THAL-SNS-032
- CAS No.
- 2139287-33-3
- Chemical Name:
- THAL-SNS-032
- Synonyms
- SNS-THAL-032;THAL-SNS-032;THAL-SNS-032, 10 mM in DMSO;THAL SNS 032,inhibit,PROTACs,CDK,THALSNS032,Cyclin dependent kinase,Inhibitor;N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide;1-Piperidineacetamide, 4-[[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]carbonyl]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]-
- CBNumber:
- CB64668606
- Molecular Formula:
- C40H52N8O10S2
- Molecular Weight:
- 869.02
- MDL Number:
- MFCD31689257
- MOL File:
- 2139287-33-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.40±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C, stored under nitrogen |
| solubility | DMSO : 100 mg/mL (115.07 mM; Need ultrasonic) |
| pka | 7.86±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | BXDZOYLPNAIDOC-UHFFFAOYSA-N |
| SMILES | N1(CC(NCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=O)CCC(C(NC2=NC=C(SCC3=NC=C(C(C)(C)C)O3)S2)=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
THAL-SNS-032 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2686 | THAL-SNS-032 ≥98% (HPLC) | 2139287-33-3 | 1MG | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2686 | THAL-SNS-032 ≥98% (HPLC) | 2139287-33-3 | 5MG | $463 | 2026-04-30 | Buy |
| Cayman Chemical | 40958 | THAL-SNS-032 ≥95% | 2139287-33-3 | 5mg | $384 | 2026-04-30 | Buy |
| Cayman Chemical | 40958 | THAL-SNS-032 ≥95% | 2139287-33-3 | 10mg | $614 | 2026-04-30 | Buy |
| Cayman Chemical | 40958 | THAL-SNS-032 ≥95% | 2139287-33-3 | 25mg | $864 | 2026-04-30 | Buy |
THAL-SNS-032 Chemical Properties, Uses, Production
Description
THAL-SNS-032 is a selective CDK9 degrader PROTAC composed of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).
Uses
THAL SNS 032 is a potent, selective and cereblon-dependent degrader of CDK9 (EC50 = 4 nM). Displays >15-fold selectivity for CDK9 over other CDKs (EC50 values are 62, 171 and 398 nM for CDK2, CDK1 and CDK7, respectively). Induces complete degradation of CDK9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines.
Biological Activity
THAL-SNS-032, a small molecule formed by conjugating the multi-targeting kinase inhibitor SNS-032 to thalidomide, induced potent and selective degradation of CDK9 in a CRBN-dependent fashion. Treatment with THAL-SNS-032 resulted in selective degradation of CDK9 with limited effects on the protein level of other CDKs. Furthermore, THAL-SNS-032 had a prolonged pharmacodynamic effect compared with traditional kinase inhibitors. The antitumoral activity of THAL-SNS-032 in cell lines expressing ER or both ER and HER2, including luminal A cells, has been demonstrated[1-2].
storage
Store at -20°C
References
[1] Calla M Olson. “Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.” Nature chemical biology 14 2 (2017): 163–170.
[2] María Del Mar Noblejas-López. “Antitumoral Activity of a CDK9 PROTAC Compound in HER2-Positive Breast Cancer.” International Journal of Molecular Sciences 23 10 (2022).
THAL-SNS-032 Preparation Products And Raw materials
Raw materials
Preparation Products
THAL-SNS-032 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Borl Biotechnology Co.,LTD | 13656121842 | luyan0021@163.com | China | 265 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
View Latest Price from THAL-SNS-032 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | THAL-SNS-032
2139287-33-3
|
1mg | 98%min | 500mg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-27 | THAL-SNS-032
2139287-33-3
|
$118.00-432.00 | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-06 | THAL-SNS-032
2139287-33-3
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- THAL-SNS-032
2139287-33-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- THAL-SNS-032
2139287-33-3
- $118.00-432.00
- 99.68%
- TargetMol Chemicals Inc.
-
- THAL-SNS-032
2139287-33-3
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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