NVS-PAK1-1
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- CAS番号.
- 1783816-74-9
- 化学名:
- 别名:
- 英語名:
- NVS-PAK1-1
- 英語别名:
- NVS-PAK1-1;NVS-PAK1-1 ，S8264;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1, 10 mM in DMSO;NVS-PAK1-1, PAK1 inhibitor;NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
- CBNumber:
- CB63333615
- 化学式:
- C23H25ClF3N5O
- 分子量:
- 479.93
- MOL File:
- 1783816-74-9.mol
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NVS-PAK1-1 物理性質
- 沸点 :
- 697.8±55.0 °C(Predicted)
- 比重(密度) :
- 1.42±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
- 外見 :
- 粉
- 酸解離定数(Pka):
- 14.02±0.40(Predicted)
- 色:
- 白からベージュ
- InChIKey:
- OINGHOPGNMYCAB-INIZCTEOSA-N
- SMILES:
- N1(C(NC(C)C)=O)CC[C@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C3=CC=C(Cl)C=C32)C1
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
NVS-PAK1-1 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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SML1867 |
≥98% (HPLC)
NVS-PAK1-1 ≥98% (HPLC) |
1783816-74-9 |
5mg |
￥26300 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
|
SML1867 |
≥98% (HPLC)
NVS-PAK1-1 ≥98% (HPLC) |
1783816-74-9 |
25mg |
￥96800 |
2024-03-01 |
購入 |
NVS-PAK1-1 化学特性,用途語,生産方法
使用
NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.
Biochem/physiol Actions
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
NVS-PAK1-1 上流と下流の製品情報
原材料
準備製品
NVS-PAK1-1 生産企業
Global( 79)Suppliers
1783816-74-9()キーワード:
- 1783816-74-9
- NVS-PAK1-1
- (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
- NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1
- 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
- NVS-PAK1-1 >=98% (HPLC)
- NVS-PAK11Chemicalbook
- (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
- Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11
- NVS-PAK1-1, PAK1 inhibitor
- NVS-PAK1-1, 10 mM in DMSO
- NVS-PAK1-1 ，S8264