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SULFISOMIDINE

SULFISOMIDINE Structure
SULFISOMIDINE structure
CAS No.
515-64-0
Chemical Name:
SULFISOMIDINE
Synonyms
SULFISOMIDIN;Sulfaisodimidine;Sulfadimetine;Domian;erycon;Elcosin;Elkosil;Elkosin;Mefenal;Elcosine
CBNumber:
CB6455785
Molecular Formula:
C12H14N4O2S
Molecular Weight:
278.33
MDL Number:
MFCD00010567
MOL File:
515-64-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Request For Quotation

SULFISOMIDINE Properties

Melting point 245°C
Boiling point 294°C (rough estimate)
Density 1.2997 (rough estimate)
refractive index 1.6440 (estimate)
storage temp. 0-6°C
solubility Acetonitrile (Slightly), DMSO (Slightly)
form Solid
pka pKa 7.25 (Uncertain)
color White to Off-White
Water Solubility 1.382g/L(25 ºC)
Merck 8951
BRN 261305
FDA UNII W03L3ODK6E
ATC code J01EB01

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
RIDADR  3249
WGK Germany  2
RTECS  WO9270000
HazardClass  6.1(b)
PackingGroup  III

SULFISOMIDINE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46908 Sulfisomidin VETRANAL?, analytical standard 515-64-0 250mg $53.6 2022-05-15 Buy
ChemScene CS-7658 Sulfisomidin 99.75% 515-64-0 100mg $43 2026-06-04 Buy
Matrix Scientific 136051 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 515-64-0 1.00g $101 2026-05-18 Buy
Matrix Scientific 136051 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 515-64-0 2.50g $215 2026-05-18 Buy
Matrix Scientific 136051 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 515-64-0 5.00g $323 2026-05-18 Buy
Product number Packaging Price Buy
46908 250mg $53.6 Buy
CS-7658 100mg $43 Buy
136051 1.00g $101 Buy
136051 2.50g $215 Buy
136051 5.00g $323 Buy

SULFISOMIDINE Chemical Properties, Uses, Production

Originator

Elkosin,Ciba,US,1951

Uses

Sulfisomidine is a sulfanilamide antibacterial agent.

Definition

ChEBI: A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.

Manufacturing Process

This starting material can be prepared as follows. 123 parts of finely powdered 6-amino-2,4-dimethylpyrimidine are suspended in 250 parts of dry pyridine and 222 parts of p-nitrobenzenesulfonyl chloride added at 50°C to 55°C. The whole is then warmed for 2 hours to 55°C. Water is added to the crystalline aggregate obtained, the precipitated bis-N-(pnitrobenzenesulfonyl)- 6-amino-2,4-dimethylpyrimidine filtered off by suction and washed with water. It is purified by recrystallizing from methyl ethyl ketone. On slowly heating it decomposes; on rapidly heating it melts at about 210°C to 215°C with decomposition.
49.3 parts of bis-N-(p-nitrobenzenesulfonyl)-6-amino-2,4-dimethylpyrimidine are heated to boiling for one hour with 12.3 parts of 6-amino-2,4- dimethylpyrimidine in 50 parts of dry pyridine. After cooling, the 6-(pnitrobenzenesulfonamido)- 2,4-dimethylpyrimidine formed is precipitated with water and filtered off by suction. It is purified by dissolving in dilute caustic soda and precipitating with acid. On recrystallization from dilute alcohol it melts (with decomposition) at 188°C to 189°C.
On reaction, for example, with iron and hydrochloric acid, 6-(paminobenzenesulfonamido)- 2,4-dimethylpyrimidine, melting point 236°C is obtained.

brand name

Isosulf;Oestro-gynedron;Poly-gynedron;Sulfamethine;Tricho-gynedron.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sulfisomide, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfisomide is still used topically in some countries for vaginal infection.

Pharmaceutical Applications

6-Sulfanilamido-2,4-dimethylpyrimidine (syn: sulphasomidine). A highly soluble sulfonamide with a plasma half-life of 6–8 h. Protein binding is about 90%. Activity is similar to that of sulfadiazine. It is less extensively metabolized than most other sulfonamides and is largely excreted unchanged in the urine.

