3-Methyl-8-quinolinesulphonyl chloride
- CAS No.
- 74863-82-4
- Chemical Name:
- 3-Methyl-8-quinolinesulphonyl chloride
- Synonyms
- Argatroban Impurity 29;Argatraban Intermediate;Argatraban Intermediate -2;3-Methylquinoline-8-sulfonyl;8-CHLOROSULFONYL-3-METHYLQUINOLINE;3-METHYL-8-QUINOLINESULFONYL CHLORIDE;3-methylquinoline-3-sulfonyl chloride;8-Quinolinesulfonyl chloride, 3-methyl-;3-METHYL-8-QUINOLINE SULPHONYL CHLORIDE;3-methyl quinoline-8-sulphonyl chloride
- CBNumber:
- CB6460864
- Molecular Formula:
- C10H8ClNO2S
- Molecular Weight:
- 241.69
- MDL Number:
- MFCD02683367
- MOL File:
- 74863-82-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 158-159°C |
|---|---|
| Boiling point | 371.5±27.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 0.82±0.28(Predicted) |
| color | White to Pale Brown |
| Stability | Moisture Sensitive - Store Under Inert Atmosphere |
| InChI | InChI=1S/C10H8ClNO2S/c1-7-5-8-3-2-4-9(15(11,13)14)10(8)12-6-7/h2-6H,1H3 |
| InChIKey | XCMAYGDQKTWICK-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2S(Cl)(=O)=O)C=C(C)C=1 |
| CAS DataBase Reference | 74863-82-4(CAS DataBase Reference) |
| FDA UNII | D6J3GW33J6 |
3-Methyl-8-quinolinesulphonyl chloride price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM25759 | 3-Methyl-8-quinolinesulfonyl chloride | 74863-82-4 | 25g | $327.25 | 2026-06-04 | Buy |
| Biosynth | FM25759 | 3-Methyl-8-quinolinesulfonyl chloride | 74863-82-4 | 50g | $519.5 | 2026-06-04 | Buy |
| Biosynth | FM25759 | 3-Methyl-8-quinolinesulfonyl chloride | 74863-82-4 | 100g | $810 | 2026-06-04 | Buy |
| Biosynth | FM25759 | 3-Methyl-8-quinolinesulfonyl chloride | 74863-82-4 | 250g | $1825 | 2026-06-04 | Buy |
| Biosynth | FM25759 | 3-Methyl-8-quinolinesulfonyl chloride | 74863-82-4 | 500g | $3375 | 2026-06-04 | Buy |
3-Methyl-8-quinolinesulphonyl chloride Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Brown Solid
Uses
3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.
Synthesis
612-58-8
74863-82-4
The general procedure for the synthesis of 3-methylquinoline-8-sulfonyl chloride from 3-methylquinoline was as follows: 3-methylquinoline (5.2 g, 36 mmol) was slowly added to 9 mL (135 mmol) of chlorosulfonic acid at 0°C with reference to U.S. Patent Nos. 4,522,576 and 5,332,822. After removing the ice bath, the reaction mixture was stirred at 100 °C overnight. After the reaction mixture was cooled to room temperature, 3.3 mL (45 mmol) of thionyl chloride was added, followed by heating at 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and carefully quenched with ice (note: this step is highly reactive). The reaction mixture was diluted with 100 mL of water and extracted with dichloromethane (100 mL). The organic phase was washed with water, dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was ground with a solvent mixture of dichloromethane/ether to give 1.58 g (18% yield) of 3-methylquinoline-8-sulfonyl chloride as a brown solid. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 9.17-9.29 (m, 2H), 8.32-8.38 (m, 2H), 7.96 (dd, 1H, J = 7Hz), and 2.51 (t, 3H, J = 2Hz).
References
[1] Patent: US6235778, 2001, B1
3-Methyl-8-quinolinesulphonyl chloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xeon Biopharmaceutical Limited | 0512-67302433 | 3223436747@qq.com | China | 16 | 55 |
| Shandong RuiYue Biotechnology Co., Ltd. | 0531-88581623 18805314509 | 1456922171@126.com | China | 63 | 50 |
| Beijing Faith-zone Pharmaceutical Technology Co.,Ltd | -- | 2848440175@qq.com | China | 24 | 58 |
| Xinxiang Junlong Biotechnology Co., Ltd | +86-15517316871 15517316871 | 1225342923@qq.com | China | 23 | 58 |
| Bayee Biotech (Anqing) Co., Ltd. | 0556-5032306 18917961636 | wtx@bayeebio.com | China | 145 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemvon Biotechnology Co., Ltd | 021-50790412 | info@chemvon.com | China | 371 | 57 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 3-Methyl-8-quinolinesulphonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
|
1KG | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-02-02 | 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-12-29 | 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
|
1kg | 90%,97% | Changzhou waston chemical technology Co.,Ltd |
-
- 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Methyl-8-quinolinesulphonyl chloride
74863-82-4
- $0.00
- 90%,97%
- Changzhou waston chemical technology Co.,Ltd
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