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ChemicalBook >> CAS DataBase List >>1,3-Dichloroisoquinoline

1,3-Dichloroisoquinoline

1,3-Dichloroisoquinoline Structure
1,3-Dichloroisoquinoline structure
CAS No.
7742-73-6
Chemical Name:
1,3-Dichloroisoquinoline
Synonyms
oroisoquinoL;TIMTEC-BB SBB003563;1,3-DICHLOROISOQUINOLINE;isoquinoline, 1,3-dichloro-;1,3-Dichloroisoquinoline,97%;1,3-Dichloroisoquinoline >7742-73-6 1,3-Dichloroisoquinoline;1,3-Dichloroisoquinoline ISO 9001：2015 REACH;4-(AMINOMETHYL)-4-HYDROXY-1-METHYLPIPERIDINE
CBNumber:
CB6349044
Molecular Formula:
C9H5Cl2N
Molecular Weight:
198.05
MDL Number:
MFCD00034750
MOL File:
7742-73-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:09:06
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1,3-Dichloroisoquinoline Properties

Melting point 121-122 °C (lit.)
Boiling point 307°C(lit.)
Density 1.407±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
form powder to crystal
pka -1.49±0.50(Predicted)
color Light yellow to Brown to Dark green
InChI InChI=1S/C9H5Cl2N/c10-8-5-6-3-1-2-4-7(6)9(11)12-8/h1-5H
InChIKey BRGZEQXWZWBPJH-UHFFFAOYSA-N
SMILES C1(Cl)C2=C(C=CC=C2)C=C(Cl)N=1
CAS DataBase Reference 7742-73-6(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29163990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1,3-Dichloroisoquinoline price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 368830 1,3-Dichloroisoquinoline 97% 7742-73-6 5g $180 2026-04-30 Buy
TCI Chemical D4285 1,3-Dichloroisoquinoline >98.0%(GC) 7742-73-6 1g $56 2026-04-30 Buy
AstaTech CL1001 1,3-DICHLOROISOQUINOLINE 97% 7742-73-6 10G $33 2026-04-30 Buy
ChemScene CS-W002162 1,3-Dichloroisoquinoline ≥98% 7742-73-6 5g $15 2026-06-04 Buy
ChemScene CS-W002162 1,3-Dichloroisoquinoline ≥98% 7742-73-6 10g $24 2026-06-04 Buy
Product number Packaging Price Buy
368830 5g $180 Buy
D4285 1g $56 Buy
CL1001 10G $33 Buy
CS-W002162 5g $15 Buy
CS-W002162 10g $24 Buy

1,3-Dichloroisoquinoline Chemical Properties, Uses, Production

Chemical Properties

White to brown crystalline powder

Uses

1,3-Dichloroisoquinoline may be used in the facile synthesis of 1,3,4-trisubstituted isoquinoline derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5481, 1958 DOI: 10.1021/ja01553a042

General Description

1,3-Dichloroisoquinoline undergoes Pd(PPh3)4 catalyzed regioselective coupling with arylboronic acids to afford to 1-aryl-3-chloroisoquinolines. Reaction of amine with 1,3-dichloroisoquinoline has been studied. Regioselectivity of the Stille coupling reaction of (1-ethoxyvinyl)tri(n-butyl)stannane with 1,3-dichloroisoquinoline has been investigated.

Synthesis

1,2,3,4-Tetrahydroisoquinoline-1,3-dione

4456-77-3

1,3-Dichloroisoquinoline

7742-73-6

Example 60B Synthesis of 1,3-dichloroisoquinoline: The product of Example 60A, 1,3-[2H,4H]-isoquinolinedione (6.5 g, 40.4 mmol) was mixed with phenylphosphinic acid dichloride (11.5 mL, 81.1 mmol) and the reaction was heated for 3 hours at 160 °C. After the reaction was completed, it was cooled to room temperature and left to stand overnight. The reaction mixture was dissolved in tetrahydrofuran (200 mL) and hydrolyzed by adding water (60 mL), followed by concentration under reduced pressure to remove the tetrahydrofuran. The resulting aqueous phase was neutralized with concentrated NH4OH, followed by extraction with ethyl acetate. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford 1,3-dichloroisoquinoline as a yellow flaky solid (6.92 g, 74% yield).

References

[1] Patent: US2005/113576, 2005, A1. Location in patent: Page/Page column 30
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3651 - 3660
[3] Patent: US6340759, 2002, B1. Location in patent: Example 17
[4] Patent: WO2010/127855, 2010, A1. Location in patent: Page/Page column 136; 137

1,3-Dichloroisoquinoline Preparation Products And Raw materials

Raw materials

Homophthalic acid Phenylphosphonic dichloride Tetrahydrofuran Ethyl acetate Methanol
1,2-Dichlorobenzene Ammonia 1,2,3,4-Tetrahydroisoquinoline-1,3-dione 2-(Cyanomethyl)benzoic acid Water

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Preparation Products

1,3-Dichloro-5-nitro-isoquinoline 3-Chloro-1-(morpholinyl)-1-ylisoquinoline

1,3-Dichloroisoquinoline Suppliers

Global Suppliers ( 223)
Supplier Tel Email Country ProdList Advantage
Bellen Chemistry Co., Ltd. 010-60400365-8001 15910885229 service@bellenchem.com China 4514 60
Fuxin Kaituo Fine Chemical Technology Co., Ltd 15714082442 3757845877@qq.com China 343 58
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Bellen Chemistry Co., Ltd. 60
Fuxin Kaituo Fine Chemical Technology Co., Ltd 58
Tongchuang Pharma(Suzhou). Co., Ltd. 62
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Latest Price from 1,3-Dichloroisoquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-Dichloroisoquinoline pictures 2026-09-18 1,3-Dichloroisoquinoline
7742-73-6
 $5.00 1kg ≥98% 20mt/year Jinan Finer Chemical Co., Ltd
1,3-Dichloroisoquinoline pictures 2026-08-25 1,3-Dichloroisoquinoline
7742-73-6
 $2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1,3-Dichloroisoquinoline pictures 2026-08-20 1,3-Dichloroisoquinoline
7742-73-6
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

1,3-Dichloroisoquinoline Spectrum

1,3-Dichloroisoquinoline(7742-73-6)1HNMR1,3-Dichloroisoquinoline(7742-73-6)Raman1,3-Dichloroisoquinoline(7742-73-6)IR

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1,3-DICHLOROISOQUINOLINE TIMTEC-BB SBB003563 4-(AMINOMETHYL)-4-HYDROXY-1-METHYLPIPERIDINE 1,3-Dichloroisoquinoline,97% isoquinoline, 1,3-dichloro- 1,3-Dichloroisoquinoline > oroisoquinoL 1,3-Dichloroisoquinoline ISO 9001：2015 REACH 7742-73-6 1,3-Dichloroisoquinoline 7742-73-6 Building Blocks Isoquinolines Halogenated Heterocycles Heterocyclic Building Blocks Quinoline&Isoquinoline Heterocycle intermediates Heterocyclic Series Halogenated Heterocycles Heterocyclic Building Blocks Isoquinolines IsoquinolinesBuilding Blocks