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Methyl phenylacetate

Methyl phenylacetate Structure
Methyl phenylacetate structure
CAS No.
101-41-7
Chemical Name:
Methyl phenylacetate
Synonyms
Methyl 2-phenylacetate;Methylphenylacetat;PHENYLACETIC ACID METHYL ESTER;Methyl benzeneacetate;FEMA 2733;2-phenylpropanoate;Mephaneine;METHYL A-TOLUATE;METHYLPAROXETINE;METHYL-PHENYLACETAT
CBNumber:
CB1333473
Molecular Formula:
C9H10O2
Molecular Weight:
150.17
MDL Number:
MFCD00008453
MOL File:
101-41-7.mol
MSDS File:
SDS
Last updated:2026-06-24 18:39:39
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Methyl phenylacetate Properties

Melting point 107-115 °C
Boiling point 218 °C (lit.)
Density 1.066 g/mL at 20 °C (lit.)
vapor pressure 16.9-75Pa at 20℃
FEMA 2733 | METHYL PHENYLACETATE
refractive index n20/D 1.503(lit.)
FLAVIS Number 09.783 | Methyl phenylacetate
Flash point 195 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly)
color Colourless
Specific Gravity 1.07
Odor at 10.00 % in dipropylene glycol. sweet floral honey spice waxy almond
Odor Type honey
biological source synthetic
Water Solubility Miscible with water.
Merck 14,7268
JECFA Number 1008
BRN 878795
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChI 1S/C9H10O2/c1-11-9(10)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChIKey CRZQGDNQQAALAY-UHFFFAOYSA-N
SMILES COC(=O)Cc1ccccc1
LogP 1.91-2.09 at 21.9-25℃
CAS DataBase Reference 101-41-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) METHYL PHENYLACETATE
FDA 21 CFR 172.515
EWG's Food Scores 1
FDA UNII D4PDC41X96
NIST Chemistry Reference Benzeneacetic acid, methyl ester(101-41-7)
EPA Substance Registry System Methyl phenylacetate (101-41-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H227-H303
Precautionary statements  P210e-P280a-P370+P378a-P403+P235-P501a
Hazard Codes  Xn
Risk Statements  21-R21
Safety Statements  23-24/25
WGK Germany  2
RTECS  AJ3175000
TSCA  TSCA listed
HS Code  29163500
Storage Class 10 - Combustible liquids
Hazardous Substances Data 101-41-7(Hazardous Substances Data)
Toxicity The acute oral LD50 in rats was reported as 2.55 g/kg (1.67-3.43 g/kg) and the acute dermal LD50 in rabbits as 2.4 g/kg (0.15-4.7 g/kg) (Moreno, 1974).
REACH Registrations Active
NFPA 704
2
0 0

Methyl phenylacetate price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W273309 Methyl phenylacetate ≥98%, FCC, FG 101-41-7 1 each $58 2026-04-30 Buy
Sigma-Aldrich W273309 Methyl phenylacetate ≥98%, FCC, FG 101-41-7 1kg $84.4 2026-04-30 Buy
Sigma-Aldrich W273309 Methyl phenylacetate ≥98%, FCC, FG 101-41-7 10Kg $473 2026-04-30 Buy
Sigma-Aldrich 108057 Methyl phenylacetate ReagentPlus , ≥99% 101-41-7 100g $45.6 2026-04-30 Buy
Sigma-Aldrich W273309 Methyl phenylacetate ≥98%, FCC, FG 101-41-7 1 unit $53.48 2025-07-31 Buy
Product number Packaging Price Buy
W273309 1 each $58 Buy
W273309 1kg $84.4 Buy
W273309 10Kg $473 Buy
108057 100g $45.6 Buy
W273309 1 unit $53.48 Buy

Methyl phenylacetate Chemical Properties, Uses, Production

Chemical Properties

Methyl phenylacetate is a clear colorless liquid that is only slightly soluble in water, but very soluble in most organic solvents. It has a strong odor similar to honey. The odor is so strong that recommended smelling is of a solution with 10% or less methyl phenyl acetate. This compound also naturally occurs in brandy, capsicum, coffee, honey, pepper and some wine.

Occurrence

Reported found in cocoa, coffee, strawberry, pineapple, pepper, hop oil, cognac, peanut, honey, starfruit, Bourbon vanilla, mountain papaya, roasted chicory root and rooibus tea (Aspalathus linearis).

Uses

Methyl phenylacetate is utilized for partition coefficient measurement experiments. It is mainly used in the flavor industry and in perfumes to impart honey scents. Further, it acts as a precursor to prepare synthetic perfumes. It acts as an acylating agent and involved in the enantioselective acylation of beta-lactam intermediate using penicillin G amidase.

Preparation

Methyl phenylacetate is synthesized from phenylacetonitrile by hydrolysis and esterification. Put methanol into a dry glass-lined reaction pot, stir and cool to below 30°C, add sulfuric acid dropwise, heat up to 90°C after adding, and start adding phenylacetonitrile dropwise, control the temperature at about 95°C, and finish adding in 1.5h. After reacting at 95-100 °C for 6 h, it was cooled to below 40 °C and diluted with water equivalent to about 0.6 times the reaction solution. The acid water was separated by standing, and a saturated sodium carbonate solution was added for neutralization and washing, and the aqueous layer was discarded. It is dehydrated with anhydrous calcium chloride and fractionated under reduced pressure to obtain methyl phenylacetate with a yield of 80%.

