3,4-Dihydroxyphenylacetic acid methyl ester
- CAS No.
- 25379-88-8
- Chemical Name:
- 3,4-Dihydroxyphenylacetic acid methyl ester
- Synonyms
- methyl 2-(3,4-dihydroxyphenyl)acetate;METHYL 3,4-DIHYDROXYPHENYLACETATE;CATECHOL-4-ACETIC ACID METHYL ESTER;Methyl3,4-Dihydroxyphenylacetate>Chatechol-4-acetic acid methyl ester;HOMOPROTOCATECHUIC ACID METHYL ESTER;PYROCATECHOL-4-ACETIC ACID METHYL ESTER;3,4-Dihydroxyphenylacetic acid methyl ester;3,4-Dihydroxybenzeneacetic Acid Methyl Ester;2-(3,4-dihydroxyphenyl)acetic acid methyl ester
- CBNumber:
- CB6430698
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00583539
- MOL File:
- 25379-88-8.mol
- MSDS File:
- SDS
| Melting point | 36 °C |
|---|---|
| Boiling point | 335.0±27.0 °C(Predicted) |
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.48±0.12(Predicted) |
| color | White to Brown |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HS Code | 2918290090 | |||||||||
| NFPA 704 |
|
3,4-Dihydroxyphenylacetic acid methyl ester price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D2734 | Methyl 3,4-Dihydroxyphenylacetate >98.0%(GC) | 25379-88-8 | 1g | $37 | 2026-04-30 | Buy |
| TCI Chemical | D2734 | Methyl 3,4-Dihydroxyphenylacetate >98.0%(GC) | 25379-88-8 | 5g | $186 | 2026-04-30 | Buy |
| Cayman Chemical | 30637 | Methyl 3,4-Dihydroxyphenylacetate ≥98% | 25379-88-8 | 250mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 30637 | Methyl 3,4-Dihydroxyphenylacetate ≥98% | 25379-88-8 | 500mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 30637 | Methyl 3,4-Dihydroxyphenylacetate ≥98% | 25379-88-8 | 1g | $283 | 2026-04-30 | Buy |
3,4-Dihydroxyphenylacetic acid methyl ester Chemical Properties, Uses, Production
Synthesis
(1) Add 520g of 10% dilute hydrochloric acid aqueous solution to the reaction vessel, add 100g of 3,4-dimethoxyphenylacetic acid and 1.53g of glacial acetic acid while stirring at room temperature; after the addition is complete, react at 80℃ for 6h; take a sample, and HPLC detect that the reaction of the raw materials is complete; lower the reaction solution to 60℃, remove water by vacuum distillation, add 200mL of isopropyl ether to the remaining oily substance, and then freeze in the refrigerator (0℃) overnight, precipitate a white solid, filter, wash the filter cake with isopropyl ether, and dry at 55℃ to obtain pure 3,4-dihydroxyphenylacetic acid, 83.5g, with a yield of 96.9%. (2) Add 100 mL of methanol to a reaction vessel, and add 83.5 g of 3,4-dihydroxyphenylacetic acid under stirring at room temperature. After it is completely dissolved, add 4.98 g of concentrated hydrochloric acid (mass fraction 36%). After the addition is complete, react at 56 °C for 1 h. Take a sample and check by HPLC to see if the reaction is complete. Cool the reaction solution to room temperature, concentrate under reduced pressure to recover methanol, add 100 mL of water to the remaining oily substance, and then extract with methyl tert-butyl ether. Collect the organic layer and dry it. Concentrate to dryness to obtain 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER, 89.5 g, with a yield of 98.4%.
Chemical Properties
Off-White to Brown Solid
Uses
3,4-Dihydroxyphenylacetic Acid Methyl Ester is a biogenic amine metabolite. 3,4-Dihydroxyphenylacetic Acid Methyl Ester is used in the preparation of antioxidants and bacteriostatic agents. It is used in the synthesis of noncompetitive AMPA receptor antagonists as benzodiazepines, as well as optically active quinolones with dopaminergic properties.
3,4-Dihydroxyphenylacetic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
View Latest Price from 3,4-Dihydroxyphenylacetic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Methyl 3,4-Dihydroxyphenylacetate
25379-88-8
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-06-30 | 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER
25379-88-8
|
1kg | 98% | 10000kgS | Shaanxi Dideu New Materials Co. Ltd |
-
- Methyl 3,4-Dihydroxyphenylacetate
25379-88-8
- $0.00
- TargetMol Chemicals Inc.
-
- 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER
25379-88-8
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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