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(S)-3-Hydroxy-gamma-butyrolactone

(S)-3-Hydroxy-gamma-butyrolactone structure

CAS No.: 7331-52-4

Chemical Name:: (S)-3-Hydroxy-gamma-butyrolactone

Synonyms: (S)-4-Hydroxydihydrofuran-2(3H)-one;(s)-(-)-á-hydroxy-;-4-Hydroxydihydrofuran-2(3H);(S)-3-Hydroxy-γ-butyrolactone;(S)-(-)-3-HYDROXYBUTYROLACTONE;(S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE;2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S);2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S);(S)-3-Hydroxy-gamma-;Levetiracetam Impurity 65

CBNumber:: CB6360496

Molecular Formula:: C4H6O3

Molecular Weight:: 102.09

MDL Number:: MFCD00211247

MOL File:: 7331-52-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:14:29

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(S)-3-Hydroxy-gamma-butyrolactone Properties

Boiling point	98-100 °C0.3 mm Hg(lit.)
Density	1.241 g/mL at 25 °C(lit.)
refractive index	n20/D 1.464(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
pka	12.87±0.20(Predicted)
Appearance	Brown to reddish brown Liquid
optical activity	[α]21/D 81°, c = 2 in ethanol
Water Solubility	Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum.
BRN	1280864
InChI	InChI=1S/C4H6O3/c5-3-1-4(6)7-2-3/h3,5H,1-2H2/t3-/m0/s1
InChIKey	FUDDLSHBRSNCBV-VKHMYHEASA-N
SMILES	O1C[C@@H](O)CC1=O
CAS DataBase Reference	7331-52-4(CAS DataBase Reference)
FDA UNII	2LIE7314JH
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

3-10

HS Code

29322090

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Inactive

NFPA 704

	0
2		0

(S)-3-Hydroxy-gamma-butyrolactone price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	422797	(S)-β-Hydroxy-γ-butyrolactone 96%	7331-52-4	1g	$75.4	2026-04-30	Buy
TCI Chemical	H0939	(S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC)	7331-52-4	1g	$53	2021-12-16	Buy
TCI Chemical	H0939	(S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC)	7331-52-4	5g	$149	2021-12-16	Buy
Biosynth	FH60203	(S)-3-Hydroxy-gamma-butyrolactone	7331-52-4	5g	$192.2	2026-06-04	Buy
Biosynth	FH60203	(S)-3-Hydroxy-gamma-butyrolactone	7331-52-4	10g	$346	2026-06-04	Buy

Product number	Packaging	Price	Buy
422797	1g	$75.4	Buy
H0939	1g	$53	Buy
H0939	5g	$149	Buy
FH60203	5g	$192.2	Buy
FH60203	10g	$346	Buy

(S)-3-Hydroxy-gamma-butyrolactone Chemical Properties, Uses, Production

Description

(S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer.

Chemical Properties

Colorless to light yellow liquid.

Uses

(S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.

Application

(S)-3-Hydroxy-gamma-butyrolactone is an important synthetic intermediate for a variety of chiral compounds. It is a key intermediate for preparing neuromediator (R)-GABOB, l-carnitine, and HMG-CoA reductase inhibitor, CI-981. (S)-3-Hydroxy-gamma-butyrolactone has been reported as a satiety and potentiating agent to neuroleptic drugs. It is widely used in the pharmaceutical industry as a chiral building block for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as well as the antibiotic Zyvox and the antihyperlipidemic medication Zetia. Other pharmaceuticals derived from 3HBL include HIV inhibitors and the nutritional supplement L-carnitine. 3HBL can readily be transformed into a variety of three-carbon building blocks and has been listed as one of the top value-added chemicals from biomass by the US Department of Energy[1-2].

Synthesis

Optically pure (S)-3-hydroxy-gamma-butyrolactone, a crucial chiral building block in the pharmaceutical industry, was synthesized from L: -malic acid by combining selective hydrogenation and lipase-catalyzed hydrolysis. Lipase from Candida rugosa was found to be the most efficient enzyme for the hydrolysis of (S)-beta-benzoyloxy-gamma-butyrolactone[1].

Precautions

For best results, Store in cool, dry place in tightly closed containers, under inert gas and protected from moisture as this substance is moisture sensitive. (S)-3-Hydroxy-gamma-butyrolactone is incompatible with oxidizing agents. This chemical causes skin irritation and serious eye irritation.

References

[1] Pradeep Kumar. “A simple and practical approach to enantiomerically pure (S)-3-hydroxy-γ-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester.” Tetrahedron, asymmetry 16 16 (2005): Pages 2717-2721.
[2] Sang-Hyun Lee, Hong-Sun Uh, Oh-Jin Park. “A chemoenzymatic approach to the synthesis of enantiomerically pure (S)-3-hydroxy-γ-butyrolactone.” Applied Microbiology and Biotechnology 79 3 (2008): 355–362.

