Endothelin-3 (human, rat) (trifluoroacetate salt)
- CAS No.
- Chemical Name:
- Endothelin-3 (human, rat) (trifluoroacetate salt)
- Synonyms
- Endothelin-3 (human, rat) (trifluoroacetate salt)
- CBNumber:
- CB64665953
- Molecular Formula:
- C121H168N26O33S4
- Molecular Weight:
- 2643.04302
- MDL Number:
- MOL File:
- Mol file
Endothelin-3 (human, rat) (trifluoroacetate salt) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24413 | Endothelin-3 (human, rat) (trifluoroacetate salt) ≥95% | 500μg | $481 | 2026-04-30 | Buy | |
| Cayman Chemical | 24413 | Endothelin-3 (human, rat) (trifluoroacetate salt) ≥95% | 1mg | $626 | 2026-04-30 | Buy | |
| Cayman Chemical | 24413 | Endothelin-3 (human, rat) (trifluoroacetate salt) ≥95% | 100μg | $191 | 2022-04-27 | Buy | |
| Cayman Chemical | 24413 | Endothelin-3 (human, rat) (trifluoroacetate salt) ≥95% | 250μg | $334 | 2022-04-27 | Buy |
Endothelin-3 (human, rat) (trifluoroacetate salt) Chemical Properties, Uses, Production
Description
Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively. It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.
References
[1] JANET J. MAGUIRE . Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways[J]. Life sciences, 2012, 91 13: Pages 544-549. DOI: 10.1016/j.lfs.2012.03.021
[2] T X WATANABE. Effects of endothelin-1 and endothelin-3 on blood pressure in conscious hypertensive rats.[J]. Journal of Cardiovascular Pharmacology, 1989, 13 Suppl 5: S207-8. DOI: 10.1097/00005344-198900135-00059
[3] E. GAZQUEZ. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep37877
Endothelin-3 (human, rat) (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Endothelin-3 (human, rat) (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
