Urotensin II (human) (trifluoroacetate salt)
- CAS No.
- Chemical Name:
- Urotensin II (human) (trifluoroacetate salt)
- Synonyms
- Urotensin II (human) (trifluoroacetate salt)
- CBNumber:
- CB14666809
- Molecular Formula:
- C66H86F3N13O20S2
- Molecular Weight:
- 1502.5893496
- MDL Number:
- MOL File:
- Mol file
Urotensin II (human) (trifluoroacetate salt) price More Price(1)
Urotensin II (human) (trifluoroacetate salt) Chemical Properties,Uses,Production
Description
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).1 It increases intracellular calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM). Urotensin II increases the level of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells and induces proliferation, an effect that is inhibited by depletion of NADPH oxidase subunits.2 Urotensin II potently induces contraction of isolated rat thoracic aorta with an EC50 of 0.8 nM.1 It also induces contraction of isolated cynomolgus monkey arterial, but not venous, vessels and, when administered at doses greater than 100 pmol/kg, can lead to severe myocardial depression and fatal circulatory collapse.WARNING This product is not for human or veterinary use.
References
[1] ROBERT S. AMES. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14[J]. Nature, 1999, 401 6750: 282-286. DOI: 10.1038/45809
[2] H ZENG. Transport of amphipathic anions by human multidrug resistance protein 3.[J]. Cancer research, 2000, 60 17: 4779-4784.
Urotensin II (human) (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Urotensin II (human) (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
