Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>NVS-PAK1-1

NVS-PAK1-1

NVS-PAK1-1 Structure
NVS-PAK1-1 structure
CAS No.
1783816-74-9
Chemical Name:
NVS-PAK1-1
Synonyms
NVS-PAK1-1;NVS-PAK1-1 ，S8264;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1, 10 mM in DMSO;NVS-PAK1-1, PAK1 inhibitor;NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
CBNumber:
CB63333615
Molecular Formula:
C23H25ClF3N5O
Molecular Weight:
479.93
MDL Number:
MFCD30723183
MOL File:
1783816-74-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

NVS-PAK1-1 Properties

Boiling point 697.8±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
form powder
pka 14.02±0.40(Predicted)
color white to beige
InChIKey OINGHOPGNMYCAB-INIZCTEOSA-N
SMILES N1(C(NC(C)C)=O)CC[C@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C3=CC=C(Cl)C=C32)C1
UNSPSC Code 41106609
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313

NVS-PAK1-1 price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1867 NVS-PAK1-1 ≥98% (HPLC) 1783816-74-9 5MG $175 2026-04-30 Buy
Sigma-Aldrich SML1867 NVS-PAK1-1 ≥98% (HPLC) 1783816-74-9 25MG $699 2026-04-30 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 5mg $134 2026-04-30 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 10mg $240 2026-04-30 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 25mg $530 2026-04-30 Buy
Product number Packaging Price Buy
SML1867 5MG $175 Buy
SML1867 25MG $699 Buy
19964 5mg $134 Buy
19964 10mg $240 Buy
19964 25mg $530 Buy

NVS-PAK1-1 Chemical Properties, Uses, Production

Uses

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.

Biochem/physiol Actions

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

in vivo

NVS-PAK1-1 shows a relatively poor stability in rat liver microsomes (RLM) and this would limit its application for in vivo studies (t1/2 in RLM 3.5 min)[1].

storage

Store at -20°C

NVS-PAK1-1 Preparation Products And Raw materials

Raw materials

Preparation Products

NVS-PAK1-1 Suppliers

Global Suppliers ( 79)
Supplier Tel Email Country ProdList Advantage
Chengdu Celes Technology Co., Ltd 19982073091 2538834896@qq.com China 78 58
Deyang Sino Biotech. Co., LTD +86-19182167371 service@synlord.com China 110 58
Lexeon Biotech (Chengdu) Co., Ltd. 19982073091 3825580919@qq.com China 82 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4858 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Supplier Advantage
Chengdu Celes Technology Co., Ltd 58
Deyang Sino Biotech. Co., LTD 58
Lexeon Biotech (Chengdu) Co., Ltd. 58
Sigma-Aldrich 80
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghaizehan biopharma technology co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Chuzhou KeMail Chemical Technology Co., Ltd 55

View Latest Price from NVS-PAK1-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NVS-PAK1-1 pictures 2026-07-27 NVS-PAK1-1
1783816-74-9
 $44.00-177.00 99.74% 10g TargetMol Chemicals Inc.
  • NVS-PAK1-1 pictures
  • NVS-PAK1-1
    1783816-74-9
  • $44.00-177.00
  • 99.74%
  • TargetMol Chemicals Inc.

NVS-PAK1-1 Spectrum

NVS-PAK1-1(1783816-74-9)1HNMR

1783816-74-9 (NVS-PAK1-1) Related Search:

LMI070 N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine NVP-BSK805 NVP BGJ398 phosphate Infigratinib
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide NVP-CGM097

1of2

NVS-PAK1-1 (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)- NVS-PAK1-1 >=98% (HPLC) NVS-PAK11Chemicalbook (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11 NVS-PAK1-1, PAK1 inhibitor NVS-PAK1-1, 10 mM in DMSO NVS-PAK1-1 ，S8264 1783816-74-9 API