5-Fluoroorotic acid
- CAS No.
- 703-95-7
- Chemical Name:
- 5-Fluoroorotic acid
- Synonyms
- foa;5-FOA;fo;Fluoxydin;5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid;5' FOA;ro2-9945;nsc31712;ent-26398;WR 152520
- CBNumber:
- CB6325772
- Molecular Formula:
- C5H3FN2O4
- Molecular Weight:
- 174.09
- MDL Number:
- MFCD00042526
- MOL File:
- 703-95-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 278 °C (dec.)(lit.) |
|---|---|
| Boiling point | 143°C (rough estimate) |
| Density | 1.6154 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
| pka | 2.04±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| Merck | 14,4176 |
| InChI | InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12) |
| InChIKey | LODRRYMGPWQCTR-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(=O)C(F)=C(C(O)=O)N1 |
| CAS DataBase Reference | 703-95-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7IA9OUC93E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312+P330-P501-P261-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36-36/37/39-27 |
| WGK Germany | 3 |
| RTECS | UV7800000 |
| F | 10 |
| HazardClass | IRRITANT |
| HS Code | 29335990 |
5-Fluoroorotic acid price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0382 | 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) | 703-95-7 | 1g | $49 | 2025-07-31 | Buy |
| TCI Chemical | F0382 | 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) | 703-95-7 | 100mg | $16 | 2025-07-31 | Buy |
| Biosynth | FF71651 | 5-Fluoroorotic acid potassium salt | 703-95-7 | 0.5g | $150 | 2026-06-04 | Buy |
| Biosynth | FF71651 | 5-Fluoroorotic acid potassium salt | 703-95-7 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FF71651 | 5-Fluoroorotic acid potassium salt | 703-95-7 | 2.5g | $163.17 | 2026-06-04 | Buy |
5-Fluoroorotic acid Chemical Properties, Uses, Production
Chemical Properties
White to Off-White Crystalline Solid
Uses
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
Uses
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
5-Fluoroorotic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Foshan Liyuan Chemical Co., Ltd | 13889923167 13690318880 | 1170464690@qq.com | China | 56 | 58 |
| Weihai Zhaochuan Biotechnology Co., Ltd. | 13863193635 | 53702483@qq.com | China | 401 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44566 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 5-Fluoroorotic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-13 | 5-Fluoroorotic acid
703-95-7
|
$29.00 | 99.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | 5-Fluoroorotic Acid
703-95-7
|
$10.00 | 1KG | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 5-Fluoroorotic acid
703-95-7
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 5-Fluoroorotic acid
703-95-7
- $29.00
- 99.77%
- TargetMol Chemicals Inc.
-
- 5-Fluoroorotic Acid
703-95-7
- $10.00
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 5-Fluoroorotic acid
703-95-7
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
