GSK-626616
- CAS No.
- 1025821-33-3
- Chemical Name:
- GSK-626616
- Synonyms
- GSK-626616;GSK 626616 - Bio-X ?;GSK-626616, 10 mM in DMSO;(Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- CBNumber:
- CB63303333
- Molecular Formula:
- C18H10Cl2N4OS
- Molecular Weight:
- 401.27
- MDL Number:
- MFCD31689261
- MOL File:
- 1025821-33-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 281 - 282oC |
|---|---|
| Boiling point | 574.8±60.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| pka | -0.94±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
| InChI | 1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9- |
| InChIKey | RJPNRXFBYZVRIB-DHDCSXOGSA-N |
| SMILES | ClC(C=CC=C1Cl)=C1NC2=NC(/C(S2)=C/C3=CC4=C(N=CC=N4)C=C3)=O |
| FDA UNII | OKY0RM282V |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H302-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
GSK-626616 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3355 | GSK626616 ≥98% (HPLC) | 1025821-33-3 | 5MG | $95.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3355 | GSK626616 ≥98% (HPLC) | 1025821-33-3 | 25MG | $386 | 2026-04-30 | Buy |
| Cayman Chemical | 34621 | GSK626616 ≥98% | 1025821-33-3 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 34621 | GSK626616 ≥98% | 1025821-33-3 | 5mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 34621 | GSK626616 ≥98% | 1025821-33-3 | 10mg | $268 | 2026-04-30 | Buy |
GSK-626616 Chemical Properties, Uses, Production
Uses
GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
Biological Activity
GSK626616 is an orally available, ATP-competitive, potent and selective dual-specificity tyrosine phosphorylation-regulated kinase DYRK inhibitor (DYRK3 IC50 = 0.7 nM; similar potency against DYRK1A and DYRK2) with 20-fold selectivity over the closed related casein kinase 2. GSK626616 enhances Epo-stimulated increase of human marrow erythroid colony formation units (CFU-E), without affecting megakaryocyte colony growth or CFU-GM formation. GSK626616 enhances the percentage and number of Ter119+/CD71+ erythroid progenitors derived from kit+ mouse marrow in the presence of SCF and Epo in cultures, and exhibits therapeutic efficacy in a murine anemia model in vivo (0.03 mg/kg/d i.p.)
IC 50
DYRK1; DYRK2; DYRK3
storage
Store at +4°C
GSK-626616 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-626616 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
View Latest Price from GSK-626616 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | GSK-626616
1025821-33-3
|
$44.00-139.00 | 99.48% | 10g | TargetMol Chemicals Inc. |
-
- GSK-626616
1025821-33-3
- $44.00-139.00
- 99.48%
- TargetMol Chemicals Inc.
