Z-VDVAD-FMK
- CAS No.
- 210344-92-6
- Chemical Name:
- Z-VDVAD-FMK
- Synonyms
- Z-VDVAD-FMK;CASPASE-2 INHIBITOR I;Z-VD(OME)VAD(OME)-FMK;Z-VDVAD-FLUOROMETHYLKETONE;Z-Val-Asp(OMe)-Val-Ala-Asp-FMK;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VD(OME)VAD(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE
- CBNumber:
- CB6364843
- Molecular Formula:
- C32H46FN5O11
- Molecular Weight:
- 695.73
- MDL Number:
- MFCD03452881
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 980.097±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.228±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | −20°C |
| solubility | DMSO/DMF: 20 mM |
| form | powder |
| pka | 11.002±0.46(predicted) |
| color | white |
| biological source | synthetic (organic) |
| InChIKey | ANTIWMNLIROOQF-IREHUOSBSA-N |
| SMILES | COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Z-VDVAD-FMK price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 218744 | Caspase-2 Inhibitor I The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. | 250μG | $222 | 2026-04-30 | Buy | |
| Sigma-Aldrich | C1605 | Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone powder, ≥95% (TLC) | 210344-92-6 | 1mg | $586 | 2026-04-30 | Buy |
| Sigma-Aldrich | 218744 | Caspase-2 Inhibitor I The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. | 1MG | $618 | 2026-04-30 | Buy | |
| Cayman Chemical | 17484 | Z-VDVAD-FMK ≥98% | 210344-92-6 | 1mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 17484 | Z-VDVAD-FMK ≥98% | 210344-92-6 | 5mg | $355 | 2026-04-30 | Buy |
Z-VDVAD-FMK Chemical Properties,Uses,Production
Uses
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].
Biological Activity
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Biochem/physiol Actions
A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.
IC 50
Caspase-2
References
1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.
Z-VDVAD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
