3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone

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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone manufacturers

  • VEGFR-2-IN-9
  • VEGFR-2-IN-9 pictures
  • $700.00
  • 2026-07-27
  • CAS:408502-06-7
  • Purity: 97.19%
  • Supply Ability: 10g
  • VEGFR-2-IN-9
  • VEGFR-2-IN-9 pictures
  • $700.00
  • 2026-07-27
  • CAS:408502-06-7
  • Purity: 97.19%
  • Supply Ability: 10g
  • VEGFR-2-IN-9
  • VEGFR-2-IN-9 pictures
  • $700.00
  • 2025-06-30
  • CAS:408502-06-7
  • Purity: 97.19%
  • Supply Ability: 10g
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Basic information
Product Name:3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone
Synonyms:3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone;KDR-in-4;2(1H)-Quinolinone, 3-[5-[2-[(2-methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-;VEGFR-2-IN-9;VEGFR 2 IN 9,VEGFR2IN9
CAS:408502-06-7
MF:C23H25N3O3
MW:391.4629
EINECS:
Product Categories:
Mol File:408502-06-7.mol
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Structure
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Chemical Properties
Melting point 204-205 °C
Boiling point 651.5±55.0 °C(Predicted)
density 1.235±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka11.55±0.70(Predicted)
Safety Information
MSDS Information
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Usage And Synthesis
UsesVEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.
in vivo

KDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively[2].

IC 50KDR: 7 nM (IC50)
References[1] Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72(4):1341-6. DOI:10.1021/jo062228w
[2] Kinose F, et al. Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor. Molecular Vision 2005; 11:366-373
3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Preparation Products And Raw materials
Tag:3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone(408502-06-7) Related Product Information
2,4-PyriMidinediaMine with linker 3-nitro-N-(8-quinolinyl)benzamide 3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Vandetanib FITC-LABELED VEGFR-2 Protein, HUMAN (HEK293, HIS)