(S)-3-Hydroxy-gamma-butyrolactone Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-3-Hydroxy-gamma-butyrolactone Suppliers

Global Suppliers ( 365)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Nanjing Jianao Pharmaceutical Technology Co., Ltd.	18915922978	497743262@qq.com	China	1000	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Shanghai YuLue Chemical Co., Ltd.	55
Nanjing Jianao Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59

(S)-3-Hydroxy-gamma-butyrolactone: Chiral Building Block
(S)-3-Hydroxy-gamma-butyrolactone is biosynthesized from glucose/xylose by engineered E. coli and yeast with pathway optimizat....
Jan 21,2026

View Latest Price from (S)-3-Hydroxy-gamma-butyrolactone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	(S)-3-Hydroxy-γ-butyrolactone 7331-52-4	$1.00	1kg	99%	10 tons	RongNa Biotechnology Co.,Ltd
2026-09-14	(S)-3-Hydroxy-gamma-butyrolactone 7331-52-4		2Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2026-08-26	(S)-3-Hydroxy-gamma-butyrolactone 7331-52-4		1kg	99%	99999	Rongchuang International

(S)-3-Hydroxy-γ-butyrolactone
7331-52-4
$1.00
99%
RongNa Biotechnology Co.,Ltd

(S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
$0.00
99% up, High Density
Sinoway Industrial co., ltd.

(S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
$0.00
99%
Rongchuang International

(S)-3-Hydroxy-gamma-butyrolactone Spectrum

(S)-3-Hydroxy-gamma-butyrolactone(7331-52-4)¹HNMR (S)-3-Hydroxy-gamma-butyrolactone(7331-52-4)IR

7331-52-4 ((S)-3-Hydroxy-gamma-butyrolactone) Related Search:

(-)-O-ACETYL-L-MALIC ANHYDRIDE L-Mannono-1,4-lactone D-(-)-Gulonic acid gamma-lactone 2,3-O-Isopropylidene-D-ribonic gamma-lactone (R)-(+)-3-Hydroxybutyrolactone

S(+)-3,3-DIMETHYL-2-HYDROXY-GAMMA-BUTYROLACTONE (S)-2-Hydroxy-gamma-butyrolactone,(S)-(-)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE,(S)-(-)-~-Hydroxy-gamma-butyrolactone, 94% (+/-)-3-hydroxy-gamma-butyrolactone 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate D-ERYTHRONOLACTONE

DL-Pantolactone D-Glucoheptono-1,4-lactone L-Galactono-1,4-lactone 2,3-O-Isopropylidene-D-erythronolactone 5-Bromo-5-deoxy-2,3-O-isopropylidene-D-ribonolactone

alpha-Hydroxy-gamma-butyrolactone (+)-Dibenzoyl-L-tartaric anhydride (R)-(+)-alpha-Hydroxy-gamma-butyrolactone

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2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S) 2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S) (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE (S)-4,5-DIHYDRO-4-HYDROXY-2(3H)-FURANONE (S)-(-)-3-HYDROXYBUTYROLACTONE (S)-3-HYDROXYBUTYROLACTONE (S)-(-)-3-HYDROXY-GAMA-BUTYROLACTONE (S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE (S)-3-HYDROXY-GAMMA-BUTYROLACTONE (S)-(-)-BETA-HYDROXY-GAMMA-BUTYROLACTONE (S)-BETA-HYDROXY-GAMMA-BUTYROLACTONE (s)-(-)-á-hydroxy- (S)-(-)-BETA-HYDROXY-GAMMA-BUTYROLACTONE , EE 99% (S)-(-)-SS-HYDROXY-GAMMA-BUTYROLACTONE: 94% (S)-(-)--HYDROXY-G-BUTYROLACTONE 4(S)-Hydroxytetrahydrofuran-2-ONE (S)-(-)-b-Hydroxy-g-butyrolactone (S)-DIHYDRO-4-HYDROXY-2(3H)-FURANONE (S)-(-)-~-Hydroxy-gamma-butyrolactone, 97%, ee 99% (S)-(-)-^b-Hydroxy-^y-butyrolactone, 97%, ee 99% (S)-(-)-β-Hydroxy-γ-butyrolactone, 97%, ee 99% (S)-(-)-^b-Hydroxy-^y-butyrolactone, 94% S-(-)-3-Hydroxy-gammalactone (S)-3-Hydroxy-γ-butyrolactone ,98% (S)-3-Hydroxy-gamma- 2(3H)-Furanone,dihydro-4-hydroxy-, (4S)- (S)-beta-Hydroxy-gamma-butyrolactone 96% (S)-(-)-3-Hydroxy-g-butyrolactone -4-Hydroxydihydrofuran-2(3H) (S)-3-Hydroxy-gamma-butyrolactone,97% (S)-(-)-beta-Hydroxy-gamma-butyrolactone, 97%, ee 99% (S)-3-Hydroxy-γ-butyrolactone> (4S)-4-Hydroxytetrahydrofuran-2-one (S)-β-Hydroxy-γ-butyrolactone S)-3-Hydroxy-gamma-butyrolactttone Tetramethylene Glycol powder (S)-3-Hydroxyl group-gamma-Butyl lactone (S)-3-Hydroxy-gamma-butyrolactone 7331-52-4 Levetiracetam Impurity 65 (S)-3-Hydroxy-gamma-butyroctone Phenyl Acetate Impurity 61 (S)-β-Hydroxy-γ-butyrolactone (s)-β-hydroxy-γ-butyrolactone (S)-β-Hydroxy-γ-butyrolactone (S)-β-Hydroxy-γ-butyrolactone, CAS 7331-52-4 (S)-4-Hydroxydihydrofuran-2(3H)-one (S)-3-Hydroxy-γ-butyrolactone 7331-52-4 73311-52-4 Asymmetric Synthesis Chiral Building Blocks Simple Alcohols (Chiral) Lactones Organic Building Blocks Chiral Building Blocks Simple Alcohols (Chiral) Synthetic Organic Chemistry Tetrahydrofuran Series