Tris(2-Methoxyphenyl)phosphine
- CAS No.
- 4731-65-1
- Chemical Name:
- Tris(2-Methoxyphenyl)phosphine
- Synonyms
- tris(2-Methoxyphenyl)phosphane;NSC 93545;Tris(o-methoxyphenyL;Tris(2-methoxyphenyl);Tri(o-anisyl)phosphine;TRIS(O-ANISYL)PHOSPHINE;TRIS-(2-ANISYL)PHOSPHINE;TRI(2-METHOXYPHENYL)PHOSPHINE;TRIS(O-METHOXYPHENYL)PHOSPHINE;TRIS(2-METHOXYPHENYL)PHOSPHINE
- CBNumber:
- CB6421041
- Molecular Formula:
- C21H21O3P
- Molecular Weight:
- 352.36
- MDL Number:
- MFCD00014892
- MOL File:
- 4731-65-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 204-208 °C |
|---|---|
| Boiling point | 477.3±40.0 °C(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| color | Colorless to yellow or pale orange |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Air Sensitive |
| BRN | 2776186 |
| InChI | InChI=1S/C21H21O3P/c1-22-16-10-4-7-13-19(16)25(20-14-8-5-11-17(20)23-2)21-15-9-6-12-18(21)24-3/h4-15H,1-3H3 |
| InChIKey | IIOSDXGZLBPOHD-UHFFFAOYSA-N |
| SMILES | P(C1=CC=CC=C1OC)(C1=CC=CC=C1OC)C1=CC=CC=C1OC |
| CAS DataBase Reference | 4731-65-1(CAS DataBase Reference) |
| FDA UNII | H64XF7T8LW |
| UNSPSC Code | 12352112 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H413 | |||||||||
| Precautionary statements | P273-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Chronic 4 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Tris(2-Methoxyphenyl)phosphine price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S543160 | TRIS(2-METHOXYPHENYL)PHOSPHINE AldrichCPR | 4731-65-1 | 1 unit | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | S543160 | TRIS(2-METHOXYPHENYL)PHOSPHINE AldrichCPR | 4731-65-1 | 250mg | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 710563 | Tris(o-methoxyphenyl)phosphine 96% | 4731-65-1 | 1g | $52.7 | 2023-01-07 | Buy |
| TCI Chemical | T3005 | Tris(2-methoxyphenyl)phosphine >97.0%(HPLC) | 4731-65-1 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | T3005 | Tris(2-methoxyphenyl)phosphine >97.0%(HPLC) | 4731-65-1 | 5g | $132 | 2026-04-30 | Buy |
Tris(2-Methoxyphenyl)phosphine Chemical Properties,Uses,Production
Synthesis
2-liter reaction vessel equipped with a thermometer, mechanical stirrer, dropping funnel, and reflux condenser was connected to an inert gas source and loaded with 113 g (1.04 mol) of anisole and 250 ml of MTBE. After degassing, 440 ml (0.70 mol) of n-butyllithium (1.6 M in hexane) was added over 1 hour, during which time the temperature was gradually increased to the reflux temperature (approximately 60 °C). After maintaining this temperature for 16 hours, the reactor contents were cooled to ambient temperature (at which point GC analysis showed a n-butyllithium conversion > 99%, with the formation of a corresponding amount of 2-thioanisole). Next, a mixture of 100 ml of MTBE and 19.3 ml (31.0 g, 0.225 mol) of phosphorus trichloride was added at a rate not exceeding 30 °C. After the addition was complete, the white/yellow suspension was stirred for another 4 hours. Subsequently, 30 ml of water was added, and the white precipitate was filtered off. Next, the white solid was washed with methanol (2 × 200 ml), filtered, and dried under vacuum (1 mbar, 60 °C). Yield: 63.4 g (80%) of a fine white powder, which, according to 1H NMR and 31P NMR, is >99% pure TOMPP.
Chemical Properties
white powder or crystals
Uses
suzuki reaction
Uses
Tris(2-methoxyphenyl)phosphine is a phosphine ligand used for catalysis. It is used as a catalyst for allylic substitution of simple alkenes, suzuki coupling reactions, hydrogenation of quinolines and other addition reactions.
Hazard
Tris(2-Methoxyphenyl)phosphine causes skin irritation and serious eye irritation, and may cause long lasting harmful effects to aquatic life.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
Chemical Reactivity
Treatment of the diiron hexacarbonyl complexes [μ-SCH2CH(R)S-μ]Fe2(CO)6 with a monophosphine ligand tris(2-methoxyphenyl)phosphine in the presence of Me3NO 2H2O gave monosubstituted complexes [μ-SCH2CH(R)S-μ]Fe2(CO)5[P(C6H4OCH3-2)3] in 60–89% yields.
References
[1] Raymond C. Bott, Graham Smith, Peter C. Healy. “Structural studies of two-coordinate complexes of tris(2-methoxylphenyl)phosphine and tris(4-methoxyphenyl)phosphine with gold(I) halides.” Polyhedron 26 12 (2007): Pages 2803-2809.
[2] O. Shawkataly. “Pentacarbonyl[tris(2-methoxyphenyl)phosphine-P]chromium and its Molybdenum Analogue.” Acta crystallographica. Section C, Crystal structure communications 75 1 (1996): 1352–1355.
Tris(2-Methoxyphenyl)phosphine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Xishaonian biotechnology co., ltd | 0711-3700636 18827410479 | xujin@boronicgroup.com | China | 50 | 58 |
| BeiJing Greenchem Technology Co.,Ltd. | 131-21959385 18804271668 | chemrocking@bjgreenchem.com | China | 272 | 58 |
| Henan Research New Material Co., Ltd. | 86-18903931531 18903931628 | sales036@researchvip.com | China | 180 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Lastest Price from Tris(2-Methoxyphenyl)phosphine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Tris(2-methoxyphenyl)phosphine
4731-65-1
|
$26.00-86.00 | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-08-07 | Tris(2-Methoxyphenyl)phosphine
4731-65-1
|
$1.00 | 1KG | 99% | 20 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-06-30 | Tris(2-Methoxyphenyl)phosphine
4731-65-1
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Tris(2-methoxyphenyl)phosphine
4731-65-1
- $26.00-86.00
- 0.98
- Shanghai UCHEM Inc.
-
- Tris(2-Methoxyphenyl)phosphine
4731-65-1
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Tris(2-Methoxyphenyl)phosphine
4731-65-1
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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