamine
- Synonyms
- oxylamine;Dosilamin;NCI C60684;Doxylamine;(±)-Doxylamine;DOXYLAMINE USP/EP/BP;Doxylamine Hydrogen inate;2-dimethylaminoethoxyphenylmethyl-2-picoline;alpha-Dimethylaminoethoxyphenylmethyl-2-picoline;2-[a-(2-dimethylaminoethoxy)-a-methylbenzyl]pyridine
- CBNumber:
- CB6316736
- Molecular Formula:
- C17H22N2O
- Molecular Weight:
- 270.37
- MDL Number:
- MFCD00599469
- MOL File:
- 469-21-6.mol
| Melting point | 25°C |
|---|---|
| Boiling point | bp0.5 137-141° |
| Density | 1.0023 (rough estimate) |
| refractive index | 1.5486 (estimate) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | pKa 9.20(H2O t = 25 c = 0.002–0.01) (Uncertain);4.4 (Uncertain);9.2 (Uncertain) |
| color | Colourless |
| Stability | Temperature Sensitive |
| InChI | InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3 |
| InChIKey | HCFDWZZGGLSKEP-UHFFFAOYSA-N |
| SMILES | C(N(C)C)COC(C1=CC=CC=C1)(C1=NC=CC=C1)C |
| FDA UNII | 95QB77JKPL |
| ATC code | R06AA09,R06AA59 |
| EPA Substance Registry System | Doxylamine (469-21-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Hazardous Substances Data | 469-21-6(Hazardous Substances Data) |
| Toxicity | An antihistamine that formerly was used in pregnant women for antihistaminic and sedative properties. Although it has excellent sedative properties, it has been implicated in teratogenesis and in causing neurobehavioral toxicity and is therefore no longer used |
| REACH Registrations | Active |
Doxylamine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D562005-500MG | (±)-Doxylamine >95%(HPLC) | 469-21-6 | 500mg | $1054 | 2026-06-03 | Buy |
| TRC | TRC-D562005-250MG | (±)-Doxylamine >95%(HPLC) | 469-21-6 | 250mg | $557 | 2026-06-03 | Buy |
| TRC | TRC-D562005-1G | (±)-Doxylamine >95%(HPLC) | 469-21-6 | 1g | $1762 | 2026-06-03 | Buy |
| ChemScene | CS-0013585 | Doxylamine | 469-21-6 | 50mg | $190 | 2026-06-04 | Buy |
| ChemScene | CS-0013585 | Doxylamine | 469-21-6 | 100mg | $303 | 2026-06-04 | Buy |
Doxylamine Chemical Properties,Uses,Production
Uses
Antihistaminic.
Uses
(±)-Doxylamine is an intermediate in the synthesis of Doxylamine N, N’-Dioxide (D562025), which is an impurity of Doxylamine (succinate salt, D562000), which is an H1 Histamine receptor antagonist.
Definition
ChEBI: Doxylamine is a member of pyridines and a tertiary amine. It has a role as a histamine antagonist, a cholinergic antagonist, a sedative, an antiemetic, a H1-receptor antagonist, an anti-allergic agent and an antitussive.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
Clear colorless liquid.
Reactivity Profile
DOXYLAMINE is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides
Synthesis
Doxylamine is synthesized from phenyl-2- pyridinylmethyl carbinol and dimethylaminoethyl chloride in the presence of NaNH2 in xylene . It exhibits pronounced sedative effects. Therefore, doxylamine is mainly used as a sedative, a sleeping aid.
Doxylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chenguang Tianrun Pharma Co., Ltd. | 0310-2816865 15175172220 | hbcgtr@126.com | China | 13 | 58 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Conier Chem & Pharma Limited | 13368167990 | sales@conier.com | China | 187 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd. | 029-88380327 17691182729 | 1053@dideu.com | China | 2001 | 58 |
View Lastest Price from Doxylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | DOXYLAMINE
469-21-6
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2024-01-18 | doxylamine
469-21-6
|
$88.00 | 1KG | 99% | 330T | Xiamen Wonderful Bio Technology Co., Ltd. | |
 |
2023-08-31 | doxylamine
469-21-6
|
$100.00 | 1bag | 99 | 5000 | Hebei Fengqiang Trading Co., LTD |
-
- DOXYLAMINE
469-21-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- doxylamine
469-21-6
- $88.00
- 99%
- Xiamen Wonderful Bio Technology Co., Ltd.
-
- doxylamine
469-21-6
- $100.00
- 99
- Hebei Fengqiang Trading Co., LTD
