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5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione structure

CAS No.: 1133819-87-0

Chemical Name:: 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione

Synonyms: MSDC 0602;Azemiglitazone;Azemiglitazone (MSDC-0602);Azemiglitazone, 10 mM in DMSO;MSDC-0602; MSDC0602; MSDC 0602;Azemiglitazone (MSDC-0602) ，S7454;5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione;5-[[4-[2-(3-Methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione;Mitochondrial Metabolism,Azemiglitazone,inhibit,MSDC-0602,Inhibitor,MSDC0602;2,4-Thiazolidinedione, 5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-

CBNumber:: CB63303267

Molecular Formula:: C19H17NO5S

Molecular Weight:: 371.41

MDL Number:: MFCD28502493

MOL File:: 1133819-87-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:13

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5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione Properties

Melting point	>176°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
color	Pale Yellow to Light Yellow
FDA UNII	81MXZ6QOBM

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27829	MSDC-0602 ≥95%	1133819-87-0	10mg	$96	2026-04-30	Buy
Cayman Chemical	27829	MSDC-0602 ≥95%	1133819-87-0	25mg	$213	2026-04-30	Buy
Cayman Chemical	27829	MSDC-0602 ≥95%	1133819-87-0	50mg	$400	2026-04-30	Buy
Cayman Chemical	27829	MSDC-0602 ≥95%	1133819-87-0	100mg	$702	2026-04-30	Buy
TRC	TRC-M755420-50MG	MSDC 0602	1133819-87-0	50mg	$402	2026-06-03	Buy

Product number	Packaging	Price	Buy
27829	10mg	$96	Buy
27829	25mg	$213	Buy
27829	50mg	$400	Buy
27829	100mg	$702	Buy
TRC-M755420-50MG	50mg	$402	Buy

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione Chemical Properties, Uses, Production

Uses

MSDC 0602, an analogue ofthiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.

in vivo

Azemiglitazone (2-5 μM in blood, p.o for 2-4 weeks) improves insulin sensitivity in striated muscle, adipose tissue, and liver of DIO C57BL/6 mice^[6].
Azemiglitazone (2-5 μM in blood, p.o for 2-4 weeks) improves mitochondrial respiratory rate in DIO C57BL/6 mice^[6]. Azemiglitazone reduces NASH caused liver injury, prevents (2-5 μM in blood, p.o. for 12 weeks) and reverses (2-5 μM in blood, p.o. for 3 weeks) stellate cells activation and fibrosis in HTF-C diet feeding C57BL6/J mice^[4].
Azemiglitazone (2-5 μM in blood, p.o.) causes weight loss and suppresses stellate cell activation with or without MPC function in HTF-C diet feeding LS-Mpc^2-/-C57BL6/J mice^[4].

Animal Model:	HTF-C diet feeding C57BL6/J mice ^[4]
Dosage:	331 ppm MSDC-0602 potassium salt (2-5 μM Azemiglitazone in blood)
Administration:	oral administration for 12 weeks (after 4 weeks of HTF-C diet) or 3 weeks (16 weeks after HTF-C diet)
Result:	Induced weight loss, decreased concentrations of plasma ALT and AST and stellate cell activation.

Animal Model:	HTF-C diet feeding LS-Mpc^2-/-C57BL6/J mice ^[4]
Dosage:	331 ppm MSDC-0602 potassium salt (2-5 μM Azemiglitazone in blood)
Administration:	oral administration for 12 weeks (after 4 weeks of HTF-C diet)
Result:	Induced weight loss, suppressed stellate cell activation.

Animal Model:	diet induced obesity C57BL/6 mice^[6]
Dosage:	300 ppm MSDC-0602 (2-5 μM Azemiglitazone in blood)
Administration:	oral administration for 2-4 weeks
Result:	Reduced insulin concentration in plasma, increased glucose infusion rate and glucose uptake into gastrocnemius, adipose tissue, and heart. Improved mitochondrial oxygen consumption.

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione synthesis

Synthesis of 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione Preparation Products And Raw materials

Raw materials

1-(Epoxyethyl)-3-methoxybenzene 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]- 3-Vinylanisole 97 3'-Methoxyphenacyl bromide

4-Hydroxybenzaldehyde

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Preparation Products

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione Suppliers

Global Suppliers ( 65)

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7717	56
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9729	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai Yu Ben Biotechnology Co., Ltd.	021-61350663 15502154572	1639466865@qq.com	China	498	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	13370351217 kungfu1217@1	kungfu1217@163.com	China	7991	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58

Supplier	Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Shanghai JiYi Biotechnology Co. Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
Amadis Chemical Company Limited	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
Yujinpharma(Tianjin) Technology Co.,Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
InvivoChem	58

View Latest Price from 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Azemiglitazone 1133819-87-0	$52.00-148.00		98.29%	10g	TargetMol Chemicals Inc.

Azemiglitazone
1133819-87-0
$52.00-148.00
98.29%
TargetMol Chemicals Inc.

5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione Spectrum

5-(4-(2-(3-METHOXYPHENYL)-2-OXOETHOXY)BENZYL)THIAZOLIDINE-2,4-DIONE(1133819-87-0)¹HNMR

1133819-87-0 (5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione) Related Search:

5-[(3-phenoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione 5-[(2,6-dimethoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione (5S)-5-[(4-Hydroxyphenyl)methyl]-2,4-thiazolidinedione Acetaldehyde, 2-[4-[(2,4-dioxo-5-thiazolidinyl)methyl]phenoxy]- MSDC-0602K

5-(4-Hydroxybenzyl)-2,4-thiazolidinedione

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5-[[4-[2-(3-Methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione MSDC-0602; MSDC0602; MSDC 0602 2,4-Thiazolidinedione, 5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]- Mitochondrial Metabolism,Azemiglitazone,inhibit,MSDC-0602,Inhibitor,MSDC0602 Azemiglitazone (MSDC-0602) Azemiglitazone, 10 mM in DMSO Azemiglitazone (MSDC-0602) ，S7454 Azemiglitazone MSDC 0602 5-(4-(2-(3-Methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione 1133819-87-0