Application

Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid; a lichen metabolite with anti-inflammatory properties. It is also used in the formulation of edible flavors, for the preparation of honey, chocolate, tobacco and other flavors; it can also be used in daily chemical flavors for the preparation of rose, oriental flavors and other flavors. IFRA has no restrictions.

Definition

ChEBI: Methyl benzeneacetate is a member of benzenes. It is a flavoring ingredient. Odoriferous constituent of many plants. It is generally found in brandy, capsicum, honey, pepper, some wine, coca and coca products.

Aroma threshold values

Detection: 25 ppb

Taste threshold values

Taste characteristics at 30 ppm: floral, fruity, honey, spice, waxy and sweet

Synthesis Reference(s)

Journal of the American Chemical Society, 93, p. 4919, 1971 DOI: 10.1021/ja00748a051
Tetrahedron Letters, 30, p. 2945, 1989 DOI: 10.1016/S0040-4039(00)99165-2

General Description

Methyl phenylacetate has been identified in the volatile fraction of beewax absolute oil, dried fruiting bodies of Boletus auripes, Chinese fermented black soybeans and peated malt.

Biochem/physiol Actions

Methyl phenylacetate undergoes decomposition on photolysis in methanol. Methyl phenylacetate acts as acylating agent and causes the enantioselective acylation of beta-lactam intermediate using penicillin G amidase. Methyl phenylacetate is the starting material in manufacture of synthetic perfumes.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Methyl phenylacetate synthesis

616-38-6
103-79-7
101-41-7
Synthesis of Methyl phenylacetate from Dimethyl carbonate and Phenylacetone

Methyl phenylacetate Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Benzeneacetonitrile Metaclazepam Methanol Sulfuric acid
Phenylacetic acid

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Preparation Products

N-Isopropylnortropinyl a hydroxymethyl)phenylacetate Tropic acid 8-isopropyl-8-azabicyclo[3.2.1]oct-3-yl endo-(±)-formylphenylacetate Tropyl a ormulphenylacetate Fluoxastrobin
Methyl -formylphenylacetate Methyl alpha-bromophenylacetate 1,3-Diphenylacetone Methyl alpha-L-rhamnopyranoside α-(Hydroxymethyl)benzenacetic acid methyl ester
2-Phenylmalonamide methyl 2-(4-(chlorosulfonyl)phenyl)acetate Methyl p-nitrophenylacetate N,N-Diethyl-2-phenylacetamide 2-Isopropyl-2-phenylacetic acid
4-Chloromethylphenylacetic acid methyl ester Methyl 2-(2-bromophenyl)acetate (2-Methoxyethyl)benzene Phenylacetic acid isobutyl ester 2-isopropyl-5-methylcyclohexyl phenylacetate

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Methyl phenylacetate Suppliers

Global Suppliers ( 585)
Supplier Tel Email Country ProdList Advantage
hebei crovell biotech Co,.LTD 19930503252 mia@crovellbio.com China 1457 58
XI'AN VEDA CHEMICAL CO.,LTD 029-88665278 18392371173 cordelia@vedachem.com China 50 58
Henan Guosheng Chemical Co., Ltd 17610068021 1185586080@QQ.COM China 13 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jinxiang Chemical (Danyang) Products Co., Ltd. 025-86819862 13913839793 nancyzong@jinchemical.com China 97 74
Supplier Advantage
hebei crovell biotech Co,.LTD 58
XI'AN VEDA CHEMICAL CO.,LTD 58
Henan Guosheng Chemical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Jinxiang Chemical (Danyang) Products Co., Ltd. 74

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View Latest Price from Methyl phenylacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl phenylacetate pictures 2026-09-17 Methyl phenylacetate
101-41-7
 0.99 RongNa Biotechnology Co.,Ltd
Methyl phenylacetate pictures 2026-09-02 Methyl phenylacetate
101-41-7
 $1.20-31.00 1kg 99% Henan Fengda Chemical Co., Ltd
Methyl phenylacetate pictures 2026-09-01 Methyl phenylacetate
101-41-7
 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd

Methyl phenylacetate Spectrum

Methyl phenylacetate(101-41-7)MSMethyl phenylacetate(101-41-7)1HNMRMethyl phenylacetate(101-41-7)13CNMRMethyl phenylacetate(101-41-7)IR1Methyl phenylacetate(101-41-7)Raman

101-41-7 (Methyl phenylacetate) Related Search:

Methyl salicylate Methyl acrylate Methyl isobutyrylacetate Methyl acetate Tribenuron methyl
Methyl phenoxyacetate Methyl cyanoacetate Kresoxim-methyl Methyl bromoacetate Pirimiphos-methyl
Thiophanate-methyl Metsulfuron methyl Methyl 8-Azoniabicyclo[3.2.1]octane, 8-methyl-8-(1-methylethyl)-3-[(phenylacetyl)oxy]-, bromide, (endo,syn)- (9CI) 3α-Phenylacetoxy Tropane
endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Benzeneacetic acid, α-methylene-, 1-methylethyl ester Atropic acid

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