DISUCCINIMIDYL SUCCINATE
- CAS No.
- 30364-60-4
- Chemical Name:
- DISUCCINIMIDYL SUCCINATE
- Synonyms
- Bis(2,5-dioxopyrrolidin-1-yl) succinate;N,N'-(Succinyldioxy)disuccinimide;DISUCCINIMIDYL SUCCINATE;Bis(2,5-dioxopyrrolidin-1-yl);Succinic Acid Disuccinimidyl Ester;Bis(2,5-dioxo-1-pyrrolidinyl) Succinate;bis(2,5-dioxypyrolidine-1-yl)acylisoamine;bis(2,5-dioxopyrrolidin-1-yl) butanedioate;SUCCINIC ACID-BIS-N-HYDROXYSUCCINIMIDE ESTER;SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER
- CBNumber:
- CB6448859
- Molecular Formula:
- C12H12N2O8
- Molecular Weight:
- 312.23
- MDL Number:
- MFCD00228233
- MOL File:
- 30364-60-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 305-306℃ |
|---|---|
| Boiling point | 471.6±55.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
DISUCCINIMIDYL SUCCINATE price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S283339 | SUCCINIC ACID BIS-(2,5-DIOXO-PYRROLIDIN-1-YL) ESTER AldrichCPR | 30364-60-4 | 25MG | $179 | 2024-03-01 | Buy |
| TCI Chemical | D5622 | Disuccinimidyl Succinate | 30364-60-4 | 250MG | $31 | 2026-04-30 | Buy |
| TCI Chemical | D5622 | Disuccinimidyl Succinate | 30364-60-4 | 1G | $84 | 2026-04-30 | Buy |
| TRC | TRC-B016172-500MG | Bis(2,5-dioxopyrrolidin-1-yl) succinate | 30364-60-4 | 500mg | $784 | 2026-06-03 | Buy |
| TRC | TRC-B016172-250MG | Bis(2,5-dioxopyrrolidin-1-yl) succinate | 30364-60-4 | 250mg | $498 | 2026-06-03 | Buy |
DISUCCINIMIDYL SUCCINATE Chemical Properties, Uses, Production
Uses
DISUCCINIMIDYL SUCCINATE can be used as a crosslinking agent.
Synthesis
6066-82-6
110-15-6
30364-60-4
General procedure for the synthesis of bis(2,5-dioxopyrrolidin-1-yl) succinic acid esters from N-hydroxybutanediimide and butanedioic acid: to a solution of THF (50 mL) of butanedioic acid (30 g, 254 mmol, 1.0 eq.) was added a solution of THF (50 mL) of N-hydroxybutanediimide (64 g, 556 mmol, 2.2 eq.). A THF (50 mL) solution of N,N'-dicyclohexylcarbodiimide (DCC, 11.5 g, 55.8 mmol, 0.22 eq.) was slowly added dropwise with stirring at 0 °C. After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS). After completion of the reaction, the solid was collected by filtration and the filtrate was concentrated to obtain the crude product. The resulting solid was washed sequentially with THF and ethanol to give the final bis(2,5-dioxopyrrolidin-1-yl) succinate (24 g, 27% yield) as a white solid.
References
[1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 291
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, # 5, p. 785 - 789
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 5, p. 1078 - 1081
[4] Chemical Papers, 2016, vol. 70, # 4, p. 505 - 514
[5] Patent: WO2016/205488, 2016, A1. Location in patent: Paragraph 0264
DISUCCINIMIDYL SUCCINATE Preparation Products And Raw materials
Raw materials
Preparation Products
DISUCCINIMIDYL SUCCINATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai D&B Biological Science and Technology Co.Ltd | 400-008-9730,021-54359730 400-008-9730 | info@chemxyz.com | China | 3642 | 60 |
| Shanghai CanSpecsci Instrument Co., Ltd. | 400-6087598 15021221957 | order@canspecsci.com | China | 2001 | 56 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
View Latest Price from DISUCCINIMIDYL SUCCINATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-25 | DISUCCINIMIDYL SUCCINATE
30364-60-4
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | DISUCCINIMIDYL SUCCINATE
30364-60-4
|
1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- DISUCCINIMIDYL SUCCINATE
30364-60-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- DISUCCINIMIDYL SUCCINATE
30364-60-4
- $0.01
- 98%; 99%
- Career Henan Chemical Co
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