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ChemicalBook >> CAS DataBase List >>Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) Structure
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) structure
CAS No.
130466-38-5
Chemical Name:
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
Synonyms
Vatinoxan hydrochloride;MK-467 hydrochloride;L-659066 hydrochloride;N-[2-[(2R,12bS)-2'-Oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]methanesulfonamide Hydrochloride;Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
CBNumber:
CB63186264
Molecular Formula:
C20H27ClN4O4S
Molecular Weight:
454.97
MDL Number:
MFCD08056257
MOL File:
130466-38-5.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) Properties

storage temp. Store at -20°C
form Solid
color White to off-white
Water Solubility Water : ≥ 133 mg/mL (292.33 mM)
FDA UNII 66932R910R

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FFA46638 Vatinoxan hydrochloride 130466-38-5 5mg $1752.3 2026-06-04 Buy
Biosynth FFA46638 Vatinoxan hydrochloride 130466-38-5 10mg $2790.7 2026-06-04 Buy
Biosynth FFA46638 Vatinoxan hydrochloride 130466-38-5 25mg $5711.25 2026-06-04 Buy
Biosynth FFA46638 Vatinoxan hydrochloride 130466-38-5 50mg $9086 2026-06-04 Buy
ChemScene CS-0018087 Vatinoxan hydrochloride 99.79% 130466-38-5 5mg $921 2026-06-04 Buy
Product number Packaging Price Buy
FFA46638 5mg $1752.3 Buy
FFA46638 10mg $2790.7 Buy
FFA46638 25mg $5711.25 Buy
FFA46638 50mg $9086 Buy
CS-0018087 5mg $921 Buy

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) Chemical Properties, Uses, Production

Uses

Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

in vivo

Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine[2].

IC 50

α adrenergic receptor

References

[1] Honkavaara JM, et al. The effects of increasing doses of MK-467, a peripheral alpha(2)-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. J Vet Pharmacol Ther. 2011 Aug;34(4):332-7. DOI:10.1111/j.1365-2885.2010.01242.x
[2] Honkavaara J, et al. The effect of MK-467, a peripheral α2-adrenoceptor antagonist, on dexmedetomidine-inducedsedation and bradycardia after intravenous administration in conscious cats. Vet Anaesth Analg. 2017 Feb 22. pii: S1467-2987(16)31387-3. DOI:10.1111/vaa.12385

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) Suppliers

Global Suppliers ( 19)
Supplier Tel Email Country ProdList Advantage
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3917 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Tianjin Keluo Pharmaceutical Technology Co. LTD 022-23869539 18920052327 281258989@qq.com China 65 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
TaiChem Taizhou Limited 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
BOC Sciences 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Tianjin Keluo Pharmaceutical Technology Co. LTD 58
cjbscvictory 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vatinoxan hydrochloride pictures 2026-07-15 Vatinoxan hydrochloride
130466-38-5
 $3420.00-5600.00 10g TargetMol Chemicals Inc.
Vatinoxan hydrochloride pictures 2026-07-15 Vatinoxan hydrochloride
130466-38-5
 $3420.00-5600.00 10g TargetMol Chemicals Inc.
Vatinoxan hydrochloride pictures 2025-05-27 Vatinoxan hydrochloride
130466-38-5
 $3700.00-9540.00 10g TargetMol Chemicals Inc.

130466-38-5 (Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)) Related Search:

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Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1) L-659066 hydrochloride MK-467 hydrochloride N-[2-[(2R,12bS)-2'-Oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]methanesulfonamide Hydrochloride Vatinoxan hydrochloride 130466-38-5 C20H26N4O4SClH API