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PSI-7977-13C-d3

PSI-7977-13C-d3 Structure
PSI-7977-13C-d3 structure
CAS No.
2070009-25-3
Chemical Name:
PSI-7977-13C-d3
Synonyms
PSI-7977-13C-d3;13C,D3-Sofosbuvir;[13C,2H3]-Sofosbuvir;L-Alanine, N-[[P(S),2′R]-2′-deoxy-2′-fluoro-2′-(methyl-13C-d3)-P-phenyl-5′-uridylyl]-, 1-methylethyl ester;isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-13C-d3)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;Sofosbuvir 13CD3Q: What is Sofosbuvir 13CD3 Q: What is the CAS Number of Sofosbuvir 13CD3 Q: What is the storage condition of Sofosbuvir 13CD3 Q: What are the applications of Sofosbuvir 13CD3
CBNumber:
CB64666758
Molecular Formula:
C22H26D3FN3O9P
Molecular Weight:
533.46
MDL Number:
MOL File:
2070009-25-3.mol
MSDS File:
SDS
Last updated:2025-08-20 16:56:22
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PSI-7977-13C-d3 Properties

Density 1.413±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml
form A solid

PSI-7977-13C-d3 price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25045 PSI-7977-13C-d3 ≥99%deuteratedforms(d1-d3) 2070009-25-3 1mg $502 2026-04-30 Buy
Usbiological 463192 PSI-7977-13CD3 1mg $531 2026-06-03 Buy
Usbiological 463192 PSI-7977-13CD3 10mg $3079 2026-06-03 Buy
Biosynth VHD00925 Psi-7977-13C-d3 2070009-25-3 1mg $1060.31 2026-06-05 Buy
Biosynth VHD00925 Psi-7977-13C-d3 2070009-25-3 5mg $2996.5 2026-06-05 Buy
Product number Packaging Price Buy
25045 1mg $502 Buy
463192 1mg $531 Buy
463192 10mg $3079 Buy
VHD00925 1mg $1060.31 Buy
VHD00925 5mg $2996.5 Buy

PSI-7977-13C-d3 Chemical Properties, Uses, Production

Description

PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.

Uses

PSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

References

[1] EISUKE MURAKAMI. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.[J]. The Journal of Biological Chemistry, 2010, 285 45: 34337-34347. DOI: 10.1074/jbc.m110.161802
[2] MICHAEL J. SOFIA*. Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus[J]. Journal of Medicinal Chemistry, 2010, 53 19: 7202-7218. DOI: 10.1021/jm100863x
[3] ANGELA M LAM. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 6: 3359-3368. DOI: 10.1128/aac.00054-12
[4] EDWARD J GANE. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.[J]. The New England Journal of Medicine, 2013: 34-44. DOI: 10.1056/nejmoa1208953
[5] ERIC LAWITZ. Sofosbuvir for previously untreated chronic hepatitis C infection.[J]. New England Journal of Medicine, 2013, 368 20: 1878-1887. DOI: 10.1056/nejmoa1214853

PSI-7977-13C-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

PSI-7977-13C-d3 Suppliers

Global Suppliers ( 21)
Supplier Tel Email Country ProdList Advantage
ANHUI WITOP BIOTECH CO., LTD +8618071025641 eric@witopchemical.com China 23504 58
Shanghai Payne Pharmaceutical Technology Co.Ltd 021-58123769 17721400256 info@paynepharm.com China 1283 58
Shanghai Payne Pharmaceutical Technology Co.Ltd 021-58123769 18678586262 info@paynepharm.com China 1352 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4721 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 judy.xia@synzest.com China 12577 58
Hubei Moco Chemical Co., Ltd. 18627753421; 18627756402 3001051413@qq.com China 20010 58
TLC Pharmaceutical Standards Ltd. 18012923235 18012923235 chinasales04@tlcstandards.com.cn China 7839 58
ShangHai ZskBio CO., LTD 021-58056897 15399714481 info@zsklab.com China 7539 58
Supplier Advantage
ANHUI WITOP BIOTECH CO., LTD 58
Shanghai Payne Pharmaceutical Technology Co.Ltd 58
Shanghai Payne Pharmaceutical Technology Co.Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
CHINA ISOTOPE CO., LIMITED 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Hubei Moco Chemical Co., Ltd. 58
TLC Pharmaceutical Standards Ltd. 58
ShangHai ZskBio CO., LTD 58

2070009-25-3 (PSI-7977-13C-d3) Related Search:

Sofosbuvir Impurity 8 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Cytidine,N-benzoyl-2^-C-Methyl-,3^,5^-dibenzoate(9CI) Sofosbuvir Sofosbuvir IMpurity
((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-Methyltetrahydrofuran-2-yl)Methyl benzoate Sofosbuvir Impurity 19 PSI-7976 Sofosbuvir D6 Sofosbuvir Impurity
Sofosbuvir metabolites GS566500 Sofosbuvir metabolites PSI 7411 Sofosbuvir Impurity 32 PSI-6206 13CD3
(2R,3R,4R,5S)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-fluoro-4-Methyltetrahydrofuran-3-yl benzoate alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate PSI 352707-13C,d3

1of4

[13C,2H3]-Sofosbuvir isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-13C-d3)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate Sofosbuvir 13CD3Q: What is Sofosbuvir 13CD3 Q: What is the CAS Number of Sofosbuvir 13CD3 Q: What is the storage condition of Sofosbuvir 13CD3 Q: What are the applications of Sofosbuvir 13CD3 PSI-7977-13C-d3 L-Alanine, N-[[P(S),2′R]-2′-deoxy-2′-fluoro-2′-(methyl-13C-d3)-P-phenyl-5′-uridylyl]-, 1-methylethyl ester 13C,D3-Sofosbuvir 2070009-25-3 C2113CH26D3FN3O9P