Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Iodixanol

Iodixanol

Iodixanol Structure
Iodixanol structure
CAS No.
92339-11-2
Chemical Name:
Iodixanol
Synonyms
OptiPrep;Visipaque;Iothalamate;DU-6807;Ioxanol;Ioxaxol;odixanol;Acupaque;lodoanol;IODIXANOL
CBNumber:
CB6465056
Molecular Formula:
C35H44I6N6O15
Molecular Weight:
1550.18
MDL Number:
MFCD00867965
MOL File:
92339-11-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-01 20:51:29
Request For Quotation

Iodixanol Properties

Melting point 262-267°C (dec.)
Boiling point 1250.9±65.0 °C(Predicted)
Density 1.266 ±0.003
vapor pressure 0Pa at 20℃
refractive index n 1.4128 ±0.0003
storage temp. Refrigerator
solubility Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
pka 11.04±0.46(Predicted)
form liquid
color White
Major Application pharmaceutical (small molecule)
InChIKey NBQNWMBBSKPBAY-UHFFFAOYSA-N
SMILES C(N(C1C(I)=C(C(NCC(O)CO)=O)C(I)=C(C(NCC(O)CO)=O)C=1I)C(C)=O)C(O)CN(C1C(I)=C(C(NCC(O)CO)=O)C(I)=C(C(NCC(O)CO)=O)C=1I)C(C)=O
LogP 0.7
FDA UNII HW8W27HTXX
NCI Drug Dictionary iodixanol
ATC code V08AB09
EPA Substance Registry System 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
UNSPSC Code 41116107
NACRES NA.75

SAFETY

Risk and Safety Statements

WGK Germany  WGK 1
HS Code  2924296000
Storage Class 11 - Combustible Solids
Hazardous Substances Data 92339-11-2(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 21 gI/kg (Palmers)
REACH Registrations Active

Iodixanol price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001294 Iodixanol European Pharmacopoeia (EP) Reference Standard 92339-11-2 40 mg $254 2026-04-30 Buy
Sigma-Aldrich PHR3015 Iodixanol pharmaceutical secondary standard, certified reference material 92339-11-2 500MG $267 2026-04-30 Buy
Sigma-Aldrich D1556 OptiPrep™ Density Gradient Medium used for cell and subcellular organelle isolation 92339-11-2 250 mL $373 2026-04-30 Buy
Sigma-Aldrich 1343517 Iodixanol 92339-11-2 200mg $501 2026-04-30 Buy
Sigma-Aldrich Y0001294 Iodixanol European Pharmacopoeia (EP) Reference Standard 92339-11-2 y0001294 $220 2024-03-01 Buy
Product number Packaging Price Buy
Y0001294 40 mg $254 Buy
PHR3015 500MG $267 Buy
D1556 250 mL $373 Buy
1343517 200mg $501 Buy
Y0001294 y0001294 $220 Buy

Iodixanol Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

OptiPrep,Nycomed Pharma,Norway

Uses

Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).

Definition

ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Manufacturing Process

Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal (0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2 (42.5 ml) was added through a dropping funnel over 1 hour. The solution was heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g) was suspended in acetic anhydride (480 ml) and heated to 50°C. Concentrated sulfuric acid (3 ml) was then added. The starting material was dissolved after a few minutes, and the reaction mixture was heated at 60°C for 75 min. After cooling the residue dissolved in methanol (300 ml) with water (150 ml) the solution was heated to 50°C and the pH adjusted to about 10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and the hydrolysis was complete. The reaction mixture was cooled to 20°C and neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido- 2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophtalamide (304 g) was added after two hours of stirring. All solids were allowed to dissolve overnight before cooling to 30°C and adjustment to pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the solution after further cooling to 15°C, and the reaction was allowed to proceed for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was obtained.

brand name

Visipaque (GE Healthcare).

Therapeutic Function

Diagnostic aid

General Description

Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.

