1-(4-Fluorophenyl)-2-pyrrolidinone
- CAS No.
- 54660-08-1
- Chemical Name:
- 1-(4-Fluorophenyl)-2-pyrrolidinone
- Synonyms
- BUTTPARK 32\07-63;1-(4-Fluorophenyl)-2-pyrrolidinone;1-(4-Fluorophenyl)pyrrolidin-2-one;1-(4-Fluorophenyl)-2-pyrrolidone97%;1-(4-Fluorophenyl)-2-pyrrolidone 97%;2-Pyrrolidinone, 1-(4-fluorophenyl)-;1-(4-Fluorophenyl)pyrrolidin-2-one 97%;1-(4-FLUOROPHENYL)-2-PYRROLIDINONE 99+%;1-(4-Fluorophenyl)pyrrolidin-2-one 95+%;1-(4-Fluorophenyl)-2-oxopyrrolidine, 1-Fluoro-4-(2-oxopyrrolidin-1-yl)benzene
- CBNumber:
- CB6348193
- Molecular Formula:
- C10H10FNO
- Molecular Weight:
- 179.19
- MDL Number:
- MFCD00138504
- MOL File:
- 54660-08-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| Hazard Note | Irritant |
| HS Code | 29339980 |
1-(4-Fluorophenyl)-2-pyrrolidinone price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC9696 | 1-(4-Fluorophenyl)pyrrolidin-2-one 95% | 54660-08-1 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS117041 | 1-(4-Fluorophenyl)pyrrolidin-2-one 95% | 54660-08-1 | 1g | $131 | 2026-06-04 | Buy |
| Activate Scientific | AS117041 | 1-(4-Fluorophenyl)pyrrolidin-2-one 95% | 54660-08-1 | 5g | $553 | 2026-06-04 | Buy |
| Matrix Scientific | 083797 | 1-(4-Fluorophenyl)pyrrolidin-2-one | 54660-08-1 | 1.00g | $230 | 2026-05-18 | Buy |
| Synthonix | F52399 | 1-(4-Fluorophenyl)pyrrolidin-2-one 95+% | 54660-08-1 | 100mg | $55 | 2026-05-06 | Buy |
1-(4-Fluorophenyl)-2-pyrrolidinone Chemical Properties, Uses, Production
Chemical Properties
beige crystalline powder
Synthesis
616-45-5
352-34-1
54660-08-1
General procedure for the synthesis of 1-(4-fluorophenyl)-2-pyrrolidinone from 2-pyrrolidinone and p-fluoroiodobenzene: N-nucleophilic reagent (2.21 mmol), Cu2O (Sigma-Aldrich, 99.99% purity, 0.147-0.294 mmol), K3PO4 (2.94 mmol), aryl halide (1.47 mmol), phase transfer catalyst (0.147-0.294 mmol) and water (0.40 mL) were sequentially added to the reaction vial and sealed by installing a screw cap. The reaction mixture was stirred in a closed system at 130 °C for 24 h under air atmosphere. Upon completion of the reaction, the non-homogeneous mixture was cooled to room temperature and diluted with dichloromethane. The resulting solution was filtered directly through diatomaceous earth. The organic extracts were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to afford the N-arylated product 1-(4-fluorophenyl)-2-pyrrolidinone. The structure and purity of the product were confirmed by 1H NMR and 13C NMR spectral analysis.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 11, p. 1169 - 1172
[2] Synlett, 2015, vol. 26, # 12, p. 1697 - 1701
[3] Advanced Synthesis and Catalysis, 2018, vol. 360, # 11, p. 2178 - 2182
1-(4-Fluorophenyl)-2-pyrrolidinone Preparation Products And Raw materials
Raw materials
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Preparation Products
1-(4-Fluorophenyl)-2-pyrrolidinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 1-(4-Fluorophenyl)-2-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE
54660-08-1
|
$1.00 | 1KG | 98% HPLC | 10t | Career Henan Chemical Co |
-
- 1-(4-FLUOROPHENYL)-2-PYRROLIDINONE
54660-08-1
- $1.00
- 98% HPLC
- Career Henan Chemical Co
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