SULFISOMIDINE synthesis

121-60-8
515-64-0
Synthesis of SULFISOMIDINE from N-Acetylsulfanilyl chloride

SULFISOMIDINE Preparation Products And Raw materials

Raw materials

Hydrochloric acid 4-Nitrobenzenesulfonyl chloride

Preparation Products

SULFISOMIDINE Suppliers

Global Suppliers ( 161)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 marketing_china@spectrumchemical.com China 9643 60
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Shandong Xiya Chemical Co., Ltd 57
Syntechem Co.,Ltd 57
Sichuan Kulinan Technology Co., Ltd 57
Maya High Purity Chemicals 57
Spectrum Chemical Manufacturing Corp. 60
9ding chemical ( Shanghai) Limited 55
MedChemexpress LLC 58

View Latest Price from SULFISOMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulfisomidin pictures 2026-08-08 Sulfisomidin
515-64-0
 $31.00 99.95% 10g TargetMol Chemicals Inc.
SULFISOMIDINE pictures 2019-07-06 SULFISOMIDINE
515-64-0
 $1.00 1G 98% 100KG Career Henan Chemical Co

SULFISOMIDINE Spectrum

SULFISOMIDINE(515-64-0)MSSULFISOMIDINE(515-64-0)1HNMRSULFISOMIDINE(515-64-0)13CNMRSULFISOMIDINE(515-64-0)IR1SULFISOMIDINE(515-64-0)IR2

515-64-0 (SULFISOMIDINE) Related Search:

SULFISOMIDINE Sulfaclomid 4-Amino-2,6-dimethylpyrimidine Sulfanilamide SULFISOMIDINE, SODIUM
AURORA 9455 AURORA 22995 AURORA 11359 AURORA 7318 AURORA 1185
AURORA 10804 AURORA 8501 AURORA 10892 AURORA 7814 AURORA 22997
N-(4-(((2,6-Dimethylpyrimidin-4-yl)amino)sulfonyl)phenyl)-2-thienylformamide 2-Acetyl-3-((4-(((2,6-dimethylpyrimidin-4-yl)amino)sulfonyl)phenyl)amino)-N-phenylprop-2-enamide 2-(((4-(((2,6-Dimethylpyrimidin-4-yl)amino)sulfonyl)phenyl)amino)methylene)indane-1,3-dione

1of4

(p-aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidine 2,4-Dimethyl-6-sulfanilamidopyrimidine 2,6-Dimethyl-4-sulfanilamidopyrimidine 4-amino-n-(2,6-dimethyl-4-pyrimidinyl)-benzenesulfonamid 4-Sulfa-2,6-dimethylpyrimidine 4-Sulfanilamido-2,6-dimethylpyrimidine 6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine 6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine 6-(p-aminophenylsulfonamido)-2,4-dimethylpyrimidine 6-[(p-aminobenzenesulfonyl)amino]-2,4-dimethylpyrimidine 6-Sulfanilamido-2,4-dimethylpyrimidine Aristamid Aristamide Aristogyn Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- benzenesulfonamide,4-amino-N-(2,6-dimethyl-4-pyrimidinyl)- Domian Elcosin N1-(2,6-DIMETHYLPYRIMIDIN-4-YL)SULFANILAMIDE SULFISOMIDINE Elcosine Elkosil Elkosin Elkosine erycon Mefenal n(sup1)-(2,6-dimethyl-4-pyrimidinyl)-sulfanilamid n(sup1)-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide N1-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide N1-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide Sulfaisodimerazine Sulfaisodimidine Sulfamethin Sulfanilamide, N1-(2,6-dimethyl-4-pyrimidinyl)- sulfanilamide,N1-(2,6-dimethyl-4-pyrimidinyl)- Sulfasomidine Sulphasomidine AKOS BBS-00004571 4-AMINO-N-(2,6-DIMETHYL-4-PYRIMIDINYL)BENZENESULFONAMIDE N1-(2,6-dimethylpyrimidin-4-yl)sulphanilamide SULPHISOMIDINE SULFISOMIDINE STANDARD 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide, N1-(2,6-Dimethylpyrimidin-4-yl)sulfanilamide 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide 4-azanyl-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide SULFISOMIDIN VETRANAL Sulfisomidine solution,100ppm (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin [German] 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI) 6-(p-Aminobenzenesulfo Sulfisomidine (JAN) Sulfisomidine (TN) Sulfisomidine > Sulfisomidine Solution in Methanol, 1000μg/mL SULFISOMIDINE USP/EP/BP Sulfisomidine (Sulfaisodimidine)