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ChemicalBook >> CAS DataBase List >>3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Structure
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone structure
CAS No.
408502-06-7
Chemical Name:
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone
Synonyms
KDR-in-4;VEGFR-2-IN-9;VEGFR 2 IN 9,VEGFR2IN9;3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[5-[2-[(2-methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-
CBNumber:
CB63339581
Molecular Formula:
C23H25N3O3
Molecular Weight:
391.4629
MDL Number:
MFCD30747898
MOL File:
408502-06-7.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Properties

Melting point 204-205 °C
Boiling point 651.5±55.0 °C(Predicted)
Density 1.235±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 11.55±0.70(Predicted)

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-7422 VEGFR-2-IN-9 408502-06-7 1mg $1744 2026-06-04 Buy
aablocks AA01EO4M VEGFR-2-IN-9 408502-06-7 1mg $580 2026-05-30 Buy
aablocks AA01EO4M VEGFR-2-IN-9 408502-06-7 5mg $1460 2026-05-30 Buy
ACHEMBLOCK AD248113 VEGFR-2-IN-9 98% 408502-06-7 1MG $840 2026-05-27 Buy
ACHEMBLOCK AD248113 VEGFR-2-IN-9 98% 408502-06-7 5MG $2160 2026-05-27 Buy
Product number Packaging Price Buy
CS-7422 1mg $1744 Buy
AA01EO4M 1mg $580 Buy
AA01EO4M 5mg $1460 Buy
AD248113 1MG $840 Buy
AD248113 5MG $2160 Buy

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Chemical Properties, Uses, Production

Uses

VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.

in vivo

KDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively[2].

IC 50

KDR: 7 nM (IC50)

References

[1] Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72(4):1341-6. DOI:10.1021/jo062228w
[2] Kinose F, et al. Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor. Molecular Vision 2005; 11:366-373

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Suppliers

Global Suppliers ( 16)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16103 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007 cis@bioss.com.cn China 9185 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
BOC Sciences 65
MedChemexpress LLC 58
TargetMol Chemicals Inc. 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
cjbscvictory 58
TargetMol Chemicals Inc. 58
Beijing Boorsen Biotechnology Co., Ltd 58
Shanghai Amole Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VEGFR-2-IN-9 pictures 2026-07-27 VEGFR-2-IN-9
408502-06-7
 $700.00-1800.00 97.19% 10g TargetMol Chemicals Inc.
VEGFR-2-IN-9 pictures 2026-07-27 VEGFR-2-IN-9
408502-06-7
 $700.00-1800.00 97.19% 10g TargetMol Chemicals Inc.
VEGFR-2-IN-9 pictures 2025-06-30 VEGFR-2-IN-9
408502-06-7
 $700.00-1800.00 97.19% 10g TargetMol Chemicals Inc.
  • VEGFR-2-IN-9 pictures
  • VEGFR-2-IN-9
    408502-06-7
  • $700.00-1800.00
  • 97.19%
  • TargetMol Chemicals Inc.
  • VEGFR-2-IN-9 pictures
  • VEGFR-2-IN-9
    408502-06-7
  • $700.00-1800.00
  • 97.19%
  • TargetMol Chemicals Inc.
  • VEGFR-2-IN-9 pictures
  • VEGFR-2-IN-9
    408502-06-7
  • $700.00-1800.00
  • 97.19%
  • TargetMol Chemicals Inc.

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Spectrum

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone(408502-06-7)1HNMR

408502-06-7 (3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone) Related Search:

2,4-PyriMidinediaMine with linker 3-nitro-N-(8-quinolinyl)benzamide 3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Vandetanib
FITC-LABELED VEGFR-2 Protein, HUMAN (HEK293, HIS)

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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone KDR-in-4 2(1H)-Quinolinone, 3-[5-[2-[(2-methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]- VEGFR-2-IN-9 VEGFR 2 IN 9,VEGFR2IN9 408502-06-7