Iodixanol synthesis

31127-80-7
106-89-8
66108-95-0
92339-11-2
Synthesis of Iodixanol from 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide and Epichlorohydrin

Iodixanol Preparation Products And Raw materials

Raw materials

1,3-Dichloro-2-propanol Sulfuric acid Dimethyl 5-nitroisophthalate Epichlorohydrin Sodium hydroxide
Hydrochloric acid 2-Methoxyethanol Acetic anhydride

1of2

Preparation Products

Iodixanol Suppliers

Global( 330)Suppliers
Supplier Tel Email Country ProdList Advantage
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 18171815831 1341138380@qq.com China 4572 58
Hunan Eurasian Pharmaceutical Co. Ltd. 0592-5789919 13328776692 2851802018@qq.com;2851802016@qq.com China 88 58
Hubei widely chemical technology Co., Ltd. 186-02735115 18602735115 18602735115@163.com China 1896 64
Wuhan Augda Biotechnology Co., Ltd 15071299552 262933239@qq.com China 7200 58
ZHEJIANG HICHIPHARMACEUTICALCORPORATION LIMITED 13958554356 15715702293 sales@hichipharm.com China 11 58
Xiamen keerda Biotechnology Co., Ltd 0592-5639388; 18060983084 753760940@qq.com China 132 58
Anhui Wanbang Pharmaceutical Technology Co.，Ltd. 18019594105 18705138015 liuhaitao@ahwbyy.cn China 9 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Supplier Advantage
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 58
Hunan Eurasian Pharmaceutical Co. Ltd. 58
Hubei widely chemical technology Co., Ltd. 64
Wuhan Augda Biotechnology Co., Ltd 58
ZHEJIANG HICHIPHARMACEUTICALCORPORATION LIMITED 58
Xiamen keerda Biotechnology Co., Ltd 58
Anhui Wanbang Pharmaceutical Technology Co.，Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
LGM Pharma 70

Related articles

View Lastest Price from Iodixanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Iodixanol pictures 2026-09-12 Iodixanol
92339-11-2
 0.99 RongNa Biotechnology Co.,Ltd
Iodixanol pictures 2026-09-11 Iodixanol
92339-11-2
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Iodixanol. pictures 2026-09-11 Iodixanol.
92339-11-2
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Iodixanol pictures
  • Iodixanol
    92339-11-2
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • Iodixanol pictures
  • Iodixanol
    92339-11-2
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Iodixanol. pictures
  • Iodixanol.
    92339-11-2
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

92339-11-2(Iodixanol)Related Search:

Acetylspiramycin Ioversol Epichlorohydrin N1,N3-Bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanamido)-2,4,6-triiodoisophthalamide Acetaminophen
Trimethylolpropane Acetylsalicylic acid Acetylthiocholine iodide Propylene oxide Acetylcholine
Chlorophosphonazo III 5-Amino-N,N'-bis(2,3-dihydroxypropyl)isophthalamide 1,3-BIS(DIMETHYLAMINO)-2-PROPANOL 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Haloperidol
5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Iohexol C 29

1of4

Acupaque DU-6807 5-[acetyl-[3-[N-acetyl-3,5-bis[(2,3-dihydroxypropylamino)-oxomethyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol (200 mg) 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetyliMino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- odixanol IODIXANOL 1,3-benzenedicarboxamide,5,5’-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis n’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-( 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- 2-5410-3A 5,5'-((2-Hydroxy-1,3-propanediyl)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide 5,5'-[(2-Hydroxytrimethylene)bis(acetylimino)]bis[N,N/1-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide iodexanol 5-[acetyl-[3-[N-acetyl-3,5-bis[[(2S)-2,3-dihydroxypropyl]carbamoyl]-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis[(2S)-2,3-dihydroxypropyl]-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol CRS 5,5'-((2-hydroxypropane-1,3-diyl)bis(acetylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) Iodixanol USP/EP/BP lodoanol Iodixanol (Visipaque, Iodixanolum, OptiPrep) IodixanolQ: What is Iodixanol Q: What is the CAS Number of Iodixanol Q: What is the storage condition of Iodixanol Q: What are the applications of Iodixanol Iodixanol (1343517) Ioxanol Ioxaxol 5,5'-((2-Hydroxypropane-1,3-diyl)bis(acetylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) , Iodixanol C14330000 Iodixanol 5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol, 10 mM in DMSO OptiPrep? Density Gradient Medium 5-{N-[3-(N-{3,5-bis[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodophenyl}acetamido)-2-hydroxypropyl]acetamido}-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Iodixanol (Mixture of Diastereomers) Iothalamate OptiPrep Visipaque Iodixanol material Iodixanol material powder 92339-11-2 922339-11-2 16253-78-3 C35H44I6N6O15 Aromatics Diagnostic Intermediates & Fine Chemicals Pharmaceuticals 92339-11-2