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| | Z-VDVAD-FMK Basic information |
| Product Name: | Z-VDVAD-FMK | | Synonyms: | BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;CASPASE-2 INHIBITOR I;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-VDVAD-FLUOROMETHYLKETONE;Z-VDVAD-FMK | | CAS: | 210344-92-6 | | MF: | C32H46FN5O11 | | MW: | 695.73 | | EINECS: | | | Product Categories: | Caspases/Apoptosis;Caspase/Related Products | | Mol File: | Mol File |  |
| | Z-VDVAD-FMK Chemical Properties |
| Boiling point | 980.097±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.228±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | −20°C | | solubility | DMSO/DMF: 20 mM | | form | powder | | pka | 11.002±0.46(predicted) | | color | white | | biological source | synthetic (organic) | | InChIKey | ANTIWMNLIROOQF-IREHUOSBSA-N | | SMILES | COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Z-VDVAD-FMK Usage And Synthesis |
| Uses | Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3]. | | Biological Activity | Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. | | Biochem/physiol Actions | A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition. | | IC 50 | Caspase-2 | | references | 1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223. |
| | Z-VDVAD-FMK Preparation Products And Raw materials |
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