1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE
- CAS No.
- 61216-62-4
- Chemical Name:
- 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE
- Synonyms
- SAPE;1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE;2-Ammonioethyl ((R)-2-(((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl)oxy)-3-(stearoyloxy)propyl) phosphate;5Z,8Z,11Z,14Z-eicosatetraenoicacid,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethylester;5,8,11,14-Eicosatetraenoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z)-
- CBNumber:
- CB64666879
- Molecular Formula:
- C43H78NO8P
- Molecular Weight:
- 768.07
- MDL Number:
- MFCD00674346
- MOL File:
- 61216-62-4.mol
- MSDS File:
- SDS
| Boiling point | 776.1±70.0 °C(Predicted) |
|---|---|
| Density | 1.013±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Ethanol:PBS (pH 7.2)(1:2): 1 mg/ml; Methanol: 10 mg/ml |
| pka | 1.17±0.50(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChIKey | ANRKEHNWXKCXDB-BHFWLYLHSA-N |
| SMILES | [H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O |
| UNSPSC Code | 51191904 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372-H412 | |||||||||
| Precautionary statements | P201-P273-P301+P312+P330-P302+P352-P304+P340+P311-P308+P313 | |||||||||
| target organs | Central nervous system, Liver,Kidney | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Carc. 2 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 STOT RE 1 STOT SE 3 |
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| NFPA 704 |
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1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25871 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE ≥95% | 61216-62-4 | 1mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 25871 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE ≥95% | 61216-62-4 | 5mg | $125 | 2026-04-30 | Buy |
| Cayman Chemical | 25871 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE ≥95% | 61216-62-4 | 10mg | $220 | 2026-04-30 | Buy |
| Cayman Chemical | 25871 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE ≥95% | 61216-62-4 | 25mg | $482 | 2026-04-30 | Buy |
| Cayman Chemical | 25871 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE ≥95% | 61216-62-4 | 1 mg | $50 | 2024-03-01 | Buy |
1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Chemical Properties, Uses, Production
Description
1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE is a naturally-occurring phospholipid that is formed via the phosphatidylserine decarboxylation pathway in mammalian cells. It has been used in the generation of giant unilamellar vesicles for use in the study of biological membranes.
Uses
18:0-20:4 PE maybe used in the preparation of liposomes.
Uses
SAPE is used in the mRNA combination therapy for treatment of cancer.
Definition
ChEBI: 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine zwitterion is a phosphatidylethanolamine 38:4 zwitterion obtained by transfer of a proton from the phosphate to the primary amino group of 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine; major species at pH 7.3. It is a phosphatidylethanolamine 38:4 zwitterion and a 1-stearoyl-2-acyl-sn-glycero-3-phosphoethanolamine zwitterion. It is a tautomer of a 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine.
References
[1] ONNO B BLEIJERVELD. The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.[J]. The Journal of Biological Chemistry, 2007, 282 39: 28362-28372. DOI: 10.1074/jbc.m703786200
[2] BILLERIT C, JEFFRIES G D M, ORWAR O, et al. Formation of giant unilamellar vesicles from spin-coated lipid films by localized IR heating[J]. Soft Matter, 2012, 42: 10823-10826. DOI: 10.1039/c2sm26394g
1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Preparation Products And Raw materials
Raw materials
Preparation Products
1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8041 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9894 | 58 |
| Sichuan Yiyan Pharmaceutical Research | 19949968070; 19949968070 | 2904199885@qq.com | China | 922 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 18901678489 | tech@zzbioco.com | China | 12062 | 58 |
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